- MicroRNA Expression Profiles Associated with Development of Drug Resistance in Ehrlich Ascites Tumor Cells
[作者:Husted, S; Sokilde, R; Rask, L; Cirera, S; Busk, PK; Eriksen, J; Litman, T,期刊:Molecular Pharmaceutics, 页码:2055-2062 , 文章类型: Article,,卷期:2011年8-6]
- Multidrug resistance (MDR) poses a major obstacle to successful chemotherapeutic treatment of cancer, and often involves multiple genes, which may be regulated post-transcriptionally by microRNAs (miRNIAs). The purpose o...
- The Goldilocks Principle and Antibiotic Resistance in Bacteria
[作者:Zhang, QC; Robin, K; Liao, D; Lambert, G; Austin, RH,期刊:Molecular Pharmaceutics, 页码:2063-2068 , 文章类型: Article,,卷期:2011年8-6]
- We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possibl...
- Histone Deacetylase Inhibitors: Emerging Mechanisms of Resistance
[作者:Robey, RW; Chakraborty, AR; Basseville, A; Luchenko, V; Bahr, J; Zhan, ZR; Bates, SE,期刊:Molecular Pharmaceutics, 页码:2021-2031 , 文章类型: Review,,卷期:2011年8-6]
- The histone deacetylase inhibitors (HDIs) have shown promise in the treatment of a number of hematologic malignancies, leading to the approval of vorinostat and romidepsin for the treatment of cutaneous T-cell lymphoma a...
- Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment
[作者:Wojtkowiak, JW; Verduzco, D; Schramm, KJ; Gillies, RJ,期刊:Molecular Pharmaceutics, 页码:2032-2038 , 文章类型: Review,,卷期:2011年8-6]
- Despite advances in developing novel therapeutic strategies, a major factor underlying cancer related death remains resistance to therapy. In addition to biochemical resistance, mediated by xenobiotic transporters or bin...
- Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance
[作者:Flach, EH; Rebecca, VW; Herlyn, M; Smalley, KSM; Anderson, ARA,期刊:Molecular Pharmaceutics, 页码:2039-2049 , 文章类型: Article,,卷期:2011年8-6]
- The role of tumor-stromal interactions in progression is generally well accepted, but their role in initiation or treatment is less well understood. It is now generally agreed that, rather than consisting solely of malig...
- Evaluation of 3,3 ',4 '-Trihydroxyflavone and 3,6,4 '-Trihydroxyflavone (4 '-O-Glucuronidation) as the in Vitro Functional Markers for Hepatic UGT1A1
[作者:Wu, BJ; Zhang, SX; Hu, M,期刊:Molecular Pharmaceutics, 页码:2379-2389 , 文章类型: Article,,卷期:2011年8-6]
- Identifying uridine 5'-diphospho-(UDP)-glucuronosyltransferase (UGT)-selective probes (substrates that are primarily glucuronidated by a single isoform) is complicited by the enzymes large overlapping substrate specifici...
- Therapeutic Strategies for Gaucher Disease: Miglustat (NB-DNJ) as a Pharmacological Chaperone for Glucocerebrosidase and the Different Thermostability of Velaglucerase Alfa and Imiglucerase
[作者:Abian, O; Alfonso, P; Velazquez-Campoy, A; Giraldo, P; Pocovi, M; Sancho, J,期刊:Molecular Pharmaceutics, 页码:2390-2397 , 文章类型: Article,,卷期:2011年8-6]
- Gaucher disease (GD) is a disorder of glycosphingolipid metabolism caused by deficiency of lysosomal glucocerebrosidase (GlcCerase) activity, due to conformationally or functionally defective variants, resulting in progr...
- Therapeutic and Cytotoxic Effects of the Novel Antipsoriasis Codrug, Naproxyl-Dithranol, on HaCaT Cells
[作者:Lau, WM; Ng, KW; White, AW; Heard, CM,期刊:Molecular Pharmaceutics, 页码:2398-2407 , 文章类型: Article,,卷期:2011年8-6]
- A novel topical codrug, naproxyl-dithranol (Nap-DTH), in which dithranol and naproxen are linked via an ester in a 1:1 ratio to form a single chemical entity, was synthesized. The antiproliferative, anti-inflammatory and...
- Biodegradable Microspheres Loaded with an Anti-Parkinson Prodrug: An in Vivo Pharmacokinetic Study
[作者:D'Aurizio, E; Sozio, P; Cerasa, LS; Vacca, M; Brunetti, L; Orlando, G; Chiavaroli, A; Kok, RJ; Hennink, WE; Di Stefano, A,期刊:Molecular Pharmaceutics, 页码:2408-2415 , 文章类型: Article,,卷期:2011年8-6]
- During chronic treatment with L-dopa (LD), Parkinsonian patients often experience uncontrolled motor complications due to fluctuations of the plasmatic levels of LD that result in pulsatile dopaminergic stimulation. To o...
- Bubble Liposomes and Ultrasound Promoted Endosomal Escape of TAT-PEG Liposomes as Gene Delivery Carriers
[作者:Omata, D; Negishi, Y; Hagiwara, S; Yamamura, S; Endo-Takahashi, Y; Suzuki, R; Maruyama, K; Nomizu, M; Aramaki, Y,期刊:Molecular Pharmaceutics, 页码:2416-2423 , 文章类型: Article,,卷期:2011年8-6]
- We have previously developed laminin-derived AG73 peptide-labeled poly(ethylene glycol)-modified liposomes (AG73-PEG liposomes) for selective cancer gene therapy and reported that Bubble liposomes (BLs) and ultrasound (U...
- New in Vitro Tools to Study Human Constitutive Androstane Receptor (CAR) Biology: Discovery and Comparison of Human CAR Inverse Agonists
[作者:Kublbeck, J; Jyrkkarinne, J; Molnar, F; Kuningas, T; Patel, J; Windshugel, B; Nevalainen, T; Laitinen, T; Sippl, W; Poso, A; Honkakoski, P,期刊:Molecular Pharmaceutics, 页码:2424-2433 , 文章类型: Article,,卷期:2011年8-6]
- The human constitutive androstane receptor (CAR. NR1I3) is one of the key regulators of xenobiotic and endobiotic metabolism. The unique properties of human CAR, such as the high constitutive activity and the complexity ...
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