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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共26条记录   Effect of Thioredoxin Deletion and p53 Cysteine Replacement on Human p53 Activity in Wild-Type and Thioredoxin Reductase Null Yeast [作者：Stoner, CS; Pearson, GD; Koc, A; Merwin, JR; Lopez, NI; Merrill, GF,期刊：Biochemistry, 页码：9156-9169 , 文章类型： Article，,卷期：2009年48-38] Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gen... Evaluation of Copper(2+) Affinities for the Prion Protein [作者：Nadal, RC; Davies, P; Brown, DR; Viles, JH,期刊：Biochemistry, 页码：8929-8931 , 文章类型： Article，,卷期：2009年48-38] The prion protein (PrP) is a cell-surface Cu2+ binding glcoprotein which call bind six copper ions. The role of Cu2+ in PrP function, misfolding, and prion disease has generated much interest; however, the field has been... Crystallographic and Catalytic Studies of the Peroxide-Shunt Reaction in a Diiron Hydroxylase [作者：Bailey, LJ; Fox, BG,期刊：Biochemistry, 页码：8932-8939 , 文章类型： Article，,卷期：2009年48-38] A diiron hydroxylase reaction typically begins by combination of O-2 with a diferrous center to form reactive intermediates capable of hydrocarbon hydroxylation. In this natural cycle, reducing equivalents are provided b... Metal Ion Interactions in the DNA Cleavage/Ligation Active Site of Human Topoisomerase II alpha [作者：Deweese, JE; Guengerich, FP; Burgin, AB; Osheroff, N,期刊：Biochemistry, 页码：8940-8947 , 文章类型： Article，,卷期：2009年48-38] Human topoisomerase II alpha utilizes a two-metal-ion mechanism for DNA cleavage. One of the metal ions (M-1(2+)) is believed to make a critical interaction with the 3'-bridging atom of the scissile phosphate, while the ... Exploring Damage Recognition Models in Prokaryotic Nucleotide Excision Repair with a Benzo[a]pyrene-Derived Lesion in UvrB [作者：Jia, L; Kropachev, K; Ding, SA; Van Houten, B; Geacintov, NE; Broyde, S,期刊：Biochemistry, 页码：8948-8957 , 文章类型： Article，,卷期：2009年48-38] The UvrB protein is a central unit for damage recognition in the prokaryotic nucleotide excision repair system, which excises bulky DNA lesions. We have utilized molecular modeling and MD simulations based on crystal str... A Paradigm Shift for the Amino Acid Editing Mechanism of Human Cytoplasmic Leucyl-tRNA Synthetase [作者：Pang, YLJ; Martinis, SA,期刊：Biochemistry, 页码：8958-8964 , 文章类型： Article，,卷期：2009年48-38] Leucyl-tRNA synthetase (LeuRS) has been identified as a target for a novel class of boron-containing small molecules that bind to its editing active site. When the 3' end of tRNA(Leu) binds to the editing active site, th... Multiple Protonation States of Vesicular Acetylcholine Transporter Detected by Binding of [H-3]Vesamicol [作者：Khare, P; White, AR; Parsons, SM,期刊：Biochemistry, 页码：8965-8975 , 文章类型： Article，,卷期：2009年48-38] Vesicular acetylcholine transporter (VAChT) is inhibited by (-)-vesamicol [(-)-trans-2-(4-phenylpiperidino)cyclohexanol], which binds tightly to an allosteric site. The tertiary alkylamine center in (-)-vesamicol is prot... Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A(2) and a beta-Sultam Inhibitor [作者：Luo, CY; Roussel, P; Dreier, J; Page, MGP; Paetzel, M,期刊：Biochemistry, 页码：8976-8984 , 文章类型： Article，,卷期：2009年48-38] Bacterial type I signal peptidase (SPase I), an essential membrane-bound endopeptidase with a unique Ser/Lys dyad mechanism, is being investigated as a potential novel antibiotic target. We present here binding and inhib... The Role of Arginine-127 at the Proximal NO-Binding Site in Determining the Electronic Structure and Function of 5-Coordinate NO-Heme in Cytochrome c ' of Rhodobacter sphaeroides [作者：Lee, B; Usov, OM; Grigoryants, VM; Myers, WK; Shapleigh, JP; Scholes, CP,期刊：Biochemistry, 页码：8985-8993 , 文章类型： Article，,卷期：2009年48-38] Cytochrome c' is a heme protein from a denitrifying variant of Rhodobacter sphaeroides which may serve to store and transport metabolic NO while protecting against NO toxicity. Its heme site bears resemblance through its... Structural Coupling of a Tyrosine Side Chain with the Non-Heme Iron Center in Photosystem II As Revealed by Light-Induced Fourier Transform Infrared Difference Spectroscopy [作者：Takahashi, R; Boussac, A; Sugiura, M; Noguchi, T,期刊：Biochemistry, 页码：8994-9001 , 文章类型： Article，,卷期：2009年48-38] The non-heme iron is located between the quinone electron acceptors, Q(A) and Q(B), in photosystem II (PSII), and together with its bicarbonate ligand, it regulates the electron and proton transfer reactions of quinone a... Prevention of Clostridium sordellii Lethal Toxin-Induced Apoptotic Cell Death by Tauroursodeoxycholic Acid [作者：Schulz, F; Just, I; Genth, H,期刊：Biochemistry, 页码：9002-9010 , 文章类型： Article，,卷期：2009年48-38] Virulent strains of Clostridium sordellii cause gangrenous myonecrosis in humans. The released lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are regarded as the major virulence factors. TcsL inactivates low molecular ... Amyloid-beta(1-42) Fibrillar Precursors Are Optimal for Inducing Tumor Necrosis Factor-alpha Production in the THP-1 Human Monocytic Cell Line [作者：Ajit, D; Udan, MLD; Paranjape, G; Nichols, MR,期刊：Biochemistry, 页码：9011-9021 , 文章类型： Article，,卷期：2009年48-38] Pathological studies have determined that fibrillar forms of amyloid-beta protein (A beta) comprise the characteristic neuritic plaques in Alzheimer's disease (AD). These Studies have also revealed significant inflammato... Urea-Induced Unfolding of Na,K-ATPase As Evaluated by Electron Paramagnetic Resonance Spectroscopy [作者：Babavali, M; Esmann, M; Fedosova, NU; Marsh, D,期刊：Biochemistry, 页码：9022-9030 , 文章类型： Article，,卷期：2009年48-38] Urea-induced unfolding of Na,K-ATPase from pig kidney and from shark salt gland was studied by electron paramagnetic resonance (EPR) spectroscopy of a nitroxyl derivative of maleimide covalently attached to sulfhydryl gr... Monitoring the Iron Status of the Ferroxidase Center of Escherichia coli Bacterioferritin Using Fluorescence Spectroscopy [作者：Lawson, TL; Crow, A; Lewin, A; Yasmin, S; Moore, GR; Le Brun, NE,期刊：Biochemistry, 页码：9031-9039 , 文章类型： Article，,卷期：2009年48-38] Ferritins solubilize and detoxify the essential metal iron through formation of a ferric mineral within the protein's central cavity, Key to this activity is an intrasubunit catalytic dinuclear iron center called the fer... Interpretation of p-Cyanophenylalanine Fluorescence in Proteins in Terms of Solvent Exposure and Contribution of Side-Chain Quenchers: A Combined Fluorescence, IR and Molecular Dynamics Study [作者：Taskent-Sezgin, H; Chung, J; Patsalo, V; Miyake-Stoner, SJ; Miller, AM; Brewer, SH; Mehl, RA; Green, DF; Raleigh, DP; Carrico, I,期刊：Biochemistry, 页码：9040-9046 , 文章类型： Article，,卷期：2009年48-38] The use of noncoded amino acids as spectroscopic probes of protein folding and function is growing rapidly, in large part because of advances in the methodology for their incorporation. Recently p-cyanophenylalanine has ... De Novo Molecular Modeling and Biophysical Characterization of Manduca sexta Eclosion Hormone [作者：Hull, JJ; Copley, KS; Schegg, KM; Quilici, DR; Schooley, DA; Welch, WH,期刊：Biochemistry, 页码：9047-9060 , 文章类型： Article，,卷期：2009年48-38] Eclosion hormone (EH) is all integral component in the cascade regulating the behaviors culminating in emergence of an insect from its old exoskeleton. Little is known regarding the EH solution Structure; consequently, w...