- Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
[作者:Li, XN; Song, J; Zhang, L; LeMaire, SA; Hou, XY; Zhang, C; Coselli, JS; Chen, L; Wang, XL; Zhang, Y; Shen, YH,期刊:Diabetes, 页码:2246-2257 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Oxidative stress induced by free fatty acids contributes to the development of cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may attenuate these pathogenic processes. Ac...
- Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
[作者:Hilbrands, R; Huurman, VAL; Gillard, P; Velthuis, JHL; De Waele, M; Mathieu, C; Kaufman, L; Pipeleers-Marichal, M; Ling, ZD; Movahedi, B; Jacobs-Tulleneers-Thevissen, D; Monbaliu, D; Ysebaert, D; Gorus, FK; Roep, BO; Pipeleers, DG; Keymeulen, B,期刊:Diabetes, 页码:2267-2276 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-The metabolic outcome of islet cell transplants in type 1 diabetic patients is variable. This retrospective analysis examines whether differences in recipient characteristics at the time of transplantation are ...
- Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
[作者:Pocai, A; Carrington, PE; Adams, JR; Wright, M; Eiermann, G; Zhu, L; Du, XB; Petrov, A; Lassman, ME; Jiang, GQ; Liu, F; Miller, C; Tota, LM; Zhou, GC; Zhang, XP; Sountis, MM; Santoprete, A; Capito, E; Chicchi, GG; Thornberry, N; Bianchi, E; Pessi, A; Marsh, DJ; SinhaRoy, R,期刊:Diabetes, 页码:2258-2266 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide that reduces body weight in obese subjects through increased energy expenditure and decrea...
- Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit A Mechanism of Accelerated beta-Cell Failure in Fulminant Type 1 Diabetes
[作者:Tanaka, S; Nishida, Y; Aida, K; Maruyama, T; Shimada, A; Suzuki, M; Shimura, H; Takizawa, S; Takahashi, M; Akiyama, D; Arai-Yamashita, S; Furuya, F; Kawaguchi, A; Kaneshige, M; Katoh, R; Endo, T; Kobayashi, T,期刊:Diabetes, 页码:2285-2291 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Fulminant type 1 diabetes is characterized by the rapid onset of severe hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetes complications. Causative mechanisms for accelerated beta-cell f...
- Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice
[作者:Parker, MJ; Xue, S; Alexander, JJ; Wasserfall, CH; Campbell-Thompson, ML; Battaglia, M; Gregori, S; Mathews, CE; Song, SH; Troutt, M; Eisenbeis, S; Williams, J; Schatz, DA; Haller, MJ; Atkinson, MA,期刊:Diabetes, 页码:2277-2284 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-The autoimmune destruction of beta-cells in type 1 diabetes results in a loss of insulin production and glucose homeostasis. As such, an immense interest exists for the development of therapies capable of atten...
- Mitochondrial Networking Protects beta-Cells From Nutrient-Induced Apoptosis
[作者:Molina, AJA; Wikstrom, JD; Stiles, L; Las, G; Mohamed, H; Elorza, A; Walzer, G; Twig, G; Katz, S; Corkey, BE; Shirihai, OS,期刊:Diabetes, 页码:2303-2315 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Previous studies have reported that beta-cell mitochondria exist as discrete organelles that exhibit heterogeneous bioenergetic capacity. To date, networking activity, and its role in mediating beta-cell mitoch...
- Importance of Extranuclear Estrogen Receptor-alpha and Membrane G Protein-Coupled Estrogen Receptor in Pancreatic Islet Survival
[作者:Liu, SH; Le May, C; Wong, WPS; Ward, RD; Clegg, DJ; Marcelli, M; Korach, KS; Mauvais-Jarvis, F,期刊:Diabetes, 页码:2292-2302 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-We showed that 17 beta-estradiol (E-2) favors pancreatic beta-cell survival via the estrogen receptor-alpha (ER alpha) in mice. E-2 activates nuclear estrogen receptors via an estrogen response element (ERE). E...
- Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic beta- or alpha-Cells In Vivo
[作者:Ueberberg, S; Meier, JJ; Waengler, C; Schechinger, W; Dietrich, JW; Tannapfel, A; Schmitz, I; Schirrmacher, R; Koller, M; Klein, HH; Schneider, S,期刊:Diabetes, 页码:2324-2334 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Noninvasive determination of pancreatic beta-cell mass in vivo has been hampered by the lack of suitable beta-cell-specific imaging agents. This report outlines an approach for the development of novel ligands ...
- Islet beta-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli
[作者:Carrington, EM; McKenzie, MD; Jansen, E; Myers, M; Fynch, S; Kos, C; Strasser, A; Kay, TW; Scott, CL; Allison, J,期刊:Diabetes, 页码:2316-2323 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Bcl-xL is an antiapoptotic member of the Bcl-2 family of proteins and a potent regulator of cell death. We investigated the importance of Bcl-xL for beta-cells by deleting the Bcl-x gene specifically in beta-ce...
- Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells
[作者:Tanaka, J; Qiang, L; Banks, AS; Welch, CL; Matsumoto, M; Kitamura, T; Ido-Kitamura, Y; DePinho, RA; Accili, D,期刊:Diabetes, 页码:2344-2354 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) ...
- Functional Brain Connectivity and Neurocognitive Functioning in Patients With Long-Standing Type 1 Diabetes With and Without Microvascular Complications A Magnetoencephalography Study
[作者:van Duinkerken, E; Klein, M; Schoonenboom, NSM; Hoogma, RPLM; Moll, AC; Snoek, FJ; Stam, CJ; Diamant, M,期刊:Diabetes, 页码:2335-2343 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Hyperglycemia-associated microvascular disease may underlie changes in cerebral functioning and cognitive performance in patients with type 1 diabetes. Functional connectivity, an indicator of functional intera...
- Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy
[作者:Nasu, T; Maeshima, Y; Kinomura, M; Hirokoshi-Kawahara, K; Tanabe, K; Sugiyama, H; Sonoda, H; Sato, Y; Makino, H,期刊:Diabetes, 页码:2365-2375 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-The involvement of proangiogenic factors such as vascular endothelial growth factor as well as the therapeutic efficacy of angiogenesis inhibitors in early diabetic nephropathy has been reported. Vasohibin-1 (V...
- Selective Inhibition of Protein Kinase C beta(2) Attenuates Inducible Nitric Oxide Synthase-Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats
[作者:Nagareddy, PR; Soliman, H; Lin, GR; Rajput, PS; Kumar, U; McNeill, JH; MacLeod, KM,期刊:Diabetes, 页码:2355-2364 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Impaired cardiovascular function in diabetes is partially attributed to pathological overexpression of inducible nitric oxide synthase (iNOS) in cardiovascular tissues. We examined whether the hyperglycemia-ind...
- Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia
[作者:Shen, E; Li, YW; Li, Y; Shan, LM; Zhu, HQ; Feng, QP; Arnold, JMO; Peng, TQ,期刊:Diabetes, 页码:2386-2395 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Hyperglycemia induces reactive oxygen species (ROS) and apoptosis in cardiomyocytes, which contributes to diabetic cardiomyopathy. The present study was to investigate the role of Rac1 in ROS production and car...
- Dyslipidemia-Induced Neuropathy in Mice The Role of oxLDL/LOX-1
[作者:Vincent, AM; Hayes, JM; McLean, LL; Vivekanandan-Giri, A; Pennathur, S; Feldman, EL,期刊:Diabetes, 页码:2376-2385 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Neuropathy is a frequent and severe complication of diabetes. Multiple metabolic defects in type 2 diabetic patients result in oxidative injury of dorsal root ganglia (DRG) neurons. Our previous work focused on...
- Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
[作者:Grunnet, LG; Nilsson, E; Ling, C; Hansen, T; Pedersen, O; Groop, L; Vaag, A; Poulsen, P,期刊:Diabetes, 页码:2402-2408 , 文章类型: Article,,卷期:2009年58-10]
- OBJECTIVE-Common variants in FTO (the fat mass- and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We inves...
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