- Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
[作者：Yang, CS; Lam, CKL; Chari, M; Cheung, GWC; Kokorovic, A; Gao, S; Leclerc, I; Rutter, GA; Lam, TKT,期刊：Diabetes, 页码：2435-2443 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy homeostasis by sensing nutritional and hormonal signals. However, the role of hypothalamic AMPK in glucose production reg...
- Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study (vol 58, pg 1668, 2009)
[作者：Hovind, P; Rossing, P; Tarnow, L; Johnson, RJ; Parving, HH,期刊：Diabetes, 页码：2695-2695 , 文章类型： Correction，,卷期：2010年59-10]
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- Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
[作者：Ussher, JR; Koves, TR; Cadete, VJJ; Zhang, LY; Jaswal, JS; Swyrd, SJ; Lopaschuk, DG; Proctor, SD; Keung, W; Muoio, DM; Lopaschuk, GD,期刊：Diabetes, 页码：2453-2464 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE It has been proposed that skeletal muscle insulin resistance arises from the accumulation of intramyocellular lipid metabolites that impede insulin signaling, including diacylglycerol and ceramide. We determine...
- Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle
[作者：Lefort, N; Glancy, B; Bowen, B; Willis, WT; Bailowitz, Z; De Filippis, EA; Brophy, C; Meyer, C; Hojlund, K; Yi, ZP; Mandarino, LJ,期刊：Diabetes, 页码：2444-2452 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE The contribution of mitochondrial dysfunction to skeletal muscle insulin resistance remains elusive. Comparative proteomics are being applied to generate new hypotheses in human biology and were applied here to...
- Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids
[作者：McQuaid, SE; Humphreys, SM; Hodson, L; Fielding, BA; Karpe, F; Frayn, KN,期刊：Diabetes, 页码：2465-2473 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE-Gluteo-femoral, in contrast to abdominal, fat accumulation appears protective against diabetes and cardiovascular disease. Our objective was to test the hypothesis that this reflects differences in the ability ...
- Antiobesity Effect of Eicosapentaenoic Acid in High-Fat/High-Sucrose Diet Induced Obesity Importance of Hepatic Lipogenesis
[作者：Sato, A; Kawano, H; Notsu, T; Ohta, M; Nakakuki, M; Mizuguchi, K; Itoh, M; Suganami, T; Ogawa, Y,期刊：Diabetes, 页码：2495-2504 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE Given the pleiotropic effect of eicosapentaenoic acid (EPA), it is interesting to know whether EPA is capable of improving obesity. Here we examined the anti-obesity effect of EPA in mice with two distinct mode...
- Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
[作者：Chun, TH; Inoue, M; Morisaki, H; Yamanaka, I; Miyamoto, Y; Okamura, T; Sato-Kusubata, K; Weiss, SJ,期刊：Diabetes, 页码：2484-2494 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE In white adipose tissue, adipocytes and adipocyte precursor cells are enmeshed in a dense network of type I collagen fibrils. The fate of this pericellular collagenous web in diet-induced obesity, however, is u...
- Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
[作者：Zaragosi, LE; Wdziekonski, B; Villageois, P; Keophiphath, M; Maumus, M; Tchkonia, T; Bourlier, V; Mohsen-Kanson, T; Ladoux, A; Elabd, C; Scheideler, M; Trajanoski, Z; Takashima, Y; Amri, EZ; Lacasa, D; Sengenes, C; Ailhaud, G; Clement, K; Bouloumie, A; Kirkland, JL; Dani, C,期刊：Diabetes, 页码：2513-2521 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE Growth of white adipose tissue takes place in normal development and in obesity. A pool of adipose progenitors is responsible for the formation of new adipocytes and for the potential of this tissue to expand i...
- Antiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats
[作者：Xiong, Y; Shen, L; Liu, KJ; Tso, P; Xiong, YQ; Wang, GJ; Woods, SC; Liu, M,期刊：Diabetes, 页码：2505-2512 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE Obesity and type 2 diabetes are national and worldwide epidemics. Because currently available antiobesity and antidiabetic drugs have limited efficacy and/or safety concerns, identifying new medicinal agents, s...
- MafA and MafB Regulate Genes Critical to beta-Cells in a Unique Temporal Manner
[作者：Artner, I; Hang, Y; Mazur, M; Yamamoto, T; Guo, M; Lindner, J; Magnuson, MA; Stein, R,期刊：Diabetes, 页码：2530-2539 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE-Several transcription factors are essential to pancreatic islet beta-cell development, proliferation, and activity, including MafA and MafB. However, MafA and MafB are distinct from others in regard to temporal...
- G alpha o Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic beta-Cells
[作者：Zhao, AZ; Ohara-Imaizumi, M; Brissova, M; Benninger, RKP; Xu, YW; Hao, YH; Abramowitz, J; Boulay, G; Powers, AC; Piston, D; Jiang, MS; Nagamatsu, S; Birnbaumer, L; Gu, GQ,期刊：Diabetes, 页码：2522-2529 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE Pertussis toxin uncoupling-based studies have shown that Gal and G alpha o can inhibit insulin secretion in pancreatic beta-cells. Yet it is unclear whether G alpha i and G alpha o operate through identical mec...
- Roles of Bcl-3 in the Pathogenesis of Murine Type 1 Diabetes
[作者：Ruan, QG; Zheng, SJ; Palmer, S; Carmody, RJ; Chen, YH,期刊：Diabetes, 页码：2549-2557 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE-It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood. Bcl-3 (B-cell lymphoma 3) is an atypical member of the I ka...
- Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice
[作者：Bindom, SM; Hans, CP; Xia, HJ; Boulares, H; Lazartigues, E,期刊：Diabetes, 页码：2540-2548 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE-Several clinical studies have shown the benefits of renin-artgiotensin system (RAS) blockade in the development of diabetes, and a local RAS has been identified in pancreatic islets. Angiotensin I-converting en...
- Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle Establishment of a Vascular System Similar to That in Native Islets
[作者：Christoffersson, G; Henriksnas, J; Johansson, L; Rolny, C; Ahlstrom, H; Caballero-Corbalan, J; Segersvard, R; Permert, J; Korsgren, O; Carlsson, PO; Phillipson, M,期刊：Diabetes, 页码：2569-2578 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE-Curing type 1 diabetes by transplanting pancreatic islets into the liver is associated with poor long-term outcome and graft failure at least partly due to inadequate graft revascularization. The aim of the cur...
- Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates
[作者：Berman, DM; Willman, MA; Han, DM; Kleiner, G; Kenyon, NM; Cabrera, O; Karl, JA; Wiseman, RW; O'Connor, DH; Bartholomew, AM; Kenyon, NS,期刊：Diabetes, 页码：2558-2568 , 文章类型： Article，,卷期：2010年59-10]
- OBJECTIVE-To test the graft-promoting effects of mesenchymal stem cells (MSCs) in a cynomolgus monkey model of islet/bone marrow transplantation. RESEARCH DESIGN AND METHODS-Cynomolgus MSCs were obtained from iliac crest...
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