- Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity
[作者:Murano, K; Okuwaki, M; Hisaoka, M; Nagata, K,期刊:Molecular and Cellular Biology, 页码:3114-3126 , 文章类型: Article,,卷期:2008年28-10]
- It is well established that the transcription rate of the rRNA gene is closely associated with profound alterations in the cell growth rate. Regulation of rRNA gene transcription is likely to be dependent on the dynamic ...
- Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
[作者:Yang, TTC; Yu, RYL; Agadir, A; Gao, GJ; Campos-Gonzalez, R; Tournier, C; Chow, CW,期刊:Molecular and Cellular Biology, 页码:3489-3501 , 文章类型: Article,,卷期:2008年28-10]
- The target of rapamycin (TOR) signaling regulates the nucleocytoplasmic shuttling of transcription factors in yeast. Whether the mammalian counterpart of TOR (mTOR) also regulates nucleocytoplasmic shuttling is not known...
- ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-J kappa/SHARP-mediated repression of Notch target genes
[作者:Salat, D; Liefke, R; Wiedenmann, J; Borggrefe, T; Oswald, F,期刊:Molecular and Cellular Biology, 页码:3502-3512 , 文章类型: Article,,卷期:2008年28-10]
- Notch is a transmembrane receptor that determines cell fates and pattern formation in all animal species. After specific ligand binding, the intracellular part of Notch is cleaved off and translocates to the nucleus, whe...
- The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression
[作者:Hou, ZY; Peng, HZ; Ayyanathan, K; Yan, KP; Langer, EM; Longmore, GD; Rauscher, FJ,期刊:Molecular and Cellular Biology, 页码:3198-3207 , 文章类型: Article,,卷期:2008年28-10]
- The SNAIL transcription factor contains C-terminal tandem zinc finger motifs and an N-terminal SNAG repression domain. The members of the SNAIL family have recently emerged as major contributors to the processes of devel...
- Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum
[作者:Choi, MY; Romer, AI; Wang, Y; Wu, MP; Ito, S; Leiter, AB; Shivdasani, RA,期刊:Molecular and Cellular Biology, 页码:3208-3218 , 文章类型: Article,,卷期:2008年28-10]
- Many homeodomain transcription factors function in organogenesis and cell differentiation. The Nkx family illustrates these functions especially well, and the Nkx6 subfamily controls differentiation in the central nervou...
- A regulatory role of the Rnq1 nonprion domain for prion propagation and polyglutamine aggregates
[作者:Kurahashi, H; Ishiwata, M; Shibata, S; Nakamura, Y,期刊:Molecular and Cellular Biology, 页码:3313-3323 , 文章类型: Article,,卷期:2008年28-10]
- Prions are infectious, self-propagating protein conformations. Rnq1 is required for the yeast Saccharomyces cerevisiae prion [PIN+], which is necessary for the de novo induction of a second prion, [PSI+]. Here we isolate...
- Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin
[作者:Sustmann, C; Flach, H; Ebert, H; Eastman, Q; Grosschedl, R,期刊:Molecular and Cellular Biology, 页码:3526-3537 , 文章类型: Article,,卷期:2008年28-10]
- Transcriptional regulation by the canonical Wnt pathway involves the stabilization and nuclear accumulation of beta-catenin, which assembles with LEF1/TCF transcription factors and cofactors to activate Wnt target genes....
- Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter
[作者:Wu, LP; Wang, X; Li, L; Zhao, Y; Lu, SL; Yu, Y; Zhou, W; Liu, XY; Yang, J; Zheng, ZX; Zhang, H; Feng, JN; Yang, Y; Wang, HY; Zhu, WG,期刊:Molecular and Cellular Biology, 页码:3219-3235 , 文章类型: Article,,卷期:2008年28-10]
- Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression. He...
- Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling
[作者:Losev, E; Papanikou, E; Rossanese, OW; Glick, BS,期刊:Molecular and Cellular Biology, 页码:3336-3343 , 文章类型: Article,,卷期:2008年28-10]
- In the budding yeast Saccharomyces cerevisiae, mutations in the essential gene CDC1 cause defects in Golgi inheritance and actin polarization. However, the biochemical function of Cdc1p is unknown. Previous work showed t...
- Transforming growth factor alpha (TGF alpha)-stimulated secretion of HSP90 alpha: Using the receptor LRF-1/CD91 to promote human skin cell migration against a TGF beta-rich environment during wound healing
[作者:Cheng, CF; Fan, JH; Fedesco, M; Guan, SX; Li, Y; Bandyopadhyay, B; Bright, AM; Yerushalmi, D; Liang, MM; Chen, M; Han, YP; Woodley, DT; Li, W,期刊:Molecular and Cellular Biology, 页码:3344-3358 , 文章类型: Article,,卷期:2008年28-10]
- Jump-starting and subsequently maintaining epidermal and dermal cell migration are essential processes for skin wound healing. These events are often disrupted in nonhealing wounds, causing patient morbidity and even fat...
- Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and Toll-like receptor-mediated NF-kappa B activation
[作者:Conze, DB; Wu, CJ; Thomas, JA; Landstrom, A; Ashwell, JD,期刊:Molecular and Cellular Biology, 页码:3538-3547 , 文章类型: Article,,卷期:2008年28-10]
- Stimulation through the interleukin-1 receptor (IL-1R) and some Toll-like receptors (TLRs) induces ubiquitination of TRAF6 and IRAK-1, signaling components required for NF-kappa B and mitogen-activated protein kinase act...
- The U11-48K protein contacts the 5 ' splice site of U12-type introns and the U11-59K protein
[作者:Turunen, JJ; Will, CL; Grote, M; Lurhrmann, R; Frilander, MJ,期刊:Molecular and Cellular Biology, 页码:3548-3560 , 文章类型: Article,,卷期:2008年28-10]
- Little is currently known about proteins that make contact with the pre-mRNA in the U12-dependent spliceosome and thereby contribute to intron recognition. Using site-specific cross-linking, we detected an interaction be...
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