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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Colon Cancer: An Update and Future Directions INTRODUCTION [作者：Yang, VW; Lewis, J; Wang, TC; Rustgi, AK,期刊：Gastroenterology, 页码：2027-2028 , 文章类型： Editorial Material，,卷期：2010年138-6] Primary Prevention of Colorectal Cancer [作者：Chan, AT; Giovannucci, EL,期刊：Gastroenterology, 页码：2029-U40 , 文章类型： Article，,卷期：2010年138-6] Colorectal cancer has been strongly associated with a Western lifestyle. In the past several decades, much has been learned about the dietary, lifestyle, and medication risk factors for this malignancy. Although there is... Hereditary and Familial Colon Cancer [作者：Jasperson, KW; Tuohy, TM; Neklason, DW; Burt, RW,期刊：Gastroenterology, 页码：2044-2058 , 文章类型： Article，,卷期：2010年138-6] Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis co... The Chromosomal Instability Pathway in Colon Cancer [作者：Pino, MS; Chung, DC,期刊：Gastroenterology, 页码：2059-2072 , 文章类型： Article，,卷期：2010年138-6] The acquisition of genomic instability is a crucial feature in tumor development and there are at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability (CIN), microsatellite instability... Microsatellite Instability in Colorectal Cancer [作者：Boland, CR; Goel, A,期刊：Gastroenterology, 页码：2073-U87 , 文章类型： Article，,卷期：2010年138-6] Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome ... Role of the Serrated Pathway in Colorectal Cancer Pathogenesis [作者：Leggett, B; Whitehall, V,期刊：Gastroenterology, 页码：2088-2100 , 文章类型： Article，,卷期：2010年138-6] The "serrated neoplastic pathway" describes the progression of serrated polyps, including sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The recognition of this pathway during the last... Inflammation and Colon Cancer [作者：Terzic, J; Grivennikov, S; Karin, E; Karin, M,期刊：Gastroenterology, 页码：2101-U119 , 文章类型： Article，,卷期：2010年138-6] The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowe... Progress and Challenges in Colorectal Cancer Screening and Surveillance [作者：Lieberman, D,期刊：Gastroenterology, 页码：2115-2126 , 文章类型： Article，,卷期：2010年138-6] Colorectal cancer is a leading cause of cancer death throughout the world. There is evidence that screening of average-risk individuals can result in mortality reduction with early cancer detection and cancer prevention ... Molecular Detection of Colorectal Neoplasia [作者：Ahlquist, DA,期刊：Gastroenterology, 页码：2127-2139 , 文章类型： Article，,卷期：2010年138-6] A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of mole... Advances in Endoscopic Imaging of Colorectal Neoplasia [作者：Wallace, MB; Kiesslich, R,期刊：Gastroenterology, 页码：2140-2150 , 文章类型： Article，,卷期：2010年138-6] Colon cancer screening is arguably the most important activity performed by gastroenterologists. Recent decreases in rates of death from colorectal cancer indicate that screening methods such as colonoscopy have a positi... Colon Cancer Stem Cells: Promise of Targeted Therapy [作者：Todaro, M; Francipane, MG; Medema, JP; Stassi, G,期刊：Gastroenterology, 页码：2151-2162 , 文章类型： Article，,卷期：2010年138-6] First developed for hematologic disorders, the concept of cancer stem cells (CSCs) was expanded to solid tumors, including colorectal cancer (CRC). The traditional model of colon carcinogenesis includes several steps tha... Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer [作者：Winder, T; Lenz, HJ,期刊：Gastroenterology, 页码：2163-2176 , 文章类型： Article，,卷期：2010年138-6] Treatment of colorectal cancer (CRC) has developed considerably over the past decade, especially in the areas of targeted therapeutics and biomarker development. Multiple cellular pathways influence the growth and metast... Colorectal Cancer: National and International Perspective on the Burden of Disease and Public Health Impact [作者：Gellad, ZF; Provenzale, D,期刊：Gastroenterology, 页码：2177-2190 , 文章类型： Article，,卷期：2010年138-6] Colorectal cancer is a significant cause of morbidity and mortality in the United States and throughout the world. The importance of this disease to gastroenterologists cannot be understated, given that screening and sur...