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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共32条记录   Viruses in Pharmaceutical Research: Swiss Army Knives for the Prevention and Treatment of Disease [作者：Everts, M,期刊：Molecular Pharmaceutics, 页码：1-2 , 文章类型： Editorial Material，,卷期：2011年8-1] Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach [作者：Matthews, QL,期刊：Molecular Pharmaceutics, 页码：3-11 , 文章类型： Review，,卷期：2011年8-1] Some viral vectors are potent inducers of cellular and humoral responses; therefore, viral vectors can be used to vaccinate against cancer or infectious diseases. This report will locus on adenovirus (Ad)-based vectors. ... Oncolytic Adenoviruses for the Treatment of Human Cancer: Focus on Translational and Clinical Data [作者：Pesonen, S; Kangasniemi, L; Hemininki, A,期刊：Molecular Pharmaceutics, 页码：12-28 , 文章类型： Review，,卷期：2011年8-1] Although results of cancer treatment have improved steadily, metastatic solid tumors can be cured only rarely and therefore new modalities are needed. Tumors often become apoptosis-resistant and capable of excluding drug... The Art of Engineering Viral Nanoparticles [作者：Pokorski, JK; Steinmetz, NF,期刊：Molecular Pharmaceutics, 页码：29-43 , 文章类型： Review，,卷期：2011年8-1] Viral nanotechnology is an emerging and highly interdisciplinary field in which viral nanoparticles (VNPs) are applied in diverse areas such as electronics, energy and next-generation medical devices. VNPs have been deve... Strategies for the Rapid Construction of Conditionally-Replicating HSV-1 Vectors Expressing Foreign Genes as Anticancer Therapeutic Agents [作者：Parker, JN; Zheng, XJ; Luckett, W; Markert, JM; Cassady, KA,期刊：Molecular Pharmaceutics, 页码：44-49 , 文章类型： Review，,卷期：2011年8-1] Conditionally replication-competent Herpes Simplex Virus Type 1 (HSV-1) vectors expressing foreign genes have been developed as experimental therapeutic agents. Traditional methods of virus construction, including growth... Pharmacological Interventions for Improving Adenovirus Usage in Gene Therapy [作者：Haisma, HJ; Bellu, AR,期刊：Molecular Pharmaceutics, 页码：50-55 , 文章类型： Review，,卷期：2011年8-1] Gene therapy may be an innovative and promising new treatment strategy for cancer but is limited due to a low efficiency and specificity of gene delivery to the target cells. Adenovirus is the preferred gene therapy vect... Viruses in Pharmaceutical Research: Pulmonary Vascular Disease [作者：Reynolds, PN,期刊：Molecular Pharmaceutics, 页码：56-64 , 文章类型： Review，,卷期：2011年8-1] The management and understanding of pulmonary arterial hypertension (PAH) has undergone something of a revolution in the last 10 years, with new pharmacological agents entering routine clinical practice and significantly... Heterologous Prime-Boost Immunizations with a Virosomal and an Alphavirus Replicon Vaccine [作者：Walczak, M; de Mare, A; Riezebos-Brilman, A; Regts, J; Hoogeboom, BN; Visser, JT; Fiedler, M; Jansen-Durr, P; van der Zee, AGJ; Nijman, HW; Wilschut, J; Daemen, T,期刊：Molecular Pharmaceutics, 页码：65-77 , 文章类型： Article，,卷期：2011年8-1] Heterologous prime-boost immunization strategies in general establish higher frequencies of antigen-specific T lymphocytes than homologous prime-boost protocols or single immunizations. We developed virosomes and recombi... Species Differences in the Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus [作者：Wonganan, P; Clemens, CC; Brasky, K; Pastore, L; Croyle, MA,期刊：Molecular Pharmaceutics, 页码：78-92 , 文章类型： Article，,卷期：2011年8-1] Clinically relevant doses of helper-dependent adenoviruses (HDAds) provoke the host response against capsid proteins in primates and rodents. To determine if PEGylation truly affects this, baboons and mice were given eit... Safety of Glucocorticoids in Cancer Patients Treated with Oncolytic Adenoviruses [作者：Rajecki, M; Raki, M; Escutenaire, S; Pesonen, S; Cerullo, V; Helminen, A; Hannuksela, P; Partanen, K; Laasonen, L; Joensuu, T; Kangasniemi, L; Haavisto, E; Kanerva, A; Ahtiainen, L; Hemminki, A,期刊：Molecular Pharmaceutics, 页码：93-103 , 文章类型： Article，,卷期：2011年8-1] Oncolytic adenoviruses are an emerging treatment option for advanced and refractory cancer. Such patients are often treated with corticosteroids to ameliorate tumor associated symptoms. Thus, it is important to evaluate ... Targeting Nanosystems to Human DCs via Fc Receptor as an Effective Strategy to Deliver Antigen for Immunotherapy [作者：Cruz, LJ; Rueda, F; Cordobilla, B; Simon, L; Hosta, L; Albericio, F; Domingo, JC,期刊：Molecular Pharmaceutics, 页码：104-116 , 文章类型： Article，,卷期：2011年8-1] Dendritic cells (DCs) are increasingly being explored as cellular vaccines for tumor immunotherapy, since they provide an effective system of antigen presentation both in vitro and in vivo. An additional advantage of thi... Hypoxia-Mediated Down-Regulation of OCTN2 and PPAR alpha Expression in Human Placentas and in BeWo Cells [作者：Chang, TT; Shyu, MK; Huang, MC; Hsu, CC; Yeh, SY; Chen, MR; Lin, CJ,期刊：Molecular Pharmaceutics, 页码：117-125 , 文章类型： Article，,卷期：2011年8-1] The objective of the present study was to investigate the effects of hypoxia on placental expression of OCTN2 and PPAR alpha. OCTN2 and PPAR alpha expression in the human placenta in the presence or absence of preeclamps... Reducing the Background Fluorescence in Mice Receiving Fluorophore/Inhibitor DNA Duplexes [作者：Liang, MM; Liu, XR; Liu, GZ; Dou, SP; Cheng, DF; Liu, YX; Rusckowski, M; Hnatowich, DJ,期刊：Molecular Pharmaceutics, 页码：126-132 , 文章类型： Article，,卷期：2011年8-1] OCT2 and MATE1 Provide Bidirectional Agmatine Transport [作者：Winter, TN; Elmquist, WF; Fairbanks, CA,期刊：Molecular Pharmaceutics, 页码：133-142 , 文章类型： Article，,卷期：2011年8-1] Agmatine is a biogenic amine (L-arginine metabolite) of potential relevance to several central nervous system (CNS) conditions. The identities of transporters underlying agmatine and polyamine disposition in mammalian sy... Modulation of CD4+T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery [作者：Park, J; Gao, WD; Whiston, R; Strom, TB; Metcalfe, S; Fahmy, TM,期刊：Molecular Pharmaceutics, 页码：143-152 , 文章类型： Article，,卷期：2011年8-1] Within the immune system there is an exquisite ability to discriminate between "self" and "non-self' that is orchestrated by antigen-specific T lymphocytes. Genomic plasticity enables differentiation of naive CD4+ T lymp... Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3 beta[N ',N '-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses [作者：Henriksen-Lacey, M; Christensen, D; Bramwell, VW; Lindenstrom, T; Agger, EM; Andersen, P; Perrie, Y,期刊：Molecular Pharmaceutics, 页码：153-161 , 文章类型： Article，,卷期：2011年8-1] The immunostimulatory capacities of cationic liposomes are well-documented and are attributed both to inherent immunogenicity of the cationic lipid and more physical capacities such as the formation of antigen depots and...