- Sites in the AAV5 capsid tolerant to deletions and tandem duplications
[作者:Hida, K; Won, SY; Di Pasquale, G; Hanes, J; Chiorini, JA; Ostermeier, M,期刊:Archives of Biochemistry and Biophysics , 页码:1-8 , 文章类型: Article,,卷期:2010年496-1]
- Gene therapy vectors based on adeno-associated virus (AAV) have shown much promise in clinical trials for the treatment of a variety of diseases. However, the ability to manipulate and engineer the viral surface for enha...
- The novel metalloproteinase atroxlysin-I from Peruvian Bothrops atrox (Jergon) snake venom acts both on blood vessel ECM and platelets
[作者:Sanchez, EF; Schneider, FS; Yarleque, A; Borges, MH; Richardson, M; Figueiredo, SG; Evangelista, KS; Eble, JA,期刊:Archives of Biochemistry and Biophysics , 页码:9-20 , 文章类型: Article,,卷期:2010年496-1]
- We report the isolation and structure-function relationship of a 23 kDa metalloproteinase named atroxlysin-I from the venom of the Peruvian Bothrops atrox (Jergon). Atroxlysin is a P-I metalloproteinase and contains 204 ...
- Purification and characterization of the ouabain-sensitive H+/K+-ATPase from guinea-pig distal colon
[作者:Belisario, DC; Rocafull, MA; del Castillo, JR,期刊:Archives of Biochemistry and Biophysics , 页码:21-32 , 文章类型: Article,,卷期:2010年496-1]
- Distal colon absorbs K+ through a Na+-independent, ouabain-sensitive H+/K+-exchange, associated to an apical ouabain-sensitive H+/K+-ATPase. Expression of HK alpha 2, gene associated with this ATPase, induces K+-transpor...
- Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice
[作者:Amano, A; Aigaki, T; Maruyama, N; Ishigami, A,期刊:Archives of Biochemistry and Biophysics , 页码:38-44 , 文章类型: Article,,卷期:2010年496-1]
- In this study, we examined whether ascorbic acid (AA) and dehydroascorbic acid (DHA), the oxidized form of AA, levels in tissues regulate the AA transporters, sodium-dependent vitamin C transporters (SVCT) 1 and SVCT2 an...
- Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse
[作者:Da Silva, D; Zancan, P; Coelho, WS; Gomez, LS; Sola-Penna, M,期刊:Archives of Biochemistry and Biophysics , 页码:53-60 , 文章类型: Article,,卷期:2010年496-1]
- The present work describes the effects of metformin on hexokinase (HK) and phosphofructokinase (PFK) activities and localization in different tissues from streptozotocin-induced diabetic mice. Diabetic mice present lower...
- Barley xyloglucan xyloglucosyl transferases bind xyloglucan-derived oligosaccharides in their acceptor-binding regions in multiple conformational states
[作者:Vaaje-Kolstad, G; Farkas, V; Fincher, GB; Hrmova, M,期刊:Archives of Biochemistry and Biophysics , 页码:61-68 , 文章类型: Article,,卷期:2010年496-1]
- Three barley xyloglucan endotransglycosylases (HvXETs), known as xyloglucan xyloglucosyl transferases (EC 2.4.1.207), were subjected to kinetic and computational docking studies. The k(cat).K-m(-1) values with the reduce...
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