- Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: Dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding
[作者:Butler, GS; Dean, RA; Tam, EM; Overall, CM,期刊:Molecular and Cellular Biology, 页码:4896-4914 , 文章类型: Review,,卷期:2008年28-15]
- Broad-spectrum matrix metalloproteinase (MMP) inhibitors (MMPI) were unsuccessful in cancer clinical trials, partly due to side effects resulting from limited knowledge of the full repertoire of MMP substrates, termed th...
- Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: Role of p53, NF-Y, and p38 mitogen-activated protein kinase
[作者:Lecona, E; Barrasa, JI; Olmo, N; Llorente, B; Turnay, J; Lizarbe, MA,期刊:Molecular and Cellular Biology, 页码:4665-4674 , 文章类型: Article,,卷期:2008年28-15]
- Annexin A1 is a member of a phospholipid and calcium binding family of proteins; it is involved in anti-inflammation and in the regulation of differentiation, proliferation, and apoptosis. Here, we show the existence of ...
- Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors
[作者:Hoser, M; Potzner, MR; Koch, JMC; Bosl, MR; Wegner, M; Sock, E,期刊:Molecular and Cellular Biology, 页码:4675-4687 , 文章类型: Article,,卷期:2008年28-15]
- The transcription factors Sox4 and Sox11 are important regulators of diverse developmental processes including heart, lung, pancreas, spleen, and B-cell development. Here we have studied the role of the related Sox12 as ...
- Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster
[作者:Lange, UC; Adams, DJ; Lee, C; Barton, S; Schneider, R; Bradley, A; Surani, MA,期刊:Molecular and Cellular Biology, 页码:4688-4696 , 文章类型: Article,,卷期:2008年28-15]
- The family of interferon-inducible transmembrane proteins (Ifitm) consists of five highly sequence-related cell surface proteins, which are implicated in diverse cellular processes. Ifitm genes are conserved, widely expr...
- A novel heme-regulatory motif mediates heme-dependent degradation of the circadian factor period 2
[作者:Yang, JH; Kim, KD; Lucas, A; Drahos, KE; Santos, CS; Mury, SP; Capelluto, DGS; Finkielstein, CV,期刊:Molecular and Cellular Biology, 页码:4697-4711 , 文章类型: Article,,卷期:2008年28-15]
- Although efforts have been made to identify circadian-controlled genes regulating cell cycle progression and cell death, little is known about the metabolic signals modulating circadian regulation of gene expression. We ...
- Regulation of p53 target gene expression by peptidylarginine deiminase 4
[作者:Li, PX; Yao, HJ; Zhang, ZQ; Li, M; Luo, Y; Thompson, PR; Gilmour, DS; Wang, YM,期刊:Molecular and Cellular Biology, 页码:4745-4758 , 文章类型: Article,,卷期:2008年28-15]
- Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear. Here, we report th...
- Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
[作者:Puddu, F; Granata, M; Di Nola, L; Balestrini, A; Piergiovanni, G; Lazzaro, F; Giannattasio, M; Plevani, P; Muzi-Falconi, M,期刊:Molecular and Cellular Biology, 页码:4782-4793 , 文章类型: Article,,卷期:2008年28-15]
- Following genotoxic insults, eukaryotic cells trigger a signal transduction cascade known as the DNA damage checkpoint response, which involves the loading onto DNA of an apical kinase and several downstream factors. Chr...
- Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches
[作者:Yoon, MJ; Koo, BK; Song, R; Jeong, HW; Shin, J; Kim, YW; Kong, YY; Suh, PG,期刊:Molecular and Cellular Biology, 页码:4794-4804 , 文章类型: Article,,卷期:2008年28-15]
- Intraembryonic hematopoiesis occurs at two different sites, the floor of the aorta and subaortic patches (SAPs) of the para-aortic splanchnopleura (P-Sp)/aorta-gonad-mesonephros (AGM) region. Notch1 and RBP-j kappa are c...
- The activated notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity
[作者:Hsu, KW; Hsieh, RH; Lee, YHW; Chao, CH; Wu, KJ; Tseng, MJ; Yeh, TS,期刊:Molecular and Cellular Biology, 页码:4829-4842 , 文章类型: Article,,卷期:2008年28-15]
- The Notch signal pathway plays multifaceted roles to promote or suppress tumorigenesis. The Notch1 receptor intracellular domain (N1IC), the activated form of the Notch1 receptor, activates the c-myc protooncogene. The c...
- Deletion of Vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos
[作者:Haiko, P; Makinen, T; Keskitalo, S; Taipale, J; Karkkainen, MJ; Baldwin, ME; Stacker, SA; Achen, MG; Alitalo, K,期刊:Molecular and Cellular Biology, 页码:4843-4850 , 文章类型: Article,,卷期:2008年28-15]
- Lymphatic vessels play an important role in the regulation of tissue fluid balance, immune responses, and fat adsorption and are involved in diseases including lymphedema and tumor metastasis. Vascular endothelial growth...
- Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density
[作者:Ellwanger, K; Saito, H; Clement-Lacroix, P; Maltry, N; Niedermeyer, J; Lee, WK; Baron, R; Rawadi, G; Westphal, H; Niehrs, C,期刊:Molecular and Cellular Biology, 页码:4875-4882 , 文章类型: Article,,卷期:2008年28-15]
- Kremen1 and Kremen2 (Krm1 and Krm2) are transmembrane coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/beta-catenin signaling. The physiological relevance of Kremen proteins in mammals as Writ modulators is unresol...
- The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation
[作者:Mohseni, M; Chishti, AH,期刊:Molecular and Cellular Biology, 页码:4712-4718 , 文章类型: Article,,卷期:2008年28-15]
- RhoA is known to participate in cytoskeletal remodeling events through several signaling pathways, yet the precise mechanism of its activation remains unknown. Here, we provide the first evidence that dematin functions u...
- Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons
[作者:Farah, CA; Nagakura, I; Weatherill, D; Fan, XT; Sossin, WS,期刊:Molecular and Cellular Biology, 页码:4719-4733 , 文章类型: Article,,卷期:2008年28-15]
- In Aplysia californica, the serotonin-mediated translocation of protein kinase C (PKC) Apl II to neuronal membranes is important for synaptic plasticity. The orthologue of PKC Apl II, PKC epsilon, has been reported to re...
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