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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共57条记录   Hematopoietic Stem Cell Gene Therapy as a Treatment for Autoimmune Diseases [作者：Alderuccio, F; Nasa, Z; Chung, JY; Ko, HJ; Chan, J; Toh, BH,期刊：Molecular Pharmaceutics, 页码：1488-1494 , 文章类型： Review，,卷期：2011年8-5] A key function of the immune system is to protect us from foreign pathogens such as viruses, bacteria, fungi and multicellular parasites. However, it is also important in many other aspects of human health such as cancer... Human Pluripotent Stem Cell-Based Approaches for Myocardial Repair: From the Electrophysiological Perspective [作者：Poon, E; Kong, CW; Li, RA,期刊：Molecular Pharmaceutics, 页码：1495-1504 , 文章类型： Review，,卷期：2011年8-5] Heart diseases are a leading cause of mortality worldwide. Terminally differentiated adult cardiomyocytes (CMs) lack the innate ability to regenerate. Their malfunction or significant loss can lead to conditions from car... Biosafety Assessment of Human Mesenchymal Stem Cells Engineered by Hybrid Baculovirus Vectors [作者：Chen, CY; Wu, HH; Chen, CP; Chern, SR; Hwang, SM; Huang, SF; Lo, WH; Chen, GY; Hu, YC,期刊：Molecular Pharmaceutics, 页码：1505-1514 , 文章类型： Article，,卷期：2011年8-5] Mesenchymal stem cells (MSCs) hold promise for cell therapy, and implantation of MSCs engineered with a baculovirus transiently expressing the growth factor can augment the bone repair. To prolong the baculovirus-mediate... Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells [作者：Lee, EXW; Lam, DH; Wu, CX; Yang, J; Tham, CK; Ng, WH; Wang, S,期刊：Molecular Pharmaceutics, 页码：1515-1524 , 文章类型： Article，,卷期：2011年8-5] Using neural stem cells (NSCs) with tumor tropic migratory capacity to deliver therapeutic genes is an attractive strategy in eliminating metastatic or disseminated tumors. While different methods have been developed to ... Development of Novel Efficient SIN Vectors with Improved Safety Features for Wiskott-Aldrich Syndrome Stem Cell Based Gene Therapy [作者：Diez, IA; Zychlinski, D; Coci, EG; Galla, M; Modlich, U; Dewey, RA; Schwarzer, A; Maetzig, T; Mpofu, N; Jaeckel, E; Boztug, K; Baum, C; Klein, C; Schambach, A,期刊：Molecular Pharmaceutics, 页码：1525-1537 , 文章类型： Article，,卷期：2011年8-5] Gene therapy is a promising therapeutic approach to treat primary immunodeficiencies. Indeed, the clinical trial for the Wiskott Aldrich Syndrome (WAS) that is currently ongoing at the Hannover Medical School (Germany) h... Interaction of Poly(ethylenimine)-DNA Polyplexes with Mitochondria: Implications for a Mechanism of Cytotoxicity [作者：Grandinetti, G; Ingle, NP; Reineke, TM,期刊：Molecular Pharmaceutics, 页码：1709-1719 , 文章类型： Article，,卷期：2011年8-5] Poly(ethylenimine) (PEI) and PEI-based systems have been widely studied for use as nucleic acid delivery vehicles. However, many of these vehicles display high cytotoxicity, rendering them unfit for therapeutic use. By e... On the Mechanism of Targeting of Phage Fusion Protein-Modified Nanocarriers: Only the Binding Peptide Sequence Matters [作者：Wang, T; Kulkarni, N; D'Souza, GGM; Petrenko, VA; Torchilin, VP,期刊：Molecular Pharmaceutics, 页码：1720-1728 , 文章类型： Article，,卷期：2011年8-5] The integration of pharmaceutical nanocarriers with phage display techniques is emerging as a new paradigm for targeted cancer nanomedicines. We explored the direct use of landscape phage fusion proteins for the self-ass... Differences in DNA Condensation and Release by Lysine and Arginine Homopeptides Govern Their DNA Delivery Efficiencies [作者：Mann, A; Thakur, G; Shukla, V; Singh, AK; Khanduri, R; Naik, R; Jiang, Y; Kalra, N; Dwarakanath, BS; Langel, U; Ganguli, M,期刊：Molecular Pharmaceutics, 页码：1729-1741 , 文章类型： Article，,卷期：2011年8-5] Designing of nanocarriers that can efficiently deliver therapeutic DNA payload and allow its smooth intracellular release for transgene expression is still a major constraint. The optimization of DNA nanocarriers require... Molecular Imaging of Intracellular Drug-Membrane Aggregate Formation [作者：Baik, J; Rosania, GR,期刊：Molecular Pharmaceutics, 页码：1742-1749 , 文章类型： Article，,卷期：2011年8-5] Clofazimine is a lipophilic antibiotic with an extremely long pharmacokinetic half-life associated with the appearance of crystal-like drug inclusions, in vivo. Here, we studied how clofazimine accumulates inside cells i... In Vivo Labeling of B16 Melanoma Tumor Xenograft with a Thiol-Reactive Gadolinium Based MRI Contrast Agent [作者：Menchise, V; Digilio, G; Gianolio, E; Cittadino, E; Catanzaro, V; Carrera, C; Aime, S,期刊：Molecular Pharmaceutics, 页码：1750-1756 , 文章类型： Article，,卷期：2011年8-5] Murine melanoma B16 cells display on the extracellular side of the plasma membrane a large number of reactive protein thiols (exofacial protein thiols, EPTs). These EPTs can be chemically labeled with Gd-DO3A-PDP, a Gd(I... Nuclear Inclusion of Nontargeted and Chromatin-Targeted Polystyrene Beads and Plasmid DNA Containing Nanoparticles [作者：Symens, N; Walczak, R; Demeester, J; Mattaj, I; De Smedt, SC; Remaut, K,期刊：Molecular Pharmaceutics, 页码：1757-1766 , 文章类型： Article，,卷期：2011年8-5] The nuclear membrane is one of the major cellular barriers in the delivery of plasmid DNA (pDNA). Cell division has a positive influence on the expression efficiency since, at the end of mitosis, pDNA or pDNA containing ... Sustained Release of Transgenic Human Factor IX: Preparation, Characterization, and in Vivo Efficacy [作者：Chang, LC; Yang, CY; Chua, ACN; Lin, YJ; Lai, SM,期刊：Molecular Pharmaceutics, 页码：1767-1774 , 文章类型： Article，,卷期：2011年8-5] The current regimen of factor IX (FIX) injection is of an episodic format, which leads to limited efficacy. A sustained release dosage form is beneficial in terms of reducing the injection frequency and improving the the... PET of Insulinoma Using (18)F-FBEM-EM3106B, a New GLP-1 Analogue [作者：Gao, HK; Niu, G; Yang, M; Quan, QM; Ma, Y; Murage, EN; Ahn, JM; Kiesewetter, DO; Chen, XY,期刊：Molecular Pharmaceutics, 页码：1775-1782 , 文章类型： Article，,卷期：2011年8-5] Derived from endocrine pancreatic beta cells, insulinomas express glucagon-like peptide-1 (GLP-1) receptor with high density and incidence. In this study, we labeled a novel GLP-1 analogue, EM3106B, with (18)F and perfor... Expression of MUC5AC in Ocular Surface Epithelial Cells Using Cationized Gelatin Nanoparticles [作者：Zorzi, GK; Contreras-Ruiz, L; Parraga, JE; Lopez-Garcia, A; Bello, RR; Diebold, Y; Seijo, B; Sanchez, A,期刊：Molecular Pharmaceutics, 页码：1783-1788 , 文章类型： Article，,卷期：2011年8-5] Decreased production of the mucin MUC5AC in the eye is related to several pathological conditions, including dry eye syndrome. A specific strategy for increasing the ocular levels of MUC5AC is not yet available. Using a ... The Involvement of Organic Anion Transporting Polypeptide in the Hepatic Uptake of Telmisartan in Rats: PET Studies with [(11)C]Telmisartan [作者：Takashima, T; Hashizume, Y; Katayama, Y; Murai, M; Wada, Y; Maeda, K; Sugiyama, Y; Watanabe, Y,期刊：Molecular Pharmaceutics, 页码：1789-1798 , 文章类型： Article，,卷期：2011年8-5] Telmisartan, a selective angiotensin II receptor antagonist, is primarily excreted via hepatobiliary transport. The predominant contribution of organic anion transporting polypeptide (OATP) 1B3 in its hepatic uptake of t... (18)F-Labeled Modified Porous Silicon Particles for Investigation of Drug Delivery Carrier Distribution in Vivo with Positron Emission Tomography [作者：Sarparanta, M; Makila, E; Heikkila, T; Salonen, J; Kukk, E; Lehto, VP; Santos, HA; Hirvonen, J; Airaksinen, AJ,期刊：Molecular Pharmaceutics, 页码：1799-1806 , 文章类型： Article，,卷期：2011年8-5] Because of its biocompatibility and ability to accommodate a variety of payloads from poorly soluble drugs to biomolecules, porous silicon (PSi) is a lucrative material for the development of carriers for particle-mediat...