- Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver
[作者：Zheng, D; Ionut, V; Mooradian, V; Stefanovski, D; Bergman, RN,期刊：Diabetes, 页码：352-359 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Recent progress suggests that exenatide, a mimetic of glucagon-like peptide-1 (GLP-1), might lower glycemia independent of increased beta-cell response or reduced gastrointestinal motility. We aimed to investig...
- Enhanced Expression of Janus Kinase-Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
[作者：Berthier, CC; Zhang, H; Schin, M; Henger, A; Nelson, RG; Yee, B; Boucherot, A; Neusser, MA; Cohen, CD; Carter-Su, C; Argetsinger, LS; Rastaldi, MP; Brosius, FC; Kretzler, M,期刊：Diabetes, 页码：469-477 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Glomerular mesangial expansion and podocyte loss are important early features of diabetic nephropathy, whereas tubulointerstitial injury and fibrosis are critical for progression of diabetic nephropathy to kidn...
- Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data
[作者：Timpson, NJ; Lindgren, CM; Weedon, MN; Randall, J; Ouwehand, WH; Strachan, DP; Rayner, NW; Walker, M; Hitman, GA; Doney, ASF; Palmer, CNA; Morris, AD; Hattersley, AT; Zeggini, E; Frayling, TM; McCarthy, MI,期刊：Diabetes, 页码：505-510 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological het...
- Recognition of Human Proinsulin Leader Sequence by Class I-Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes
[作者：Toma, A; Laika, T; Haddouk, S; Luce, S; Briand, JP; Camoin, L; Connan, F; Lambert, M; Caillat-Zucman, S; Carel, JC; Muller, S; Choppin, J; Lemonnier, F; Boitard, C,期刊：Diabetes, 页码：394-402 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-A restricted region of proinsulin located in the B chain and adjacent region of C-peptide has been shown to contain numerous candidate epitopes recognized by CD8(+) T-cells. Our objective is to characterize HLA...
- Site-Specific GlcNAcylation of Human Erythrocyte Proteins Potential Biomarker(s) for Diabetes
[作者：Wang, Z; Park, K; Comer, F; Hsieh-Wilson, LC; Saudek, CD; Hart, GW,期刊：Diabetes, 页码：309-317 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-O-linked N-acetylglucosamine (O-GlcNAc) is upregulated in diabetic tissues and plays a role in insulin resistance and glucose toxicity. Here, we investigated the extent of GlcNAcylation on human erythrocyte pro...
- Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
[作者：Hauge-Evans, AC; King, AJ; Carmignac, D; Richardson, CC; Robinson, ICAF; Low, MJ; Christie, MR; Persaud, SJ; Jones, PM,期刊：Diabetes, 页码：403-411 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion...
- Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function Implications for Rigorous Glycemic Control
[作者：Adler, GK; Bonyhay, I; Fainng, H; Waring, E; Dotson, S; Freeman, R,期刊：Diabetes, 页码：360-366 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Glycemic control decreases the incidence and progression of diabetic complications but increases the incidence of hypoglycemia. Hypoglycemia can impair hormonal and autonomic responses to subsequent hypoglycemi...
- Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking
[作者：Bergouignan, A; Trudel, G; Simon, C; Chopard, A; Schoeller, DA; Momken, I; Votruba, SB; Desage, M; Burdge, GC; Gauquelin-Koch, G; Normand, S; Blanc, S,期刊：Diabetes, 页码：367-376 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Obesity and diabetes are characterized by the incapacity to use fat as fuel. We hypothesized that this reduced fat oxidation is secondary to a sedentary lifestyle.RESEARCH DESIGN AND METHODS-We investigated the...
- Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease
[作者：Martin, B; Golden, E; Carlson, OD; Pistell, P; Zhou, J; Kim, W; Frank, BP; Thomas, S; Chadwick, WA; Greig, NH; Bate, GP; Sathasivam, K; Bernier, M; Maudsley, S; Mattson, MP; Egan, JM,期刊：Diabetes, 页码：318-328 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-The aim of this study was to find an effective treatment for the genetic form of diabetes that is present in some Huntington's disease patients and in Huntington's disease mouse models. Huntington's disease is ...
- Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice
[作者：Han, MS; Chung, KW; Cheon, HG; Dal Rhee, S; Yoon, CH; Lee, MK; Kim, KW; Lee, MS,期刊：Diabetes, 页码：329-336 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Imatinib has been reported to induce regression of type 2 diabetes in chronic leukemia patients. However, the mechanism of diabetes amelioration by imatinib is unknown, and it is uncertain whether imatinib has ...
- DOC2B: A Novel Syntaxin-4 Binding Protein Mediating Insulin-Regulated GLUT4 Vesicle Fusion in Adipocytes
[作者：Fukuda, N; Emoto, M; Nakamori, Y; Taguchi, A; Miyamoto, S; Uraki, S; Oka, Y; Tanizawa, Y,期刊：Diabetes, 页码：377-384 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Insulin stimulates glucose uptake in skeletal muscle and adipose tissues primarily by stimulating the translocation of vesicles containing a facilitative glucose transporter, GLUT4, from intracellular compartme...
- Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+](c) by Different Mechanisms in Isolated Mouse alpha-Cells
[作者：Quoix, N; Cheng-Xue, R; Mattart, L; Zeinoun, Z; Gniot, Y; Beauvois, MC; Henquin, JC; Gilon, P,期刊：Diabetes, 页码：412-421 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-We studied how glucose and ATP-sensitive K+ (K-ATP) channel modulators affect alpha-cell [Ca2+](c).RESEARCH DESIGN AND METHODS-GYY mice (expressing enhanced yellow fluorescent protein in alpha-cells) and NMRI m...
- Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance
[作者：Haus, JM; Kashyap, SR; Kasumov, T; Zhang, RL; Kelly, KR; DeFronzo, RA; Kirwan, JP,期刊：Diabetes, 页码：337-343 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-To quantitate plasma ceramide subspecies concentrations in obese subjects with type 2 diabetes and relate these plasma levels to the severity of insulin resistance. Ceramides are a putative mediator of insulin ...
- Overexpression of SIRT1 Protects Pancreatic beta-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-kappa B Signaling Pathway
[作者：Lee, JH; Song, MY; Song, EK; Kim, EK; Moon, WS; Han, MK; Park, JW; Kwon, KB; Park, BH,期刊：Diabetes, 页码：344-351 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-kappa B (NF-kappa B) signaling pathway and thereby has an anti-inflammatory function. Because of the central role of...
- Macrophage Content in Subcutaneous Adipose Tissue Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians
[作者：de Victoria, EOM; Xu, XY; Koska, J; Francisco, AM; Scalise, M; Ferrante, AW; Krakoff, J,期刊：Diabetes, 页码：385-393 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-In severely obese individuals and patients with diabetes, accumulation and activation of macrophages in adipose tissue has been implicated in the development of obesity-associated complications, including insul...
- Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and beta-Cell Death
[作者：Luciarti, DS; Gwiazda, KS; Yang, TLB; Kalynyak, TB; Bychkivska, Y; Frey, MHZ; Jeffrey, KD; Sampaio, AV; Underhill, TM; Johnson, JD,期刊：Diabetes, 页码：422-432 , 文章类型： Article，,卷期：2009年58-2]
- OBJECTIVE-Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca2+ release channels in the ER stress-associated apoptosis pathway remain unknown. Here, we e...
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