个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共45条记录   Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation. [作者：Suksamrarn, Apichart;Ponglikitmongkol, Mathurose;Wongkrajang, Kanjana;Chindaduang, Anon;Kittidanairak, Suthadta;Jankam, Aroon;Yingyongnarongkul, Boon-ek;Kittipanumat, Narin;Chokchaisiri, Ratchanaporn;Khetkam, Pichit;Piyachaturawat, Pawinee;,期刊：Bioorganic & Medicinal Chemistry, 页码：6891-6902 , 文章类型： 研究论文，,卷期：2008年16-14] Three new and nine known diarylheptanoids were isolated from the rhizomes of Curcuma comosa Roxb. The abs. stereochem. of the isolated compds. has also been detd. using the modified Mosher's method. The isolated compds... Synthesis and cytotoxic activities of usnic acid derivatives. [作者：Bazin, Marc-Antoine;Lamer, Anne-Cecile Le;Delcros, Jean-Guy;Rouaud, Isabelle;Uriac, Philippe;Boustie, Joel;Corbel, Jean-Charles;Tomasi, Sophie;,期刊：Bioorganic & Medicinal Chemistry, 页码：6860-6866 , 文章类型： 研究论文，,卷期：2008年16-14] Nine usnic acid-amine conjugates were evaluated on murine and human cancer cell lines. The polyamine derivs. showed significant cytotoxicity in L1210 cells. Their activities appeared to be independent of the polyamine ... Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation. [作者：Lev-Goldman, Vered;Mester, Brenda;Ben-Aroya, Nurit;Hanoch, Tamar;Rupp, Barbara;Stanoeva, Tsvetanka;Gescheidt, Georg;Seger, Rony;Koch, Yitzhak;Weiner, Lev;Fridkin, Mati;,期刊：Bioorganic & Medicinal Chemistry, 页码：6789-6798 , 文章类型： 研究论文，,卷期：2008年16-14] The authors synthesized two carminic acid (7-a-D-glucopyranosyl-9,10-dihydro-3,5,6,8-tetrahydroxy-1-methyl-9,10- dioxo-2-anthracene carboxlic acid, CA)-GnRH conjugates to be used as a model for potential photoactive targ... Acridone-tagged DNA as a new probe for DNA detection by fluorescence resonance energy transfer and for mismatch DNA recognition. [作者：Hagiwara, Yasuhisa;Hasegawa, Tomoya;Shoji, Atushi;Kuwahara, Masayasu;Ozaki, Hiroaki;Sawai, Hiroaki;,期刊：Bioorganic & Medicinal Chemistry, 页码：7013-7020 , 文章类型： 研究论文，,卷期：2008年16-14] Acridone is highly fluorescent and stable against photodegrdn., oxidn., and heat. It is also a small mol. with no charge, making it a promising fluorescent agent for use in a DNA probe. Thus, we have prepd. 5'-terminal... BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. [作者：Hwang, Eun Mi;Ryu, Young Bae;Kim, Hoi Young;Kim, Dong-Gyu;Hong, Seong-Geun;Lee, Jin Hwan;Curtis-Long, Marcus J.;Jeong, Seong Hun;Park, Jae-Yong;Park, Ki Hun;,期刊：Bioorganic & Medicinal Chemistry, 页码：6669-6674 , 文章类型： 研究论文，,卷期：2008年16-14] In order to access b-secretase (BACE1), and enzyme strongly implicated in the cause of Alzheimer's disease, inhibitors must possess sufficient lipophilicity to traverse two lipid bilayers. Current drug candidates, which... Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides. [作者：Gerland, Beatrice;Desire, Jerome;Balzarini, Jan;Decout, Jean-Luc;,期刊：Bioorganic & Medicinal Chemistry, 页码：6824-6831 , 文章类型： 研究论文，,卷期：2008年16-14] Herein, we report the synthesis, antiviral and cytostatic effects of nucleosides bearing a 3'-disulfide function as prodrugs of potentially active 3'-mercaptonucleotides. The lack of the anti-HIV effects in mutant CEM/T... G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution. [作者：Okamoto, Kenji;Sannohe, Yuta;Mashimo, Tomoko;Sugiyama, Hiroshi;Terazima, Masahide;,期刊：Bioorganic & Medicinal Chemistry, 页码：6873-6879 , 文章类型： 研究论文，,卷期：2008年16-14] The human telomere is known to form the G-quadruplex structure to inhibit the activity of telomerase. Its detailed structure has been of great interest. Recently, two kinds of the parallel-antiparallel hybrid structure... Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide. [作者：Inami, Keiko;Mochizuki, Masataka;,期刊：Bioorganic & Medicinal Chemistry, 页码：7070-7077 , 文章类型： 研究论文，,卷期：2008年16-14] Oxidn. of 2-acetylaminofluorene (AAF), a carcinogen, by a chem. model for cytochrome P 450 was investigated to identify an active mutagen and elucidate the oxidn. pathway. The oxidn. system consisted of a water-insol. t... Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2. [作者：Andersson, Hanna;Demaegdt, Heidi;Vauquelin, Georges;Lindeberg, Gunnar;Karlen, Anders;Hallberg, Mathias;,期刊：Bioorganic & Medicinal Chemistry, 页码：6924-6935 , 文章类型： 研究论文，,卷期：2008年16-14] Analogs of the hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2 and a phenylacetic or benzoic acid moiety replacing His4-Pro5-Phe6 have be... Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. [作者：Huang, Hsu-Shan;Huang, Kuo-Feng;Li, Cho-Lu;Huang, Yi-Yuan;Chiang, Yi-Hsuan;Huang, Fong-Chun;Lin, Jing-Jer;,期刊：Bioorganic & Medicinal Chemistry, 页码：6976-6986 , 文章类型： 研究论文，,卷期：2008年16-14] Telomerase is important in tumor initiation and cellular immortalization. Given the striking correlations between telomerase activity and proliferation capacity in tumor cells, telomerase had been considered as a potenti... Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI). [作者：Martinez, Alberto;Moreno, Virtudes;Sanglas, Laura;de Llorens, Rafael;Aviles, Francesc X.;Lorenzo, Julia;,期刊：Bioorganic & Medicinal Chemistry, 页码：6832-6840 , 文章类型： 研究论文，,卷期：2008年16-14] The interaction of the well-known antitumor drug cisplatin cis-[PtCl2(NH3)2] and the compd. trans-[PtCl2NH3(4-hydroxymethylpyridine)] with the small protein potato carboxypeptidase inhibitor (PCI) and a PCI mutant in whi... Synthesis, biological evaluation and molecular modeling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. [作者：Jones, Matthew A.;Morton, James D.;Coxon, James M.;McNabb, Stephen B.;Lee, Hannah Y.-Y.;Aitken, Steven G.;Mehrtens, Janna M.;Robertson, Lucinda J. G.;Neffe, Axel T.;Miyamoto, Shigeru;Bickerstaffe, Roy;Gately, Karl;Wood, Jacqueline M.;Abell, Andrew D.;,期刊：Bioorganic & Medicinal Chemistry, 页码：6911-6923 , 文章类型： 研究论文，,卷期：2008年16-14] Ten N-heterocyclic dipeptide aldehydes (4-13) have been synthesized and evaluated as inhibitors of ovine calpain 1 (o-CAPN1) and ovine calpain 2 (o-CAPN2). N-(5-formylpyrrole-2-carbonyl)-L-valylleucinal (9; was the most... Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme. [作者：Zhang, Meihui;Nguyen, Jeffrey-Tri;Kumada, Henri-Obadja;Kimura, Tooru;Cheng, Maosheng;Hayashi, Yoshio;Kiso, Yoshiaki;,期刊：Bioorganic & Medicinal Chemistry, 页码：6880-6890 , 文章类型： 研究论文，,卷期：2008年16-14] Adult T-cell leukemia and tropical spastic paraparesis/HTLV-I-assocd. myelopathy are only some of the more common end results of an infection with a human T-cell leukemia virus type 1 (HTLV-I). Expanding from their prev... N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase. [作者：Goeminne, Annelies;Berg, Maya;McNaughton, Michael;Bal, Gunther;Surpateanu, Georgiana;Van der Veken, Pieter;De Prol, Stijn;Versees, Wim;Steyaert, Jan;Haemers, Achiel;Augustyns, Koen;,期刊：Bioorganic & Medicinal Chemistry, 页码：6752-6763 , 文章类型： 研究论文，,卷期：2008年16-14] A key enzyme within the purine salvage pathway of parasites, nucleoside hydrolase, is proposed as a good target for new antiparasitic drugs. N-arylmethyl-iminoribitol derivs. as a novel class of inhibitors against a pur... 2-Substituted-16-ene-22-thia-1a,25-dihydroxy-26,27-dimethyl-19-norvit amin D3 analogs: Synthesis, biological evaluation, and crystal structure. [作者：Shimizu, Masato;Miyamoto, Yukiko;Takaku, Hajime;Matsuo, Mayumi;Nakabayashi, Makoto;Masuno, Hiroyuki;Udagawa, Nobuyuki;DeLuca, Hector F.;Ikura, Teikichi;Ito, Nobutoshi;,期刊：Bioorganic & Medicinal Chemistry, 页码：6949-6964 , 文章类型： 研究论文，,卷期：2008年16-14] Recently, we have found that 16-ene-22-thia-26,27-dimethyl-19-norvitamin D3 analogs are 20 times more active than the natural hormone 1a,25-dihydroxyvitamin D3 in terms of transcriptional activity. To further investigat... QSAR modeling of the antifungal activity against Candida albicans for a diverse set of organic compounds. [作者：Katritzky, Alan R.;Slavov, Svetoslav H.;Dobchev, Dimitar A.;Karelson, Mati;,期刊：Bioorganic & Medicinal Chemistry, 页码：7055-7069 , 文章类型： 研究论文，,卷期：2008年16-14] The mol. structures of 83 diverse org. compds. are correlated by a quant. structure-activity relationship (QSAR) to their min. inhibitor concns. (MIC expressed as log(1/MIC)), involving 6 descriptors with R2 = 0.788, F =...