- beta-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development
[作者：Tipping, M; Kim, Y; Kyriakakis, P; Tong, M; Shvartsman, SY; Veraksa, A,期刊：EMBO journal, 页码：3222-3235 , 文章类型： Article，,卷期：2010年29-19]
- beta-Arrestins have been implicated in the regulation of multiple signalling pathways. However, their role in organism development is not well understood. In this study, we report a new in vivo function of the Drosophila...
- Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/beta-catenin signalling
[作者：Abu-Remaileh, M; Gerson, A; Farago, M; Nathan, G; Alkalay, I; Rousso, SZ; Gur, M; Fainsod, A; Bergman, Y,期刊：EMBO journal, 页码：3236-3248 , 文章类型： Article，,卷期：2010年29-19]
- Although the transcriptional regulatory events triggered by Oct-3/4 are well documented, understanding the proteomic networks that mediate the diverse functions of this POU domain homeobox protein remains a major challen...
- Molecular basis for activation of G protein-coupled receptor kinases
[作者：Boguth, CA; Singh, P; Huang, CC; Tesmer, JJG,期刊：EMBO journal, 页码：3249-3259 , 文章类型： Article，,卷期：2010年29-19]
- G protein-coupled receptor (GPCR) kinases (GRKs) selectively recognize and are allosterically regulated by activated GPCRs, but the molecular basis for this interaction is not understood. Herein, we report crystal struct...
- A multiprotein complex necessary for both transcription and DNA replication at the beta-globin locus
[作者：Karmakar, S; Mahajan, MC; Schulz, V; Boyapaty, G; Weissman, SM,期刊：EMBO journal, 页码：3260-3271 , 文章类型： Article，,卷期：2010年29-19]
- DNA replication, repair, transcription and chromatin structure are intricately associated nuclear processes, but the molecular links between these events are often obscure. In this study, we have surveyed the protein com...
- The potential functions of primary microRNAs in target recognition and repression
[作者：Trujillo, RD; Yue, SB; Tang, YJ; O'Gorman, WE; Chen, CZ,期刊：EMBO journal, 页码：3272-3285 , 文章类型： Article，,卷期：2010年29-19]
- Major RNA products of a microRNA (miRNA) gene-the long primary transcript (pri-miRNA), the similar to 70-nucleotide (nt) precursor miRNA (pre-miRNA), and the similar to 21-nt mature miRNA-all contain the same sequence re...
- An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition
[作者：Warzecha, CC; Jiang, P; Amirikian, K; Dittmar, KA; Lu, HZ; Shen, SH; Guo, W; Xing, Y; Carstens, RP,期刊：EMBO journal, 页码：3286-3300 , 文章类型： Article，,卷期：2010年29-19]
- Alternative splicing achieves coordinated changes in post-transcriptional gene expression programmes through the activities of diverse RNA-binding proteins. Epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP...
- An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila
[作者：Olivieri, D; Sykora, MM; Sachidanandam, R; Mechtler, K; Brennecke, J,期刊：EMBO journal, 页码：3301-3317 , 文章类型： Article，,卷期：2010年29-19]
- In Drosophila, PIWI proteins and bound PIWI-interacting RNAs (piRNAs) form the core of a small RNA-mediated defense system against selfish genetic elements. Within germline cells, piRNAs are processed from piRNA clusters...
- Disulphide production by Ero1 alpha-PDI relay is rapid and effectively regulated
[作者：Appenzeller-Herzog, C; Riemer, J; Zito, E; Chin, KT; Ron, D; Spiess, M; Ellgaard, L,期刊：EMBO journal, 页码：3318-3329 , 文章类型： Article，,卷期：2010年29-19]
- The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is resto...
- Crystal structures of human Ero1 alpha reveal the mechanisms of regulated and targeted oxidation of PDI
[作者：Inaba, K; Masui, S; Iida, H; Vavassori, S; Sitia, R; Suzuki, M,期刊：EMBO journal, 页码：3330-3343 , 文章类型： Article，,卷期：2010年29-19]
In the endoplasmic reticulum (ER) of eukaryotic cells, Ero1 flavoenzymes promote oxidative protein folding through protein disulphide isomerase (PDI), generating reactive oxygen species (hydrogen peroxide) as byproduc...
- Proteomic and functional analysis of the mitotic Drosophila centrosome
[作者：Muller, H; Schmidt, D; Steinbrink, S; Mirgorodskaya, E; Lehmann, V; Habermann, K; Dreher, F; Gustavsson, N; Kessler, T; Lehrach, H; Herwig, R; Gobom, J; Ploubidou, A; Boutros, M; Lange, BMH,期刊：EMBO journal, 页码：3344-3357 , 文章类型： Article，,卷期：2010年29-19]
- Regulation of centrosome structure, duplication and segregation is integrated into cellular pathways that control cell cycle progression and growth. As part of these pathways, numerous proteins with well-established non-...
- Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
[作者：Mimitou, EP; Symington, LS,期刊：EMBO journal, 页码：3358-3369 , 文章类型： Article，,卷期：2010年29-19]
- In this study, we investigate the interplay between Ku, a central non-homologous end-joining component, and the Mre11-Rad50-Xrs2 (MRX) complex and Sae2, end-processing factors crucial for initiating 5'-3' resection of do...
- Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
[作者：Shim, EY; Chung, WH; Nicolette, ML; Zhang, Y; Davis, M; Zhu, Z; Paull, TT; Ira, G; Lee, SE,期刊：EMBO journal, 页码：3370-3380 , 文章类型： Article，,卷期：2010年29-19]
- Single-stranded DNA constitutes an important early intermediate for homologous recombination and damage-induced cell cycle checkpoint activation. In Saccharomyces cerevisiae, efficient double-strand break (DSB) end resec...
- Molecular architecture of the DNA replication origin activation checkpoint
[作者：Tudzarova, S; Trotter, MWB; Wollenschlaeger, A; Mulvey, C; Godovac-Zimmermann, J; Williams, GH; Stoeber, K,期刊：EMBO journal, 页码：3381-3394 , 文章类型： Article，,卷期：2010年29-19]
- Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication initiation and dissect this checkpoint in fi...
- The nuclear receptor PPAR gamma individually responds to serotonin- and fatty acid-metabolites
[作者：Waku, T; Shiraki, T; Oyama, T; Maebara, K; Nakamori, R; Morikawa, K,期刊：EMBO journal, 页码：3395-3407 , 文章类型： Article，,卷期：2010年29-19]
- The nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma), recognizes various synthetic and endogenous ligands by the ligand-binding domain. Fatty-acid metabolites reportedly activate PPAR gamma...
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