- m.3243A > G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive beta-Cell Dysfunction
[作者：Lindroos, MM; Majamaa, K; Tura, A; Mari, A; Kalliokoski, KK; Taittonen, MT; Iozzo, P; Nuutila, P,期刊：Diabetes, 页码：543-549 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-To study insulin sensitivity and perfusion in skeletal muscle together with the beta-cell function in subjects with the m.3243A>G mutation in mitochondrial DNA, the most common cause of mitochondrial diabetes. ...
- Maternal Low-Protein Diet or Hypercholesterolemia Reduces Circulating Essential Amino Acids and Leads to Intrauterine Growth Restriction
[作者：Bhasin, KKS; van Nas, A; Martin, LJ; Davis, RC; Devaskar, SU; Lusis, AJ,期刊：Diabetes, 页码：559-566 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-We have examined maternal mechanisms for adult,onset glucose intolerance, increased adiposity, and atherosclerosis using two mouse models for intrauterine growth restriction (IUGR): maternal protein restriction...
- Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion
[作者：Leloup, C; Tourrel-Cuzin, C; Magnan, C; Karaca, M; Castel, J; Carneiro, L; Colombani, AL; Ktorza, A; Casteilla, L; Penicaud, L,期刊：Diabetes, 页码：673-681 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Insulin secretion involves complex events in which the mitochondria play a pivotal role in the generation of signals that couple glucose detection to insulin secretion. Studies on the mitochondrial generation o...
- Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator-Activated Receptor (PPAR)-delta and Is of Metabolic Relevance in Humans
[作者：Staiger, H; Haas, C; Machann, J; Werner, R; Weisser, M; Schick, F; Machicao, F; Stefan, N; Fritsche, A; Haring, HU,期刊：Diabetes, 页码：579-589 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes). RESEARCH...
- Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance
[作者：Bruce, CR; Hoy, AJ; Turner, N; Watt, MJ; Allen, TL; Carpenter, K; Cooney, GJ; Febbraio, MA; Kraegen, EW,期刊：Diabetes, 页码：550-558 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Skeletal muscle insulin resistance is associated with lipid accumulation, but whether insulin resistance is due to reduced or enhanced flux of long-chain fatty acids into the mitochondria is both controversial ...
- Perinatal Risk Factors for Diabetes in Later Life
[作者：Kaijser, M; Bonamy, AKE; Akre, O; Cnattingius, S; Granath, F; Norman, M; Ekbom, A,期刊：Diabetes, 页码：523-526 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Low birth weight is consistently associated with an increased risk of type 2 diabetes in adulthood, but the individual contributions from poor fetal growth and preterm birth are not known. We therefore investig...
- Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/beta-Catenin Signaling Network
[作者：Lagathu, C; Christodoulides, C; Virtue, S; Cawthorn, WP; Franzin, C; Kimber, WA; Nora, ED; Campbell, M; Medina-Gomez, G; Cheyette, BNR; Vidal-Puig, AJ; Sethi, JK,期刊：Diabetes, 页码：609-619 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Wnt signaling inhibits adipogenesis, but its regulation, physiological relevance, and molecular effectors are poorly understood. Here, we identify the Writ modulator Dapper1/Frodo1 (Dact1) as a new preadipocyte...
- Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation
[作者：Kim, SJ; Nian, C; Doudet, DJ; McIntosh, CHS,期刊：Diabetes, 页码：641-651 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-The endopeptidase dipeptidyl peptidase-IV (DPP-IV) has been shown to NH2-terminally truncate incretin hormones, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1, thus ablating their abi...
- Protein Kinase A Regulatory Subunits in Human Adipose Tissue Decreased R2B Expression and Activity in Adipocytes From Obese Subjects
[作者：Mantovani, G; Bondioni, S; Alberti, L; Gilardini, L; Invitti, C; Corbetta, S; Zappa, MA; Ferrero, S; Lania, AG; Bosari, S; Beck-Peccoz, P; Spada, A,期刊：Diabetes, 页码：620-626 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-In human adipocytes, the cAMP-dependent pathway mediates signals originating from P-adrenergic activation, thus playing a key role in the regulation of important metabolic processes, i.e., lipolysis and thermog...
- Effects of Intensive Therapy and Antecedent Hypoglycemia on Counterregulatory Responses to Hypoglycemia in Type 2 Diabetes
[作者：Davis, SN; Mann, S; Briscoe, VJ; Ertl, AC; Tate, DB,期刊：Diabetes, 页码：701-709 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-The physiology of counterregulatory responses during hypoglycemia in intensively treated type 2 diabetic subjects is largely unknown. Therefore, the specific aims of the study tested the hypothesis that 1) 6 mo...
- Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss
[作者：Gregor, MF; Yang, L; Fabbrini, E; Mohammed, BS; Eagon, JC; Hotamisligil, GS; Klein, S,期刊：Diabetes, 页码：693-700 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent. studies in rodent models revealed endoplasmic reticulum (ER) str...
- Reduced Adipose Tissue Oxygenation in Human Obesity Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response
[作者：Pasarica, M; Sereda, OR; Redman, LM; Albarado, DC; Hymel, DT; Roan, LE; Rood, JC; Burk, DH; Smith, SR,期刊：Diabetes, 页码：718-725 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Based on rodent studies, we examined the hypothesis that increased adipose tissue (AT) mass in obesity without an adequate support of vascularization might lead to hypoxia, macrophage infiltration, and inflamma...
- Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
[作者：Putnam, AL; Brusko, TM; Lee, MR; Liu, WH; Szot, GL; Ghosh, T; Atkinson, MA; Bluestone, JA,期刊：Diabetes, 页码：652-662 , 文章类型： Article，,卷期：2009年58-3]
- OBJECTIVE-Regulatory T-cells (Tregs) have catalyzed the field of immune regulation. However, translating Treg-based therapies from animal models of autoimmunity to human clinical trials requires robust methods for the is...
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