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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   From DNA binding to metabolic control: integration of -omics data reveals drug targets for prostate cancer [作者：Gao, H; Dahlman-Wright, K,期刊：EMBO journal, 页码：2516-2517 , 文章类型： Editorial Material，,卷期：2011年30-13] Androgen signalling via the androgen receptor plays a critical role in prostate cancer development and is the primary drug target for prostate cancer therapy. However, given the frequent development of resistance to curr... Understanding cargo specificity in intraflagellar transport [作者：Parker, DS; Katsanis, N,期刊：EMBO journal, 页码：2518-2519 , 文章类型： Editorial Material，,卷期：2011年30-13] Cilia biogenesis and maintenance depends on intraflagellar transport (IFT) that at the same time mediates shuttling of cell-type-specific cargo. Mechanistic understanding of how the general IFT transport machinery links ... Cellular stress response pathways and ageing: intricate molecular relationships [作者：Kourtis, N; Tavernarakis, N,期刊：EMBO journal, 页码：2520-2531 , 文章类型： Review，,卷期：2011年30-13] Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules vital for proper cellular function. Although this process is fundamentally haphazard and uncontrollable, senescent decline and agei... Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos [作者：Zhao, CT; Malicki, J,期刊：EMBO journal, 页码：2532-2544 , 文章类型： Article，,卷期：2011年30-13] Cilia are required for the development and function of many organs. Efficient transport of protein cargo along ciliary axoneme is necessary to sustain these processes. Despite its importance, the mode of interaction betw... Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria [作者：Bonn, F; Tatsuta, T; Petrungaro, C; Riemer, J; Langer, T,期刊：EMBO journal, 页码：2545-2556 , 文章类型： Article，,卷期：2011年30-13] m-AAA proteases exert dual functions in the mitochondrial inner membrane: they mediate the processing of specific regulatory proteins and ensure protein quality control degrading misfolded polypeptides to peptides. Loss ... Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins [作者：Lima-Fernandes, E; Enslen, H; Camand, E; Kotelevets, L; Boularan, C; Achour, L; Benmerah, A; Gibson, LCD; Baillie, GS; Pitcher, JA; Chastre, E; Etienne-Manneville, S; Marullo, S; Scott, MGH,期刊：EMBO journal, 页码：2557-2568 , 文章类型： Article，,卷期：2011年30-13] The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) regulates major cellular functions via lipid phosphatase-dependent and -independent mechanisms. Despite its fundamental pathophysiological impo... AP-2 gamma regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription [作者：Tan, SK; Lin, ZH; Chang, CW; Varang, V; Chng, KR; Pan, YF; Yong, EL; Sung, WK; Cheung, E,期刊：EMBO journal, 页码：2569-2581 , 文章类型： Article，,卷期：2011年30-13] Oestrogen receptor a (ER alpha) is key player in the progression of breast cancer. Recently, the cistrome and interactome of ER alpha were mapped in breast cancer cells, revealing the importance of spatial organization i... Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression [作者：Kanki, Y; Kohro, T; Jiang, SY; Tsutsumi, S; Mimura, I; Suehiro, J; Wada, Y; Ohta, Y; Ihara, S; Iwanari, H; Naito, M; Hamakubo, T; Aburatani, H; Kodama, T; Minami, T,期刊：EMBO journal, 页码：2582-2595 , 文章类型： Article，,卷期：2011年30-13] GATA2 is well recognized as a key transcription factor and regulator of cell-type specificity and differentiation. Here, we carried out comparative chromatin immunoprecipitation with comprehensive sequencing (ChIP-seq) t... The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [作者：Ryan, DP; Sundaramoorthy, R; Martin, D; Singh, V; Owen-Hughes, T,期刊：EMBO journal, 页码：2596-2609 , 文章类型： Article，,卷期：2011年30-13] The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain. Here, we show the DNA-binding domain is requi... A dual role of H4K16 acetylation in the establishment of yeast silent chromatin [作者：Oppikofer, M; Kueng, S; Martino, F; Soeroes, S; Hancock, SM; Chin, JW; Fischle, W; Gasser, SM,期刊：EMBO journal, 页码：2610-2621 , 文章类型： Article，,卷期：2011年30-13] Discrete regions of the eukaryotic genome assume heritable chromatin structure that is refractory to transcription. In budding yeast, silent chromatin is characterized by the binding of the Silent Information Regulatory ... An RNA-protein complex links enhanced nuclear 3 ' processing with cytoplasmic mRNA stabilization [作者：Ji, XJ; Kong, J; Liebhaber, SA,期刊：EMBO journal, 页码：2622-2633 , 文章类型： Article，,卷期：2011年30-13] Post-transcriptional controls are critical to gene regulation. These controls are frequently based on sequence-specific binding of trans-acting proteins to cis-acting motifs on target RNAs. Prior studies have revealed th... Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 [作者：Bertran, MT; Sdelci, S; Regue, L; Avruch, J; Caelles, C; Roig, J,期刊：EMBO journal, 页码：2634-2647 , 文章类型： Article，,卷期：2011年30-13] The NIMA-family kinases Nek9/Nercc1, Nek6 and Nek7 form a signalling module required for mitotic spindle assembly. Nek9, the upstream kinase, is activated during prophase at centrosomes although the details of this have ... Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles [作者：De Souza, CP; Hashmi, SB; Yang, XR; Osmani, SA,期刊：EMBO journal, 页码：2648-2661 , 文章类型： Article，,卷期：2011年30-13] The spindle assembly checkpoint (SAC) arrests mitosis until bipolar attachment of spindle microtubules to all chromosomes is accomplished. However, when spindle formation is prevented and the SAC cannot be satisfied, mam... Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis [作者：Lee, K; Gjorevski, N; Boghaert, E; Radisky, DC; Nelson, CM,期刊：EMBO journal, 页码：2662-2674 , 文章类型： Article，,卷期：2011年30-13] Several E-box-binding transcription factors regulate individual and collective cell migration and enhance the motility of epithelial cells by promoting epithelial-mesenchymal transition (EMT). Here, we characterized the ... SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 [作者：Cui, Y; He, S; Xing, CC; Lu, KF; Wang, J; Xing, GC; Meng, AM; Jia, SJ; He, FC; Zhang, LQ,期刊：EMBO journal, 页码：2675-2689 , 文章类型： Article，,卷期：2011年30-13] Smad ubiquitination regulatory factor 1 (Smurf1), an homologous to E6AP C-terminus (HECT)-type E3 ubiquitin ligase, performs a crucial role in the regulation of the bone morphogenetic protein (BMP) signalling pathway in ... Id2 expression delineates differential checkpoints in the genetic program of CD8 alpha(+) and CD103(+) dendritic cell lineages [作者：Jackson, JT; Hu, YF; Liu, RJ; Masson, F; D'Amico, A; Carotta, S; Xin, A; Camilleri, MJ; Mount, AM; Kallies, A; Wu, L; Smyth, GK; Nutt, SL; Belz, GT,期刊：EMBO journal, 页码：2690-2704 , 文章类型： Article，,卷期：2011年30-13] Dendritic cells (DCs) have critical roles in the induction of the adaptive immune response. The transcription factors Id2, Batf3 and Irf-8 are required for many aspects of murine DC differentiation including development ...