- Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease
[作者:Patel, S; Player, MR,期刊:Current Topics in Medicinal Chemistry, 页码:599-610 , 文章类型: Review,,卷期:2009年9-7]
- FMS is the exclusive receptor tyrosine kinase for colony-stimulating factor-1 (CSF-1, also known as M-CSF), which regulates the survival, proliferation, differentiation, and function of macrophage lineage cells. Since CS...
- Progress Towards the Development of Anti-Inflammatory Inhibitors of IKK beta
[作者:Bamborough, P; Callahan, JF; Christopher, JA; Kerns, JK; Liddle, J; Miller, DD; Morse, MA; Rumsey, WL; Williamson, R,期刊:Current Topics in Medicinal Chemistry, 页码:623-639 , 文章类型: Review,,卷期:2009年9-7]
- The I B kinases (IKKs) are essential components of the signaling pathway by which the NF-kappa B p50/RelA transcription factor is activated in response to pro-inflammatory stimuli such as lipopolysaccharide (LPS) and tum...
- Successful Structure-Based Design of Recent p38 MAP Kinase Inhibitors
[作者:Karcher, SC; Laufer, SA,期刊:Current Topics in Medicinal Chemistry, 页码:655-676 , 文章类型: Review,,卷期:2009年9-7]
- Inflammation is a complex immune response to cellular and tissue damage caused by physical, chemical, immunological, or microbial stimuli [1]. Prior to the successful launch of the anti-cytokine biologics [2-4], therapeu...
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