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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共59条记录   Rapid creation of Arabidopsis doubled haploid lines for quantitative trait locus mapping [作者：Seymour, DK; Filiault, DL; Henry, IM; Monson-Miller, J; Ravi, M; Pang, AD; Comai, L; Chan, SWL; Maloof, JN,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4227-4232 , 文章类型： Article，,卷期：2012年109-11] Quantitative trait loci (QTL) mapping is a powerful tool for investigating the genetic basis of natural variation. QTL can be mapped using a number of different population designs, but recombinant inbred lines (RILs) are... Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A [作者：Chaudhuri, AA; So, AYL; Mehta, A; Minisandram, A; Sinha, N; Jonsson, VD; Rao, DS; O'Connell, RM; Baltimore, D,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4233-4238 , 文章类型： Article，,卷期：2012年109-11] MicroRNA-125b (miR-125b) is up-regulated in patients with leukemia. Overexpression of miR-125b alone in mice causes a very aggressive, transplantable myeloid leukemia. Before leukemia, these mice do not display elevation... Systematic identification of type I and type II interferon-induced antiviral factors [作者：Liu, SY; Sanchez, DJ; Aliyari, R; Lu, S; Cheng, GH,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4239-4244 , 文章类型： Article，,卷期：2012年109-11] Type I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by... Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials [作者：Pedraza, E; Coronel, MM; Fraker, CA; Ricordi, C; Stabler, CL,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4245-4250 , 文章类型： Article，,卷期：2012年109-11] A major hindrance in engineering tissues containing highly metabolically active cells is the insufficient oxygenation of these implants, which results in dying or dysfunctional cells in portions of the graft. The develop... Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma [作者：Lin, L; Bass, AJ; Lockwood, WW; Wang, ZW; Silvers, AL; Thomas, DG; Chang, AC; Lin, J; Orringer, MB; Li, WQ; Glover, TW; Giordano, TJ; Lam, WL; Meyerson, M; Beer, DG,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4251-4256 , 文章类型： Article，,卷期：2012年109-11] Gene amplification is a tumor-specific event during malignant transformation. Recent studies have proposed a lineage-dependency (addiction) model of human cancer whereby amplification of certain lineage transcription fac... Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature [作者：Serra-Nedelec, AD; Edouard, T; Treguer, K; Tajan, M; Araki, T; Dance, M; Mus, M; Montagner, A; Tauber, M; Salles, JP; Valet, P; Neel, BG; Raynal, P; Yart, A,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4257-4262 , 文章类型： Article，,卷期：2012年109-11] Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 (PTPN11), is characterized by congenital cardiopathies, facial dysmorphic features, and short statu... Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis [作者：Hirose, Y; Saijou, E; Sugano, Y; Takeshita, F; Nishimura, S; Nonaka, H; Chen, YR; Sekine, K; Kido, T; Nakamura, T; Kato, S; Kanke, T; Nakamura, K; Nagai, R; Ochiya, T; Miyajima, A,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4263-4268 , 文章类型： Article，,卷期：2012年109-11] Hyaluronic acid (HA) has been implicated in the proliferation and metastasis of tumor cells. However, most previous studies were conducted on extracellular matrix or pericellular HA, and the role of circulating HA in viv... A distinct lineage of influenza A virus from bats [作者：Tong, SX; Li, Y; Rivailler, P; Conrardy, C; Castillo, DAA; Chen, LM; Recuenco, S; Ellison, JA; Davis, CT; York, IA; Turmelle, AS; Moran, D; Rogers, S; Shi, M; Tao, Y; Weil, MR; Tang, K; Rowe, LA; Sammons, S; Xu, XY; Frace, M; Lindblade, KA; Cox, NJ; Anderson, LJ; Rupprecht, CE; Donis, RO,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4269-4274 , 文章类型： Article，,卷期：2012年109-11] Influenza A virus reservoirs in animals have provided novel genetic elements leading to the emergence of global pandemics in humans. Most influenza A viruses circulate in waterfowl, but those that infect mammalian hosts ... Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography [作者：Bharat, TAM; Noda, T; Riches, JD; Kraehling, V; Kolesnikova, L; Becker, S; Kawaoka, Y; Briggs, JAG,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4275-4280 , 文章类型： Article，,卷期：2012年109-11] Ebola virus is a highly pathogenic filovirus causing severe hemorrhagic fever with high mortality rates. It assembles heterogenous, filamentous, enveloped virus particles containing a negative-sense, single-stranded RNA ... Honesty mediates the relationship between serotonin and reaction to unfairness [作者：Takahashi, H; Takano, H; Camerer, CF; Ideno, T; Okubo, S; Matsui, H; Tamari, Y; Takemura, K; Arakawa, R; Kodaka, F; Yamada, M; Eguchi, Y; Murai, T; Okubo, Y; Kato, M; Ito, H; Suhara, T,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4281-4284 , 文章类型： Article，,卷期：2012年109-11] How does one deal with unfair behaviors? This subject has long been investigated by various disciplines including philosophy, psychology, economics, and biology. However, our reactions to unfairness differ from one indiv... Adaptive coding of reward prediction errors is gated by striatal coupling [作者：Park, SQ; Kahnt, T; Talmi, D; Rieskamp, J; Dolan, RJ; Heekeren, HR,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4285-4289 , 文章类型： Article，,卷期：2012年109-11] To efficiently represent all of the possible rewards in the world, dopaminergic midbrain neurons dynamically adapt their coding range to the momentarily available rewards. Specifically, these neurons increase their activ... Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network [作者：Li, Y; Aimone, JB; Xu, XM; Callaway, EM; Gage, FH,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4290-4295 , 文章类型： Article，,卷期：2012年109-11] New neurons are continuously generated in the dentate gyrus (DG) in the adult hippocampus, and new granule cells (GCs) have been shown to be necessary for several aspects of learning and memory. Nonetheless, the limited ... Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis [作者：Marinkovic, P; Reuter, MS; Brill, MS; Godinho, L; Kerschensteiner, M; Misgeld, T,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4296-4301 , 文章类型： Article，,卷期：2012年109-11] Axonal transport deficits have been reported in many neurodegenerative conditions and are widely assumed to be an immediate causative step of axon and synapse loss. By imaging changes in axonal morphology and organelle t... Orientation selectivity and noise correlation in awake monkey area V1 are modulated by the gamma cycle [作者：Womelsdorf, T; Lima, B; Vinck, M; Oostenveld, R; Singer, W; Neuenschwander, S; Fries, P,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4302-4307 , 文章类型： Article，,卷期：2012年109-11] Gamma-band synchronization adjusts the timing of excitatory and inhibitory inputs to a neuron. Neurons in the visual cortex are selective for stimulus orientation because of dynamic interactions between excitatory and in... Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor [作者：Lipovsek, M; Im, GJ; Franchini, LF; Pisciottano, F; Katz, E; Fuchs, PA; Elgoyhen, AB,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4308-4313 , 文章类型： Article，,卷期：2012年109-11] The alpha 9 and alpha 10 cholinergic nicotinic receptor subunits assemble to form the receptor that mediates efferent inhibition of hair cell function within the auditory sensory organ, a mechanism thought to modulate th... Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function [作者：Beigi, F; Gonzalez, DR; Minhas, KM; Sun, QA; Foster, MW; Khan, SA; Treuer, AV; Dulce, RA; Harrison, RW; Saraiva, RM; Premer, C; Schulman, IH; Stamler, JS; Hare, JM,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4314-4319 , 文章类型： Article，,卷期：2012年109-11] Although protein S-nitrosylation is increasingly recognized as mediating nitric oxide (NO) signaling, roles for protein denitrosylation in physiology remain unknown. Here, we show that S-nitrosoglutathione reductase (GSN...