- TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice
[作者:Reinert, LS; Harder, L; Holm, CK; Iversen, MB; Horan, KA; Dagnaes-Hansen, F; Ulhoi, BP; Holm, TH; Mogensen, TH; Owens, T; Nyengaard, JR; Thomsen, AR; Paludan, SR,期刊:Journal of clinical investigation, 页码:1368-1376 , 文章类型: Article,,卷期:2012年122-4]
- Herpes simplex viruses (HSVs) are highly prevalent neurotropic viruses. While they can replicate lytically in cells of the epithelial lineage, causing lesions on mucocutaneous surfaces, HSVs also establish latent infecdo...
- A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease
[作者:Deane, R; Singh, I; Sagare, AP; Bell, RD; Ross, NT; LaRue, B; Love, R; Perry, S; Paquette, N; Deane, RJ; Thiyagarajan, M; Zarcone, T; Fritz, G; Friedman, AE; Miller, BL; Zlokovic, BV,期刊:Journal of clinical investigation, 页码:1377-1392 , 文章类型: Article,,卷期:2012年122-4]
- In Alzheimer disease (AD), amyloid beta peptide (A beta) accumulates in plaques in the brain. Receptor for advanced glycation end products (RAGE) mediates A beta-induced perturbations in cerebral vessels, neurons, and mi...
- Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity
[作者:Maurer, MA; Rakocevic, G; Leung, CS; Quast, I; Lukacisin, M; Goebels, N; Munz, C; Wardemann, H; Dalakas, M; Lunemann, JD,期刊:Journal of clinical investigation, 页码:1393-1402 , 文章类型: Article,,卷期:2012年122-4]
- The B cell-depleting IgG1 monoclonal antibody rituximab can persistently suppress disease progression in some patients with autoimmune diseases. However, the mechanism underlying these long-term beneficial effects has re...
- Evidence for a stepwise program of extrathymic T cell development within the human tonsil
[作者:McClory, S; Hughes, T; Freud, AG; Briercheck, EL; Martin, C; Trimboli, AJ; Yu, JH; Zhang, XL; Leone, G; Nuovo, G; Caligiuri, MA,期刊:Journal of clinical investigation, 页码:1403-1415 , 文章类型: Article,,卷期:2012年122-4]
- The development of a broad repertoire of T cells, which is essential for effective immune function, occurs in the thymus. Although some data suggest that T cell development can occur extrathymically, many researchers rem...
- The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
[作者:Fukuhara, S; Simmons, S; Kawamura, S; Inoue, A; Orba, Y; Tokudome, T; Sunden, Y; Arai, Y; Moriwaki, K; Ishida, J; Uemura, A; Kiyonari, H; Abe, T; Fukamizu, A; Hirashima, M; Sawa, H; Aoki, J; Ishii, M; Mochizuki, N,期刊:Journal of clinical investigation, 页码:1416-1426 , 文章类型: Article,,卷期:2012年122-4]
- The bioactive lysophospholipid mediator sphingosine-l-phosphate (SIP) promotes the egress of newly formed T cells from the thymus and the release of immature B cells from the bone marrow. It has remained unclear, however...
- Endothelial HIF-2 alpha regulates murine pathological angiogenesis and revascularization processes
[作者:Skuli, N; Majmundar, AJ; Krock, BL; Mesquita, RC; Mathew, LK; Quinn, ZL; Runge, A; Liu, LP; Kim, MN; Liang, JM; Schenkel, S; Yodh, AG; Keith, B; Simon, MC,期刊:Journal of clinical investigation, 页码:1427-1443 , 文章类型: Article,,卷期:2012年122-4]
- Localized tissue hypoxia is a consequence of vascular compromise or rapid cellular proliferation and is a potent inducer of compensatory angiogenesis. The oxygen-responsive transcriptional regulator hypoxia-inducible fac...
- Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
[作者:Baek, JH; D'Agnillo, F; Vallelian, F; Pereira, CP; Williams, MC; Jia, YP; Schaer, DJ; Buehler, PW,期刊:Journal of clinical investigation, 页码:1444-1458 , 文章类型: Article,,卷期:2012年122-4]
- Massive transfusion of blood can lead to clinical complications, including multiorgan dysfunction and even death. Such severe clinical outcomes have been associated with longer red blood cell (rbc) storage times. Collect...
- Niacin and biosynthesis of PGD(2) by platelet COX-1 in mice and humans
[作者:Song, WL; Stubbe, J; Ricciotti, E; Alamuddin, N; Ibrahim, S; Crichton, I; Prempeh, M; Lawson, JA; Wilensky, RL; Rasmussen, LM; Pure, E; FitzGerald, GA,期刊:Journal of clinical investigation, 页码:1459-1468 , 文章类型: Article,,卷期:2012年122-4]
- The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1-dependent formation of PGD(2) and PGE(2) ...
- G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
[作者:Dong, CF; Wu, YD; Yao, J; Wang, YF; Yu, YH; Rychahou, PG; Evers, BM; Zhou, BP,期刊:Journal of clinical investigation, 页码:1469-1486 , 文章类型: Article,,卷期:2012年122-4]
- Breast cancers are highly heterogeneous but can be grouped into subtypes based on several criteria, including level of expression of certain markers. Claudin-low breast cancer (CLBC) is associated with early metastasis a...
- EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors
[作者:White, RE; Ramer, PC; Naresh, KN; Meixlsperger, S; Pinaud, L; Rooney, C; Savoldo, B; Coutinho, R; Bodor, C; Gribben, J; Ibrahim, HA; Bower, M; Nourse, JP; Gandhi, MK; Middeldorp, J; Cader, FZ; Murray, P; Munz, C; Allday, MJ,期刊:Journal of clinical investigation, 页码:1487-1502 , 文章类型: Article,,卷期:2012年122-4]
- Epstein-Barr virus (EBV) persistently infects more than 90% of the human population and is etiologically linked to several B cell malignancies, including Burkitt lymphoma (BL), Hodgkin lymphoma (HL), and diffuse large B ...
- An NF-kappa B pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice
[作者:Daniluk, J; Liu, Y; Deng, DF; Chu, J; Huang, HJ; Gaiser, S; Cruz-Monserrate, Z; Wang, HM; Ji, BA; Logsdon, CD,期刊:Journal of clinical investigation, 页码:1519-1528 , 文章类型: Article,,卷期:2012年122-4]
- Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such mutations are not clear biomarkers for disease, since they are frequently detected in health...
- beta(1) Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy
[作者:Eke, I; Deuse, Y; Hehlgans, S; Gurtner, K; Krause, M; Baumann, M; Shevchenko, A; Sandfort, V; Cordes, N,期刊:Journal of clinical investigation, 页码:1529-1540 , 文章类型: Article,,卷期:2012年122-4]
- Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting of beta(1) integrins with inhibitory antibodies enhances the sensitivity to i...
- Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
[作者:Ma, CX; Cai, SR; Li, SQ; Ryan, CE; Guo, ZF; Schaiff, WT; Lin, L; Hoog, J; Goiffon, RJ; Prat, A; Aft, RL; Ellis, MJ; Piwnica-Worms, H,期刊:Journal of clinical investigation, 页码:1541-1552 , 文章类型: Article,,卷期:2012年122-4]
- Patients with triple-negative breast cancer (TNBC) - defined by lack of estrogen receptor and progesterone receptor expression as well as lack of human epidermal growth factor receptor 2 (HER2) amplification - have a poo...
- c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains
[作者:Mueller, D; Tegtmeyer, N; Brandt, S; Yamaoka, Y; De Poire, E; Sgouras, D; Wessler, S; Torres, J; Smolka, A; Backert, S,期刊:Journal of clinical investigation, 页码:1553-1566 , 文章类型: Article,,卷期:2012年122-4]
- Many bacterial pathogens inject into host cells effector proteins that are substrates for host tyrosine kinases such as Src and Abl family kinases. Phosphorylated effectors eventually subvert host cell signaling, aiding ...
- Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
[作者:Wang, L; Wang, XD; Xie, GH; Wang, L; Hill, CK; De Leve, LD,期刊:Journal of clinical investigation, 页码:1567-1573 , 文章类型: Article,,卷期:2012年122-4]
- The ability of the liver to regenerate is crucial to protect liver function after injury and during chronic disease. Increases in hepatocyte growth factor (HGF) in liver sinusoidal endothelial cells (LSECs) are thought t...
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