- Hydrating for Resistance to Radicicol
[作者:DUERFELDT ADAM S; BLAGG BRIAN S J,期刊:ACS CHEMICAL BIOLOGY, 页码:245-247 , 文章类型: Article,,卷期:2009年4-4]
- Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided...
- Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90
[作者:PRODROMOU CHRISOSTOMOS; NUTTALL JAMES M; MILLSON STEFAN H; ROE S MARK; SIM TIOWSUAN; TAN DOREEN; WORKMAN PAUL; PEARL LAURENCE H; PIPER PETER W,期刊:ACS CHEMICAL BIOLOGY, 页码:289-297 , 文章类型: Article,,卷期:2009年4-4]
- Heat shock protein 90 (Hsp90) is a promising cancer drug target, as multiple oncogenic proteins are destabilized simultaneously when it loses its activity in tumor cells. Highly selective Hsp90 inhibitors, including the ...
|