- TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
[作者：Grosse-Wilde, A; Voloshanenko, O; Bailey, SL; Longton, GM; Schaefer, U; Csernok, AI; Schutz, G; Greiner, EF; Kemp, CJ; Walczak, H,期刊：Journal of clinical investigation, 页码：100-110 , 文章类型： Article，,卷期：2008年118-1]
- TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in established tumor cell lines but not nontransformed cells. Herein, we demonstrate a role for the apoptosis-inducing TRAIL recept...
- The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice
[作者：Kim, Y; Phan, D; Van Rooij, E; Wang, DZ; McAnally, J; Qi, XX; Richardson, JA; Hill, JA; Bassel-Duby, R; Olson, EN,期刊：Journal of clinical investigation, 页码：124-132 , 文章类型： Article，,卷期：2008年118-1]
- The adult heart responds to excessive neurohumoral signaling and workload by a pathological growth response characterized by hypertrophy of cardiomyocytes and activation of a fetal program of cardiac gene expression. The...
- Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke
[作者：Shyu, WC; Lin, SZ; Chiang, MF; Chen, DC; Su, CY; Wang, HJ; Liu, RS; Tsai, CH; Li, H,期刊：Journal of clinical investigation, 页码：133-148 , 文章类型： Article，,卷期：2008年118-1]
- Secretoneurin (SN), a neuropeptide derived from secretogranin II, promotes neurite outgrowth of immature cerebellar granule cells. SN also aids in the growth and repair of neuronal tissue, although the precise mechanisms...
- Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
[作者：Parish, CL; Castelo-Branco, G; Rawal, N; Tonnesen, J; Sorensen, AT; Salto, C; Kokaia, M; Lindvall, O; Arenas, E,期刊：Journal of clinical investigation, 页码：149-160 , 文章类型： Article，,卷期：2008年118-1]
- Dopamine (DA) cell replacement therapy in Parkinson disease (PD) can be achieved using human fetal mesencephalic tissue; however, limited tissue availability has hindered further developments. Embryonic stem cells provid...
- A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents
[作者：Gaultier, A; Arandjelovic, S; Li, XQ; Janes, J; Dragojlovic, N; Zhou, GP; Dolkas, J; Myers, RR; Gonias, SL; Campana, WM,期刊：Journal of clinical investigation, 页码：161-172 , 文章类型： Article，,卷期：2008年118-1]
- Injury to the peripheral nervous system (PNS) initiates a response controlled by multiple extracellular mediators, many of which contribute to the development of neuropathic pain. Schwann cells in an injured nerve demons...
- Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP
[作者：Park, HJ; Georgescu, SP; Du, C; Madias, C; Aronovitz, MJ; Welzig, CM; Wang, B; Begley, U; Zhang, YL; Blaustein, RO; Patten, RD; Karas, RH; Van Tol, HH; Osborne, TF; Shimano, H; Liao, R; Link, MS; Galper, JB,期刊：Journal of clinical investigation, 页码：259-271 , 文章类型： Article，,卷期：2008年118-1]
- Parasympathetic stimulation of the heart, which provides protection from arrhythmias and sudden death, involves activation of the G protein-coupled inward rectifying K channel GIRK1/4 and results in an acetylcholine-sens...
- Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents
[作者：Xu, L; Rensing, N; Yang, XF; Zhang, HX; Thio, LL; Rothman, SM; Weisenfeld, AE; Wong, M; Yamada, KA,期刊：Journal of clinical investigation, 页码：272-280 , 文章类型： Article，,卷期：2008年118-1]
- Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized that leptin receptor activation in other ne...
- Small intestinal CD8(+)TCR gamma delta(+)NKG2A(+) intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease
[作者：Bhagat, G; Naiyer, AJ; Shah, JG; Harper, J; Jabri, B; Wang, TC; Green, PHR; Manavalan, JS,期刊：Journal of clinical investigation, 页码：281-293 , 文章类型： Article，,卷期：2008年118-1]
- Intraepithelial lymphocytes (IELs) bearing the gamma delta TCR are more abundant in the small intestinal mucosa of patients with celiac disease (CD) compared with healthy individuals. However, their role in disease patho...
- Adoptive transfer of effector CD8(+) T cells derived from central memory cells establishes persistent T cell memory in primates
[作者：Berger, C; Jensen, MC; Lansdorp, PM; Gough, M; Elliott, C; Riddell, SR,期刊：Journal of clinical investigation, 页码：294-305 , 文章类型： Article，,卷期：2008年118-1]
- The adoptive transfer of antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in humans. The T cell populations that are available for adoptive immunothera...
- Sustained pharmacological inhibition of delta PKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
[作者：Qi, X; Inagaki, K; Sobel, RA; Mochly-Rosen, D,期刊：Journal of clinical investigation, 页码：173-182 , 文章类型： Article，,卷期：2008年118-1]
- Hypertensive encephalopathy is a potentially fatal condition associated with cerebral edema and the breakdown of the blood-brain barrier (BBB). The molecular pathways leading to this condition, however, are unknown. We d...
- Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE(-/-) mice
[作者：Harja, E; Bu, DX; Hudson, BI; Chang, JS; Shen, XP; Hallam, K; Kalea, AZ; Lu, Y; Rosario, RH; Oruganti, S; Nikolla, Z; Belov, D; Lalla, E; Ramasamy, R; Yan, SF; Schmidt, AM,期刊：Journal of clinical investigation, 页码：183-194 , 文章类型： Article，,卷期：2008年118-1]
- Endothelial dysfunction is a key triggering event in atherosclerosis. Following the entry of lipoproteins into the vessel wall, their rapid modification results in the generation of advanced glycation endproduct epitopes...
- Phospholipase C beta 3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
[作者：Wang, ZL; Liu, B; Wang, P; Dong, XM; Fernandez-Hernando, C; Li, Z; Hla, T; Li, ZH; Claffey, K; Smith, JD; Wu, DQ,期刊：Journal of clinical investigation, 页码：195-204 , 文章类型： Article，,卷期：2008年118-1]
- Atherosclerosis is an inflammatory disease that is associated with monocyte recruitment and subsequent differentiation into lipid-laden macrophages at sites of arterial lesions, leading to the development of atherosclero...
- Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
[作者：Abdollahi-Roodsaz, S; Joosten, LAB; Koenders, MI; Devesa, I; Roelofs, MF; Radstake, TRDJ; Heuvelmans-Jacobs, M; Akira, S; Nicklin, MJH; Ribeiro-Dias, F; Van den Berg, WB,期刊：Journal of clinical investigation, 页码：205-216 , 文章类型： Article，,卷期：2008年118-1]
- TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host-derived ligands found in arthritic joints. Here, we show that TLR2 and TLR4, but not TLR9, are involved in the patho...
- Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo
[作者：Sjoelund, J; Johansson, M; Manna, S; Norin, C; Pietras, A; Beckman, S; Nilsson, E; Ljungberg, B; Axelson, H,期刊：Journal of clinical investigation, 页码：217-228 , 文章类型： Article，,卷期：2008年118-1]
- Loss of the tumor suppressor gene von Hippel-Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to stabilization of the HIF transcription complex, which induces an...
- Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function
[作者：Bode, L; Salvestrini, C; Park, PW; Li, JP; Esko, JD; Yamaguchi, Y; Murch, S; Freeze, HH,期刊：Journal of clinical investigation, 页码：229-238 , 文章类型： Article，,卷期：2008年118-1]
- Patients with protein-losing enteropathy (PLE) fail to maintain intestinal epithelial barrier function and develop an excessive and potentially fatal efflux of plasma proteins. PLE occurs in ostensibly unrelated diseases...
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