- Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4
[作者：Pang, SS; Tang, HQ; Zhuo, S; Zang, YQ; Le, YY,期刊：Diabetes, 页码：3041-3048 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE Toll-like receptor 4 (TLR4) has been reported to induce insulin resistance through inflammation in high-fat-fed mice. However, the physiological role of TLR4 in metabolism is unknown. Here, we investigated the ...
- Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss Links With Metabolic and Low-Grade Inflammation Markers
[作者：Furet, JP; Kong, LC; Tap, J; Poitou, C; Basdevant, A; Bouillot, JL; Mariat, D; Corthier, G; Dore, J; Henegar, C; Rizkalla, S; Clement, K,期刊：Diabetes, 页码：3049-3057 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity re...
- Conditional Gene Targeting in Mouse Pancreatic beta-Cells Analysis of Ectopic Cre Transgene Expression in the Brain
[作者：Wicksteed, B; Brissova, M; Yan, WB; Opland, DM; Plank, JL; Reinert, RB; Dickson, LM; Tamarina, NA; Philipson, LH; Shostak, A; Bernal-Mizrachi, E; Elghazi, L; Roe, MW; Labosky, PA; Myers, MG; Gannon, M; Powers, AC; Dempsey, PJ,期刊：Diabetes, 页码：3090-3098 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE-Conditional gene targeting has been extensively used for in vivo analysis of gene function in beta-cell biology. The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate be...
- Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
[作者：Sloop, KW; Willard, FS; Brenner, MB; Ficorilli, J; Valasek, K; Showalter, AD; Farb, TB; Cao, JXC; Cox, AL; Michael, MD; Sanfeliciano, SMG; Tebbe, MJ; Coghlan, MJ,期刊：Diabetes, 页码：3099-3107 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE The clinical effectiveness of parenterally-administered glucagon-like peptide-1 (GLP-1) mimetics to improve glucose control in patients suffering from type 2 diabetes strongly supports discovery pursuits aimed ...
- In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic beta-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes
[作者：Gaddy, DF; Riedel, MJ; Pejawar-Gaddy, S; Kieffer, TJ; Robbins, PD,期刊：Diabetes, 页码：3108-3116 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE The purpose of the current study was to determine whether double-stranded adeno-associated virus (dsAAV)-mediated in vivo expression of beta-cell growth factors, glucagon-like peptide-1 (GLP-1) and the NK1 frag...
- Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance
[作者：Briancon, N; Mcnay, DE; Maratos-Flier, E; Flier, JS,期刊：Diabetes, 页码：3074-3084 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE The adipokine hormone leptin triggers signals in the brain that ultimately lead to decreased feeding and increased energy expenditure. However, obesity is most often associated with elevated plasma leptin level...
- Associations of Six Single Nucleotide Polymorphisms in Obesity-Related Genes With BMI and Risk of Obesity in Chinese Children
[作者：Wu, LJ; Xi, B; Zhang, MX; Shen, Y; Zhao, XY; Cheng, H; Hou, DQ; Sun, DD; Ott, J; Wang, XY; Mi, J,期刊：Diabetes, 页码：3085-3089 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE-Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and ob...
- Deletion of Pten in Pancreatic beta-Cells Protects Against Deficient beta-Cell Mass and Function in Mouse Models of Type 2 Diabetes
[作者：Wang, LY; Liu, YF; Lu, SY; Nguyen, KTT; Schroer, SA; Suzuki, A; Mak, TW; Gaisano, H; Woo, M,期刊：Diabetes, 页码：3117-3126 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE Type 2 diabetes is characterized by diminished pancreatic beta-cell mass and function. Insulin signaling within the beta-cells has been shown to play a critical role in maintaining the essential function of the...
- Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and Adolescents
[作者：Goran, MI; Walker, R; Le, KA; Mahurkar, S; Vikman, S; Davis, JN; Spruijt-Metz, D; Weigensberg, MJ; Allayee, H,期刊：Diabetes, 页码：3127-3130 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE A genome-wide study of adults identified a variant of PNPLA3 (rs738409) associated with similar to twofold higher liver fat. The purpose of this study was to examine the influence of PNPLA3 genotype on liver fa...
- Parathyroid Hormone-Related Protein Enhances Human beta-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression
[作者：Kondegowda, NG; Joshi-Gokhale, S; Harb, G; Williams, K; Zhang, XY; Takane, KK; Zhang, PL; Scott, DK; Stewart, AF; Garcia-Ocana, A; Vasavada, RC,期刊：Diabetes, 页码：3131-3138 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE Inducing human beta-cell growth while enhancing function is a major goal in the treatment of diabetes. Parathyroid hormone-related protein (PTHrP) enhances rodent beta-cell growth and function through the parat...
- Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes
[作者：Jurewicz, M; Yang, SM; Augello, A; Godwin, JG; Moore, RF; Azzi, J; Fiorina, P; Atkinson, M; Sayegh, MH; Abdi, R,期刊：Diabetes, 页码：3139-3147 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE A number of clinical trials are underway to test whether mesenchymal stem cells (MSCs) are effective in treating various diseases, including type 1 diabetes. Although this cell therapy holds great promise, the ...
- Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection
[作者：Fousteri, G; Chan, JR; Zheng, YN; Whiting, C; Dave, A; Bresson, D; Croft, M; von Herrath, M,期刊：Diabetes, 页码：3148-3158 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE Development of antigen-specific strategies to treat or prevent type 1 diabetes has been slow and difficult because of the lack of experimental tools and defined biomarkers that account for the underlying therap...
- High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function
[作者：Chronopoulos, A; Tang, A; Beglova, E; Trackman, PC; Roy, S,期刊：Diabetes, 页码：3159-3166 , 文章类型： Proceedings Paper，,卷期：2010年59-12]
- OBJECTIVE In diabetes, retinal vascular basement membrane (BM) undergoes significant thickening and compromises vessel function including increased vascular permeability, a prominent lesion of early diabetic retinopathy....
- Relationships of Circulating Sex Hormone-Binding Globulin With Metabolic Traits in Humans
[作者：Peter, A; Kantartzis, K; Machann, J; Schick, F; Staiger, H; Machicao, F; Schleicher, E; Fritsche, A; Haring, HU; Stefan, N,期刊：Diabetes, 页码：3167-3173 , 文章类型： Article，,卷期：2010年59-12]
- OBJECTIVE Recent data suggested that sex hormone-binding globulin (SHBG) levels decrease when fat accumulates in the liver and that circulating SHBG may be causally involved in the pathogenesis of type 2 diabetes in huma...
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