- Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines
[作者：Kattman, SJ; Witty, AD; Gagliardi, M; Dubois, NC; Niapour, M; Hotta, A; Ellis, J; Keller, G,期刊：Cell Stem Cell, 页码：228-240 , 文章类型： Article，,卷期：2011年8-2]
- Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) to a variety of lineages requires step-wise approaches replicating the key commitment stages found during embryonic deve...
- An Epigenetic Tet a Tet with Pluripotency
[作者：Walter, J,期刊：Cell Stem Cell, 页码：121-122 , 文章类型： Editorial Material，,卷期：2011年8-2]
- DNA and chromatin-modifying enzymes establish an ESC/iPSC-specific epigenomic landscape that is linked to a network of pluripotency genes and influences differentiation potential. In this issue of Cell Stem Cell, Koh et ...
- What Your Heart Doth Know
[作者：Willems, E; Mercola, M,期刊：Cell Stem Cell, 页码：124-126 , 文章类型： Editorial Material，,卷期：2011年8-2]
- Combining embryological insight with careful analysis of early stage cardiomyocyte differentiation, Kattman et al. (2011) in this issue of Cell Stem Cell have defined minimal culture conditions to efficiently produce car...
- A Twist of Cell Fate
[作者：Tlsty, TD,期刊：Cell Stem Cell, 页码：126-127 , 文章类型： Editorial Material，,卷期：2011年8-2]
- Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal breast cancers. In this issue of Cell Stem Cell, Proia et al. (2011) study breast tissue from women with heterozygous BRCA...
- Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
[作者：Proia, TA; Keller, PJ; Gupta, PB; Klebba, I; Jones, AD; Sedic, M; Gilmore, H; Tung, N; Naber, SP; Schnitt, S; Lander, ES; Kuperwasser, C,期刊：Cell Stem Cell, 页码：149-163 , 文章类型： Article，,卷期：2011年8-2]
- Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast ep...
- Delta Np630 alpha Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis
[作者：Keyes, WM; Pecoraro, M; Aranda, V; Vernersson-Lindahl, E; Li, WZ; Vogel, H; Guo, XC; Garcia, EL; Michurina, TV; Enikolopov, G; Muthuswamy, SK; Mills, AA,期刊：Cell Stem Cell, 页码：164-176 , 文章类型： Article，,卷期：2011年8-2]
- The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor-suppressive mechanism of cellular senescence, causing a striking absence of strati...
- Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
[作者：Tanimura, S; Tadokoro, Y; Inomata, K; Nguyen, TB; Nishie, W; Yamazaki, S; Nakauchi, H; Tanaka, Y; McMillan, JR; Sawamura, D; Yancey, K; Shimizu, H; Nishimura, EK,期刊：Cell Stem Cell, 页码：177-187 , 文章类型： Article，,卷期：2011年8-2]
- In most stem cell systems, the organization of the stem cell niche and the anchoring matrix required for stem cell maintenance are largely unknown. We report here that collagen XVII (COL17A1/BP180/BPAG2), a hemidesmosoma...
- Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
[作者：Hochmuth, CE; Biteau, B; Bohmann, D; Jasper, H,期刊：Cell Stem Cell, 页码：188-199 , 文章类型： Article，,卷期：2011年8-2]
- In Drosophila, intestinal stem cells (ISCs) respond to oxidative challenges and inflammation by increasing proliferation rates. This phenotype is part of a regenerative response, but can lead to hyperproliferation and ep...
- Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
[作者：Koh, KP; Yabuuchi, A; Rao, S; Huang, Y; Cunniff, K; Nardone, J; Laiho, A; Tahiliani, M; Sommer, CA; Mostoslavsky, G; Lahesmaa, R; Orkin, SH; Rodig, SJ; Daley, GQ; Rao, A,期刊：Cell Stem Cell, 页码：200-213 , 文章类型： Article，,卷期：2011年8-2]
- TET family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain 5hmC in mouse embryonic stem cells (ESCs) and ...
- beta-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism
[作者：Kelly, KF; Ng, DY; Jayakumaran, G; Wood, GA; Koide, H; Doble, BW,期刊：Cell Stem Cell, 页码：214-227 , 文章类型： Article，,卷期：2011年8-2]
- Understanding the mechanisms regulating pluripotency in embryonic and induced pluripotent stem cells is required to ensure their safe use in clinical applications. Glycogen synthase kinase-3 (GSK-3) has emerged as an imp...
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