- Metalloproteases as potential therapeutic targets in arthritis treatment
[作者:Rowan, AD; Litherland, GJ; Hui, W; Milner, JM,期刊:Expert Opinion on Therapeutic Targets, 页码:1-18 , 文章类型: Review,,卷期:2008年12-1]
- Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for therapeutic intervention for some time, although clinical efficacy ...
- Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration
[作者:Westerlund, N; Zdrojewska, J; Courtney, MJ; Coffey, ET,期刊:Expert Opinion on Therapeutic Targets, 页码:31-43 , 文章类型: Review,,卷期:2008年12-1]
- Background: Cell stress and tissue injury lead to c-Jun N-terminal kinase (JNK) activation, which is known to contribute to cell death. Paradoxically, strong evidence supports an important role for JNK in the regeneratio...
- Targeting synuclein-gamma to counteract drug resistance in cancer
[作者:Singh, VK; Jia, Z,期刊:Expert Opinion on Therapeutic Targets, 页码:59-68 , 文章类型: Review,,卷期:2008年12-1]
- Background: Expression of synuclein-gamma (SNCG) protein is elevated in the advanced stages of many types of cancers, including ovarian, lung, liver, esophagus, colon, prostate and, in particular, breast. In breast carci...
- Topiramate and Type 2 diabetes: an old wine in a new bottle
[作者:Khanna, V; Arumugam, S; Roy, S; Mittra, S; Bansal, VS,期刊:Expert Opinion on Therapeutic Targets, 页码:81-90 , 文章类型: Review,,卷期:2008年12-1]
- and allied neurological problems since 1999. Recently, a series of newer findings for the use of topiramate have cropped up, which include Type 2 diabetes and obesity. in a series of clinical studies, a subset of neurolo...
- Applying small RNA molecules to the directed treatment of human diseases: realizing the potential
[作者:Pappas, TC; Bader, AG; Andruss, BF; Brown, D; Ford, LP,期刊:Expert Opinion on Therapeutic Targets, 页码:115-127 , 文章类型: Review,,卷期:2008年12-1]
- Small interfering RNAs (siRNA) and microRNAs (miRNA) are gaining considerable attention in the pharmaceutical and biotechnology industries, as research has revealed their likely clinical and agricultural applications. Th...
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