- Hydrogen Peroxide-Induced VCAM-1 Expression in Pancreatic Islets and beta-Cells Through Extracellular Ca2+ Influx
[作者:Lee, S; Ha, IS; Kim, JH; Park, KS; Han, KH; Kim, SH; Chae, YC; Kim, SH; Kim, YH; Suh, PG; Ryu, SH; Kim, JE; Bang, K; Hwang, JI; Yang, J; Park, KW; Chung, J; Ahn, C,期刊:Transplantation, 页码:1257-1266 , 文章类型: Article,,卷期:2008年86-9]
- Background. The use of porcine islets as alternatives to transplantable human islets is hampered by xenotransplant rejection. To identify molecular mechanisms that would allow subversion of xenoislet rejection, we invest...
- Depletion of Cells of Monocyte Lineage Prevents Loss of Renal Microvasculature in Murine Kidney Transplantation
[作者:Qi, F; Adair, A; Ferenbach, D; Vass, DG; Mylonas, KJ; Kipari, T; Clay, M; Kluth, DC; Hughes, J; Marson, LP,期刊:Transplantation, 页码:1267-1274 , 文章类型: Article,,卷期:2008年86-9]
- Background. Acute rejection increases the risk of late renal allograft loss with tubular atrophy, interstitial fibrosis, and microvascular rarefaction. Evidence supports a role for macrophages in promoting allograft inju...
- Induction of Donor-Specific T-Cell Hyporesponsiveness Using Dexamethasone-Treated Dendritic Cells in Two Fully Mismatched Rat Kidney Transplantation Models
[作者:Stax, AM; Gelderman, KA; Schlagwein, N; Essers, MC; Kamerling, SWA; Woltman, AM; van Kooten, C,期刊:Transplantation, 页码:1275-1282 , 文章类型: Article,,卷期:2008年86-9]
- Background: Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC ...
- Susceptibility of Human Mesenchymal Stem Cells to Tacrolimus, Mycophenolic Acid, and Rapamycin
[作者:Hoogduijn, MJ; Crop, MJ; Korevaar, SS; Peeters, AMA; Eijken, M; Maat, LPWM; Balk, AHMM; Weimar, W; Baan, CC,期刊:Transplantation, 页码:1283-1291 , 文章类型: Article,,卷期:2008年86-9]
- Background. Mesenchymal stem cells (MSC) have multilineage differentiation and immunomodulatory capacities and are potentially useful for therapeutic applications, such as tissue regeneration and control of alloreactivit...
- Multifunctional Magnetic Nanocarriers for Image-Tagged SiRNA Delivery to Intact Pancreatic Islets
[作者:Medarova, Z; Kumar, M; Ng, SW; Yang, JZ; Barteneva, N; Evgenov, NV; Petkova, V; Moore, A,期刊:Transplantation, 页码:1170-1177 , 文章类型: Article,,卷期:2008年86-9]
- Background. With the ultimate hope of finding a cure for diabetes, researches are looking into altering the genetic profile of the beta cell as a way to manage metabolic dysregulation. One of the most powerful new approa...
- Differentiation of Mouse Hepatic Progenitor Cells Induced by Hepatocyte Nuclear Factor-4 and Cell Transplantation in Mice With Liver Fibrosis
[作者:Suetsugu, A; Nagaki, M; Aoki, H; Motohashi, T; Kunisada, T; Moriwaki, H,期刊:Transplantation, 页码:1178-1186 , 文章类型: Article,,卷期:2008年86-9]
- Background. Hepatocyte nuclear factor-4 (HNF-4) plays a central role in the differentiation process of hepatic cells. We investigated the effects of an overexpression of HNF-4 on hepatic progenitor cells isolated from a ...
- Comparison of Sirolimus Plus Tacrolimus Versus Sirolimus Plus Cyclosporine in High-Risk Renal Allograft Recipients: Results From an Open-Label, Randomized Trial
[作者:Gaber, AO; Kahan, BD; Van Buren, C; Schulman, SL; Scarola, J; Neylan, JF,期刊:Transplantation, 页码:1187-1195 , 文章类型: Article,,卷期:2008年86-9]
- Background. The efficacy and safety of sirolimus (SRL) plus tacrolimus (TAC) versus SRL plus cyclosporine (CsA) were compared in high-risk renal allograft recipients.Methods. Evaluable patients (448) were randomly assign...
- Recovery of Graft Function in Pediatric Kidney Transplantation Is Not Affected by Delayed Introduction of Cyclosporine
[作者:Cransberg, K; Bouts, AH; Cornelissen, EAM; Lilien, MR; Van Hoeck, KJ; Hop, WCJ; Nauta, J,期刊:Transplantation, 页码:1199-1205 , 文章类型: Article,,卷期:2008年86-9]
- Background. Delayed graft function and acute rejections adversely affect the long-term survival of kidney transplantation. To decrease the incidences of these phenomena, we changed the initial immunosuppressive protocol ...
- Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients
[作者:Bandur, S; Petrasek, J; Hribova, P; Novotna, E; Brabcova, I; Viklicky, O,期刊:Transplantation, 页码:1206-1213 , 文章类型: Article,,卷期:2008年86-9]
- Background. Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes. Polymorphisms in these genes have been suggested t...
- Successful Treatment of Chronic Antibody-Mediated Rejection With IVIG and Rituximab in Pediatric Renal Transplant Recipients
[作者:Billing, H; Rieger, S; Ovens, J; Susal, C; Melk, A; Waldherr, R; Opelz, G; Tonshoff, B,期刊:Transplantation, 页码:1214-1221 , 文章类型: Article,,卷期:2008年86-9]
- Background. Chronic antibody-mediated rejection (CAMR) of renal allografts has recently been recognized as a defined nosologic entity. The outcome of CAMR is poor; there is no established treatment protocol for this cond...
- Feasibility of Diagnosing Subclinical Renal Allograft Rejection in Children By Whole Blood Gene Expression Analysis
[作者:Alakulppi, N; Seikku, P; Jaatinen, T; Holmberg, C; Laine, J,期刊:Transplantation, 页码:1222-1228 , 文章类型: Article,,卷期:2008年86-9]
- Background. Protocol biopsies are used to monitor allograft histology after transplantation. However, biopsy is an invasive procedure with potential complications, requires special facilities, and is unpractical for repe...
- Reported Isolated Pancreas Rejection Is Associated With Poor Kidney Outcomes in Recipients of a Simultaneous Pancreas Kidney Transplant
[作者:Kaplan, B; West-Thielke, P; Herren, H; Gill, J; Knoll, GA; Oberholzer, J; Sankary, H; Benedetti, E,期刊:Transplantation, 页码:1229-1233 , 文章类型: Article,,卷期:2008年86-9]
- Background. We hypothesized that many reported and presumed isolated pancreas acute rejection episodes in simultaneous pancreas kidney patients may in fact be missed concordant kidney acute rejection episodes.Methods. To...
- Pharmacokinetics and Immunodynamics of Basiliximab in Pediatric Renal Transplant Recipients on Mycophenolate Mofetil Comedication
[作者:Hocker, B; Kovarik, JM; Daniel, V; Opelz, G; Fehrenbach, H; Holder, M; Hoppe, B; Hoyer, P; Jungraithmayr, TC; Kopf-Shakib, S; Laube, GF; Muller-Wiefel, DE; Offner, G; Plank, C; Schroder, M; Weber, LT; Zimmerhackl, LB; Tonshoff, B,期刊:Transplantation, 页码:1234-1240 , 文章类型: Article,,卷期:2008年86-9]
- Background. The aim of this substudy within a prospective, multicenter, placebo-controlled trial was to assess the pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on comedicati...
- Efficacy and Safety of Basiliximab in Pediatric Renal Transplant Patients Receiving Cyclosporine, Mycophenolate Mofetil, and Steroids
[作者:Offner, G; Toenshoff, B; Hocker, B; Krauss, M; Bulla, M; Cochat, P; Fehrenbach, H; Fischer, W; Foulard, M; Hoppe, B; Hoyer, PF; Jungraithmayr, TC; Klaus, G; Latta, K; Leichter, H; Mihatsch, MJ; Misselwitz, J; Montoya, C; Mueller-Wiefel, DE; Neuhaus, TJ; Pape, L; Querfeld, U; Plank, C; Schwarke, D; Wygoda, S; Zimmerhackl, LB,期刊:Transplantation, 页码:1241-1248 , 文章类型: Article,,卷期:2008年86-9]
- Background. Basiliximab, a monoclonal CD25 antibody has proofed effective in reducing acute rejection episodes in adults in various immunosuppressive regimens. The effect of basiliximab in the pediatric population is con...
- Comparison of CT Angiography With MR Angiography in the Preoperative Assessment of Living Kidney Donors
[作者:Gluecker, TM; Mayr, M; Schwarz, J; Bilecen, D; Voegele, T; Steiger, J; Bachmann, A; Bongartz, G,期刊:Transplantation, 页码:1249-1256 , 文章类型: Article,,卷期:2008年86-9]
- Background. The aim of the Study was to prospectively compare the diagnostic performance of CT angiography (CTA) with MR angiography (MRA) in the preoperative assessment of living renal donors.Methods. Forty-eight potent...
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