- Significance of alpha-crystallin heteropolymer with a 3 : 1 alpha A/alpha B ratio: chaperone-like activity, structure and hydrophobicity
[作者:Srinivas, PNBS; Reddy, PY; Reddy, GH,期刊:Biochemical Journal, 页码:453-460 , 文章类型: Article,,卷期:2008年414-3]
- The small heat-shock protein alpha-crystallin isolated from the eye lens exists as a large (700 kDa) heteropolymer composed of two subunits, alpha A and alpha B, of 20 kDa each. Although trace amounts of alpha A-crystall...
- The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network
[作者:Spooner, RA; Watson, P; Smith, DC; Boal, F; Amessou, M; Johannes, L; Clarkson, GJ; Lord, JM; Stephens, DJ; Roberts, LM,期刊:Biochemical Journal, 页码:471-484 , 文章类型: Article,,卷期:2008年414-3]
- The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1] benzothieno[2,3-d]pyrimidin-4-yl)hydrazone benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi-E...
- Localization and characterization of the novel protein encoded by C20orf3
[作者:Ilhan, A; Gartner, W; Nabokikh, A; Daneva, T; Majdic, O; Cohen, G; Bohmig, GA; Base, W; Horl, WH; Wagner, L,期刊:Biochemical Journal, 页码:485-495 , 文章类型: Article,,卷期:2008年414-3]
- In the present study, we characterized the gene product of open reading frame 3 encoded at human chromosome 20 (C20orf3), which represents it member of the lactonohydrolase Super family. Multiple-tissue Northern blot ana...
- Interaction of tryptophan derivatives with SLC6A14 (ATB(0,+)) reveals the potential of the transporter as a drug target for cancer chemotherapy
[作者:Karunakaran, S; Umapathy, NS; Thangaraju, M; Hatanaka, T; Itagaki, S; Munn, DH; Prasad, PD; Ganapathy, V,期刊:Biochemical Journal, 页码:343-355 , 文章类型: Article,,卷期:2008年414-3]
- ATB(0,+) [SLC6A14 (Solute carrier family 6 member 14)] is an Na+/Cl--coupled amino acid transporter whose expression is up-regulated in cancer. 1-Methyltryptophan is an inducer of immune surveillance against tumour Cells...
- Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket
[作者:Frazzetto, M; Suphioglu, C; Zhu, J; Schmidt-Kittler, O; Jennings, IG; Cranmer, SL; Jackson, SP; Kinzler, KW; Vogelstein, B; Thompson, PE,期刊:Biochemical Journal, 页码:383-390 , 文章类型: Article,,卷期:2008年414-3]
- The last few years have seen the identification of numerous small molecules that selectively inhibit specific class I isoforms of PI3K (phosphoinositide 3-kinase), yet little has been revealed about the molecular basis f...
- In vivo modular control analysis of energy metabolism in contracting skeletal muscle
[作者:Arsac, LM; Beuste, C; Miraux, S; Deschodt-Arsac, V; Thiaudiere, E; Franconi, JM; Diolez, PH,期刊:Biochemical Journal, 页码:391-397 , 文章类型: Article,,卷期:2008年414-3]
- We used P-31 MRS (magnetic resonance spectroscopy) measurements of energetic intermediates [ATP, P-i and PCr (phosphocreatine)] in combination with the analytical tools of metabolic control analysis to study in vivo ener...
- Characterization of the topology and functional domains of RKTG
[作者:Luo, X; Feng, L; Jiang, X; Xiao, F; Wang, Z; Feng, GS; Chen, Y,期刊:Biochemical Journal, 页码:399-406 , 文章类型: Article,,卷期:2008年414-3]
- RKTG (Raf kinase trapping to Golgi) is exclusively localized at the Golgi apparatus and functions as a spatial regulator of Raf-1 kinase by sequestrating Raf-1 to the Golgi. Based on the structural similarity with adipon...
- Ins(1,4,5)P-3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism
[作者:Windhorst, S; Blechner, C; Lin, HY; Elling, C; Nalaskowski, M; Kirchiberger, T; Guise, AH; Mayr, GW,期刊:Biochemical Journal, 页码:407-417 , 文章类型: Article,,卷期:2008年414-3]
- In the present study, effects of increased IP3K-A [Ins(l,4,5)P-3 3-kinase-A] expression were analysed. H1299 cells overexpressing IP3K-A formed branching protrusions, and under three-dimensional culture conditions, they ...
- Two zinc finger transcription factors, CrzA and SltA, are involved in cation homoeostasis and detoxification in Aspergillus nidulans
[作者:Spielvogel, A; Findon, H; Arst, HN; Araujo-Bazan, L; Hernandez-Ortiz, P; Stahl, U; Meyer, V; Espeso, EA,期刊:Biochemical Journal, 页码:419-429 , 文章类型: Article,,卷期:2008年414-3]
- To investigate cation adaptation and homoeostasis in Aspergillus nidulans, two transcription-factor-encoding genes have been characterized. The A. nidulans orthologue crzA of the Saccharomyces cerevisiae CRZI gene, encod...
- Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor
[作者:Kong, H; Jones, PP; Koop, A; Zhang, L; Duff, HJ; Chen, SRW,期刊:Biochemical Journal, 页码:441-452 , 文章类型: Article,,卷期:2008年414-3]
- Caffeine has long been Used as a pharmacological probe for studying RyR (ryanodine receptor)-mediated Ca2+ release and cardiac arrhythmias. However, the precise mechanism by which caffeine activates RyRs is elusive. In t...
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