- The Flexible Motif V of Epstein-Barr Virus Deoxyuridine 5 '-Triphosphate Pyrophosphatase Is Essential for Catalysis
[作者:Freeman, L; Buisson, M; Tarbouriech, N; Van der Heyden, A; Labbe, P; Burmeister, WP,期刊:Journal of Biological Chemistry, 页码:25280-25289 , 文章类型: Article,,卷期:2009年284-37]
- Deoxyuridine 5'-triphosphate pyrophosphatases (dUTPases) are ubiquitous enzymes essential for hydrolysis of dUTP, thus preventing its incorporation into DNA. Although Epstein-Barr virus (EBV) dUTPase is monomeric, it has...
- HER2 Carboxyl-terminal Fragments Regulate Cell Migration and Cortactin Phosphorylation
[作者:Garcia-Castillo, J; Pedersen, K; Angelini, PD; Bech-Serra, JJ; Colome, N; Cunningham, MP; Parra-Palau, JL; Canals, F; Baselga, J; Arribas, J,期刊:Journal of Biological Chemistry, 页码:25302-25313 , 文章类型: Article,,卷期:2009年284-37]
- A group of breast cancer patients with a higher probability of developing metastasis expresses a series of carboxyl-terminal fragments (CTFs) of the tyrosine kinase receptor HER2. One of these fragments, 611-CTF, is a hy...
- A Conserved Na+ Binding Site of the Sodium-coupled Neutral Amino Acid Transporter 2 (SNAT2)
[作者:Zhang, Z; Albers, T; Fiumera, HL; Gameiro, A; Grewer, C,期刊:Journal of Biological Chemistry, 页码:25314-25323 , 文章类型: Article,,卷期:2009年284-37]
- The SLC38 family of solute transporters mediates the coupled transport of amino acids and Na+ into or out of cells. The structural basis for this coupled transport process is not known. Here, a profile-based sequence ana...
- Solution Structure of Human Pex5.Pex14.PTS1 Protein Complexes Obtained by Small Angle X-ray Scattering
[作者:Shiozawa, K; Konarev, PV; Neufeld, C; Wilmanns, M; Svergun, DI,期刊:Journal of Biological Chemistry, 页码:25334-25342 , 文章类型: Article,,卷期:2009年284-37]
- The Pex5p receptor recognizes newly synthesized peroxisomal matrix proteins which have a C-terminal peroxisomal targeting signal to the peroxisome. After docking to protein complexes on the membrane, these proteins are t...
- Quality Control of Photosystem II THYLAKOID UNSTACKING IS NECESSARY TO AVOID FURTHER DAMAGE TO THE D1 PROTEIN AND TO FACILITATE D1 DEGRADATION UNDER LIGHT STRESS IN SPINACH THYLAKOIDS
[作者:Khatoon, M; Inagawa, K; Pospisil, P; Yamashita, A; Yoshioka, M; Lundin, B; Horie, J; Morita, N; Jajoo, A; Yamamoto, Y; Yamamoto, Y,期刊:Journal of Biological Chemistry, 页码:25343-25352 , 文章类型: Article,,卷期:2009年284-37]
- Photosystem II is vulnerable to light damage. The reaction center-binding D1 protein is impaired during excessive illumination and is degraded and removed from photosystem II. Using isolated spinach thylakoids, we invest...
- A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role
[作者:Bullen, HE; Tonkin, CJ; O'Donnell, RA; Tham, WH; Papenfuss, AT; Gould, S; Cowman, AF; Crabb, BS; Gilson, PR,期刊:Journal of Biological Chemistry, 页码:25353-25363 , 文章类型: Article,,卷期:2009年284-37]
- The phylum Apicomplexa are a group of obligate intracellular parasites responsible for a wide range of important diseases. Central to the lifecycle of these unicellular parasites is their ability to migrate through anima...
- Structure and Function of the Two Tandem WW Domains of the Pre-mRNA Splicing Factor FBP21 (Formin-binding Protein 21)
[作者:Huang, XJ; Beullens, M; Zhang, JH; Zhou, Y; Nicolaescu, E; Lesage, B; Hu, Q; Wu, JH; Bollen, M; Shi, YY,期刊:Journal of Biological Chemistry, 页码:25375-25387 , 文章类型: Article,,卷期:2009年284-37]
- Human FBP21 (formin-binding protein 21) contains a matrin-type zinc finger and two tandem WW domains. It is a component of the spliceosomes and interacts with several established splicing factors. Here we demonstrate for...
- Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin
[作者:Zakrzewska, M; Wiedlocha, A; Szlachcic, A; Krowarsch, D; Otlewski, J; Olsnes, S,期刊:Journal of Biological Chemistry, 页码:25388-25403 , 文章类型: Article,,卷期:2009年284-37]
- Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological. Binding to heparin increases the stability of FGF1 and is bel...
- An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4
[作者:Motshwene, PG; Moncrieffe, MC; Grossmann, JG; Kao, C; Ayaluru, M; Sandercock, AM; Robinson, CV; Latz, E; Gay, NJ,期刊:Journal of Biological Chemistry, 页码:25404-25411 , 文章类型: Article,,卷期:2009年284-37]
- Toll-like receptors (TLRs) mediate responses to pathogen-associated molecules as part of the vertebrate innate immune response to infection. Receptor dimerization is coupled to downstream signal transduction by the recru...
- Dendritic mRNA Targeting of Jacob and N-Methyl-D-aspartate-induced Nuclear Translocation after Calpain-mediated Proteolysis
[作者:Kindler, S; Dieterich, DC; Schutt, J; Sahin, J; Karpova, A; Mikhaylova, M; Schob, C; Gundelfinger, ED; Kreienkamp, HJ; Kreutz, MR,期刊:Journal of Biological Chemistry, 页码:25431-25440 , 文章类型: Article,,卷期:2009年284-37]
- Jacob is a recently identified plasticity-related protein that couples N-methyl-D-aspartate receptor activity to nuclear gene expression. An expression analysis by Northern blot and in situ hybridization shows that Jacob...
- Calpain-1 Cleaves and Activates Caspase-7
[作者:Gafni, J; Cong, X; Chen, SF; Gibson, BW; Ellerby, LM,期刊:Journal of Biological Chemistry, 页码:25441-25449 , 文章类型: Article,,卷期:2009年284-37]
- Caspase-7 is an executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases. The mechanism of caspase-7 activation by granzyme B and caspase-3 has been well characterized. H...
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