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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共28条记录   The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast [作者：Trickey, M; Grimaldi, M; Yamano, H,期刊：Molecular and Cellular Biology, 页码：3905-3916 , 文章类型： Article，,卷期：2008年28-12] Homologous recombination (HR) is important for maintaining genome integrity and for the process of meiotic chromosome segregation and the generation of variation. HR is regulated throughout the cell cycle, being prevalen... Hepatocyte nuclear factor 4 alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9 [作者：Ohguchi, H; Tanaka, T; Uchida, A; Magoori, K; Kudo, H; Kim, I; Daigo, K; Sakakibara, I; Okamura, M; Harigae, H; Sasaki, T; Osborne, TF; Gonzalez, FJ; Hamakubo, T; Kodama, T; Sakai, J,期刊：Molecular and Cellular Biology, 页码：3917-3931 , 文章类型： Article，,卷期：2008年28-12] Type 1 iodothyronine deiodinase (Dio1), a selenoenzyme catalyzing the bioactivation of thyroid hormone, is highly expressed in the liver. Diol mRNA and enzyme activity levels are markedly reduced in the livers of hepatoc... MED1 phosphorylation promotes its association with Mediator: Implications for nuclear receptor signaling [作者：Belakavadi, M; Pandey, PK; Vijayvargia, R; Fondell, JD,期刊：Molecular and Cellular Biology, 页码：3932-3942 , 文章类型： Article，,卷期：2008年28-12] Mediator is a conserved multisubunit complex that acts as a functional interface between regulatory transcription factors and the general RNA polymerase II initiation apparatus. MED1 is a pivotal component of the complex... Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress [作者：Upton, JP; Austgen, K; Nishino, M; Coakley, KM; Hagen, A; Han, D; Papa, FR; Oakes, SA,期刊：Molecular and Cellular Biology, 页码：3943-3951 , 文章类型： Article，,卷期：2008年28-12] The accumulation of misfolded proteins stresses the endoplasmic reticulum (ER) and triggers cell death through activation of the multidomain proapoptotic BCL-2 proteins BAX and BAK at the outer mitochondrial membrane. Th... A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response [作者：Audas, TE; Li, Y; Liang, GQ; Lu, R,期刊：Molecular and Cellular Biology, 页码：3952-3966 , 文章类型： Article，,卷期：2008年28-12] Luman/CREB3 (also called LZIP) is an endoplasmic reticulum (ER)-bound cellular transcription factor. It has been implicated in the mammalian unfolded protein response (UPR), as well as herpes simplex virus reactivation f... Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis [作者：Sue, N; Jack, BHA; Eaton, SA; Pearson, RCM; Funnell, APW; Turner, J; Czolij, R; Denyer, G; Bao, SS; Molero-Navajas, JC; Perkins, A; Fujiwara, Y; Orkin, SH; Bell-Anderson, K; Crossley, M,期刊：Molecular and Cellular Biology, 页码：3967-3978 , 文章类型： Article，,卷期：2008年28-12] Kruppel-like factors (KLFs) recognize CACCC and GC-rich sequences in gene regulatory elements. Here, we describe the disruption of the murine basic Kruppel-like factor gene (Bklf or Klf3). Klf3 knockout mice have less wh... Sir2 silences gene transcription by targeting the transition between RNA polymerase II initiation and elongation [作者：Gao, L; Gross, DS,期刊：Molecular and Cellular Biology, 页码：3979-3994 , 文章类型： Article，,卷期：2008年28-12] It is well accepted that for transcriptional silencing in budding yeast, the evolutionarily conserved lysine deacetylase Sir2, in concert with its partner proteins Sir3 and Sir4, establishes a chromatin structure that pr... Transrepressive function of TLX requires the histone demethylase LSD1 [作者：Yokoyama, A; Takezawa, S; Schule, R; Kitagawa, H; Kato, S,期刊：Molecular and Cellular Biology, 页码：3995-4003 , 文章类型： Article，,卷期：2008年28-12] TLX is an orphan nuclear receptor (also called NR2E1) that regulates the expression of target genes by functioning as a constitutive transrepressor. The physiological significance of TLX in the cytodifferentiation of neu... Identification of proteins associating with glycosylphosphatidylinositol-anchored T-cadherin on the surface of vascular endothelial cells: Role for Grp78/BiP in T-cadherin-dependent cell survival [作者：Philippova, M; Ivanov, D; Joshi, MB; Kyriakakis, E; Rupp, K; Afonyushkin, T; Bochkov, V; Erne, P; Resink, TJ,期刊：Molecular and Cellular Biology, 页码：4004-4017 , 文章类型： Article，,卷期：2008年28-12] There is scant knowledge regarding how cell surface lipid-anchored T-cadherin (T-cad) transmits signals through the plasma membrane to its intracellular targets. This study aimed to identify membrane proteins colocalizin... CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control [作者：Min, JN; Whaley, RA; Sharpless, NE; Lockyer, P; Portbury, AL; Patterson, C,期刊：Molecular and Cellular Biology, 页码：4018-4025 , 文章类型： Article，,卷期：2008年28-12] During the course of biological aging, there is a gradual accumulation of damaged proteins and a concomitant functional decline in the protein degradation system. Protein quality control is normally ensured by the coordi... Emilin1 deficiency causes structural and functional defects of lymphatic vasculature [作者：Danussi, C; Spessotto, P; Petrucco, A; Wassermann, B; Sabatelli, P; Montesi, M; Doliana, R; Bressan, GM; Colombatti, A,期刊：Molecular and Cellular Biology, 页码：4026-4039 , 文章类型： Article，,卷期：2008年28-12] Lymphatic-vasculature function critically depends on extracellular matrix (ECM) and on its connections with lymphatic endothelial cells (LECs). However, the composition and the architecture of ECM have not been fully tak... How antigen quantity and quality determine T-cell decisions in lymphoid tissue [作者：Zheng, H; Jin, B; Henrickson, SE; Perelson, AS; von Andrian, UH; Chakraborty, AK,期刊：Molecular and Cellular Biology, 页码：4040-4051 , 文章类型： Article，,卷期：2008年28-12] T lymphocytes (T cells) express T-cell receptor (TCR) molecules on their surface that can recognize peptides (p) derived from antigenic proteins bound to products of the major histocompatibility complex (MHC) genes. The ... Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation [作者：Georges, R; Nemer, G; Morin, M; Lefebvre, C; Nemer, M,期刊：Molecular and Cellular Biology, 页码：4052-4067 , 文章类型： Article，,卷期：2008年28-12] Mutations in the T-box transcription factor Tbx5 cause Holt-Oram syndrome, an autosomal dominant disease characterized by a wide spectrum of cardiac and upper limb defects with variable expressivity. Tbx5 haploinsufficie... The neogenin intracellular domain regulates gene transcription via nuclear translocation [作者：Goldschneider, D; Rama, N; Guix, C; Mehlen, P,期刊：Molecular and Cellular Biology, 页码：4068-4079 , 文章类型： Article，,卷期：2008年28-12] Neogenin is a multifunctional receptor implicated in axon navigation, neuronal differentiation, morphogenesis, and cell death. Very little is known about signaling downstream of neogenin. Because we found that the neogen... DEC1 modulates the circadian phase of clock gene expression [作者：Nakashima, A; Kawamoto, T; Honda, KK; Ueshima, T; Noshiro, M; Iwata, T; Fujimoto, K; Kubo, H; Honma, S; Yorioka, N; Kohno, N; Kato, Y,期刊：Molecular and Cellular Biology, 页码：4080-4092 , 文章类型： Article，,卷期：2008年28-12] DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear. Here we examined the effect of Dec1 overexpression or deficiency on circadian gene expression trigg... Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets [作者：Morris, AR; Mukherjee, N; Keene, JD,期刊：Molecular and Cellular Biology, 页码：4093-4103 , 文章类型： Article，,卷期：2008年28-12] PUF family proteins are among the best-characterized regulatory RNA-binding proteins in nonmammalian species, but relatively little is known about mRNA targets or functions of mammalian PUF proteins. In this study, we us...