- Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells
[作者:Okabe, J; Orlowski, C; Balcerczyk, A; Tikellis, C; Thomas, MC; Cooper, ME; El-Osta, A,期刊:Circulation Research, 页码:1067-U121 , 文章类型: Article,,卷期:2012年110-8]
- Rationale: Epigenetic changes are implicated in the persisting vascular effects of hyperglycemia. The precise mechanism whereby chromatin structure and subsequent gene expression are regulated by glucose in vascular endo...
- Revascularization of Ischemic Skeletal Muscle by Estrogen-Related Receptor-gamma
[作者:Matsakas, A; Yadav, V; Lorca, S; Evans, RM; Narkar, VA,期刊:Circulation Research, 页码:1087-1096 , 文章类型: Article,,卷期:2012年110-8]
- Rationale: Oxidative myofibers in the skeletal muscles express high levels of angiogenic factors, have dense vasculature, and promptly revascularize during ischemia. Estrogen-related receptor-gamma (ERR gamma) activates ...
- Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice
[作者:Doring, Y; Drechsler, M; Wantha, S; Kemmerich, K; Lievens, D; Vijayan, S; Gallo, RL; Weber, C; Soehnlein, O,期刊:Circulation Research, 页码:1052-U73 , 文章类型: Article,,卷期:2012年110-8]
- Rationale: Neutrophils have been reported to contribute to early atherosclerotic lesion formation. Mechanisms of neutrophil-driven atherosclerosis remain unclear so far. Objective: Investigation of the role of the neutro...
- Mitochondria and Cardiovascular Aging
[作者:Dai, DF; Rabinovitch, PS; Ungvari, Z,期刊:Circulation Research, 页码:1109-1124 , 文章类型: Review,,卷期:2012年110-8]
- Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in experimental animal models have indicated the central role of mitochondria both in lifespan determination and in cardiovascular agi...
- Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging Mechanisms and Therapeutic Opportunities
[作者:Dutta, D; Calvani, R; Bernabei, R; Leeuwenburgh, C; Marzetti, E,期刊:Circulation Research, 页码:1125-1138 , 文章类型: Review,,卷期:2012年110-8]
- The prevalence of cardiovascular disease increases with advancing age. Although long-term exposure to cardiovascular risk factors plays a major role in the etiopathogenesis of cardiovascular disease, intrinsic cardiac ag...
- Growth Factors, Nutrient Signaling, and Cardiovascular Aging
[作者:Fontana, L; Vinciguerra, M; Longo, VD,期刊:Circulation Research, 页码:1139-1151 , 文章类型: Review,,卷期:2012年110-8]
- Growth factors regulated by specific macronutrients have been shown to promote aging and accelerate mortality in the majority of the organisms studied. In particular, the enzymes activated by growth hormone, insulin, and...
- The Interferon Stimulated Gene 12 Inactivates Vasculoprotective Functions of NR4A Nuclear Receptors
[作者:Papac-Milicevic, N; Breuss, JM; Zaujec, J; Ryban, L; Plyushch, T; Wagner, GA; Fenzl, S; Dremsek, P; Cabaravdic, M; Steiner, M; Glass, CK; Binder, CJ; Uhrin, P; Binder, BR,期刊:Circulation Research, 页码:E50-U35 , 文章类型: Article,,卷期:2012年110-8]
- Rationale: Innate and adaptive immune responses alter numerous homeostatic processes that are controlled by nuclear hormone receptors. NR4A1 is a nuclear receptor that is induced in vascular pathologies, where it mediate...
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