- Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8
[作者:Braun, D; Wirth, EK; Wohlgemuth, F; Reix, N; Klein, MO; Gruters, A; Kohrle, J; Schweizer, U,期刊:Biochemical Journal, 页码:249-255 , 文章类型: Article,,卷期:2011年439-2]
- LAT2 (system L amino acid transporter 2) is composed of the subunits Slc7a8/Lat2 and Slc3a2/4F2hc. This transporter is highly expressed along the basolateral membranes of absorptive epithelia in kidney and small intestin...
- Structural and mechanistic insight into the ferredoxin-mediated two-electron reduction of bilins
[作者:Busch, AWU; Reijerse, EJ; Lubitz, W; Frankenberg-Dinkel, N; Hofmann, E,期刊:Biochemical Journal, 页码:257-264 , 文章类型: Article,,卷期:2011年439-2]
- PEB (phycoerythrobilin) is one of the major open-chain tetrapyrrole molecules found in cyanobacterial light-harvesting phycobiliproteins. In these organisms, two enzymes of the ferredoxin-dependent bilin reductase family...
- Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser(25) by AMP-activated protein kinase
[作者:Roma-Mateo, C; Solaz-Fuster, MD; Gimeno-Alcaniz, JV; Dukhande, VV; Donderis, J; Worby, CA; Marina, A; Criado, O; Koller, A; De Cordoba, SR; Gentry, MS; Sanz, P,期刊:Biochemical Journal, 页码:265-275 , 文章类型: Article,,卷期:2011年439-2]
- Lafora progressive myoclonus epilepsy [LD (Lafora disease)] is a fatal, autosomal recessive neurodegenerative disorder caused by loss-of-function mutations in either the EPM2A gene, encoding the dual-specificity phosphat...
- 1(2)01810 is a novel type of glutamate transporter that is responsible for megamitochondrial formation
[作者:Shim, MS; Kim, JY; Lee, KH; Jung, HK; Carlson, BA; Xu, XM; Hatfield, DL; Lee, BJ,期刊:Biochemical Journal, 页码:277-286 , 文章类型: Article,,卷期:2011年439-2]
- 1(2)01810 causes glutamine-,dependent megamitochondrial formation when it is overexpressed in Drosophila cells. In the present study, we elucidated the function of 1(2)01810 during megamitochondrial formation. The overex...
- mTORC2 targets AGC kinases through Sin1-dependent recruitment
[作者:Cameron, AJM; Linch, MD; Saurin, AT; Escribano, C; Parker, PJ,期刊:Biochemical Journal, 页码:287-297 , 文章类型: Article,,卷期:2011年439-2]
- The protein kinase TOR (target of rapamycin) is a key regulator of cell growth and metabolism with significant clinical relevance. In mammals, TOR signals through two distinct multi-protein complexes, mTORC1 and mTORC2 (...
- Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
[作者:Rosales, KR; Singh, G; Wu, K; Chen, J; Janes, MR; Lilly, MB; Peralta, ER; Siskind, LJ; Bennett, MJ; Fruman, DA; Edinger, AL,期刊:Biochemical Journal, 页码:299-311 , 文章类型: Article,,卷期:2011年439-2]
- Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and TCA (tricarboxylic acid) cycle intermediates into biosynthetic pathways. As the anaplerotic reactions that repl...
- Varying dependency of periplasmic peptidylprolyl cis-trans isomerases in promoting Yersinia pseudotuberculosis stress tolerance and pathogenicity
[作者:Obi, IR; Nordfelth, R; Francis, MS,期刊:Biochemical Journal, 页码:321-332 , 文章类型: Article,,卷期:2011年439-2]
- Periplasmic PPIases (peptidylprolyl cis-trans isomerases) catalyse the cis-trans isomerization of peptidyl-prolyl bonds, which is a rate-limiting step during protein folding. We demonstrate that the surA, ppiA, ppiD, fkp...
- Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1
[作者:Vandenberg, RJ; Handford, CA; Campbell, EM; Ryan, RM; Yool, AJ,期刊:Biochemical Journal, 页码:333-340 , 文章类型: Article,,卷期:2011年439-2]
- Glutamate transport is coupled to the co-transport of 3 Na(+) and 1 H(+) followed by the counter-transport of 1 K(+). In addition, glutamate and Na(+) binding to glutamate transporters generates an uncoupled anion conduc...
- Pathway analysis of NAD(+) metabolism
[作者:de Figueiredo, LF; Gossmann, TI; Ziegler, M; Schuster, S,期刊:Biochemical Journal, 页码:341-348 , 文章类型: Article,,卷期:2011年439-2]
- NAD(+) is well known as a crucial cofactor in the redox balance of metabolism. Moreover, NAD(+) is degraded in ADP-ribosyl transfer reactions, which are important components of multitudinous signalling reactions. These i...
- Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions
[作者:Gaboriaud, C; Gregory-Pauron, L; Teillet, F; Thielens, NM; Bally, I; Arlaud, GJ,期刊:Biochemical Journal, 页码:185-193 , 文章类型: Review,,卷期:2011年439-2]
- CUB domains are 110-residue protein motifs exhibiting a beta-sandwich fold and mediating protein-protein interactions in various extracellular proteins. Recent X-ray structural and mutagenesis studies have led to the ide...
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