- Targeting the Lung Using siRNA and Antisense Based Oligonucleotides
[作者:Moschos, SA; Spinks, K; Williams, AE; Lindsay, MA,期刊:Current Pharmaceutical Design, 页码:3620-3627 , 文章类型: Review,,卷期:2008年14-34]
- The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeu...
- Peptide-Based Nanoparticle for Ex Vivo and In Vivo Dug Delivery
[作者:Crombez, L; Morris, MC; Deshayes, S; Heitz, F; Divita, G,期刊:Current Pharmaceutical Design, 页码:3656-3665 , 文章类型: Review,,卷期:2008年14-34]
- One of the major challenges for new therapeutics molecules to enter the clinic remains improving their bioavailability and cellular uptake. Therefore, delivery has become a key stone in therapeutic development and severa...
- Phosphorothioate-Stimulated Cellular Uptake of siRNA: A Cell Culture Model for Mechanistic Studies
[作者:Detzer, A; Overhoff, M; Mescalchin, A; Rompf, M; Sczakiel, G,期刊:Current Pharmaceutical Design, 页码:3666-3673 , 文章类型: Review,,卷期:2008年14-34]
- The phosphorothioate(PS)-stimulated cellular uptake of naked short interfering RNA ( siRNA) into mammalian cells indicates a promising new mechanistic strategy because it makes use of a caveosomal, rather than an endosom...
- Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo
[作者:Oliveira, S; Hogset, A; Storm, G; Schiffelers, M,期刊:Current Pharmaceutical Design, 页码:3686-3697 , 文章类型: Review,,卷期:2008年14-34]
- The prospect of introducing siRNA in a cell, to induce silencing of the corresponding gene, has encouraged research into RNAi-based therapeutics as treatment for human diseases. At present, the siRNA molecules that are i...
|