- Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes
[作者:Bittencourt, D; Dutertre, M; Sanchez, G; Barbier, J; Gratadou, L; Auboeuf, D,期刊:Molecular and Cellular Biology, 页码:5811-5824 , 文章类型: Article,,卷期:2008年28-18]
- While early steps of gene expression, such as transcription preinitiation, are known to often be rate limiting and to be regulated by such stimuli as steroid hormones, the potential impact of downstream steps, including ...
- Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis
[作者:Zhang, Y; Lyver, ER; Nakamaru-Ogiso, E; Yoon, H; Amutha, B; Lee, DW; Bi, E; Ohnishi, T; Daldal, F; Pain, D; Dancis, A,期刊:Molecular and Cellular Biology, 页码:5569-5582 , 文章类型: Article,,卷期:2008年28-18]
- In a forward genetic screen for interaction with mitochondrial iron carrier proteins in Saccharomyces cerevisiae, a hypomorphic mutation of the essential DRE2 gene was found to confer lethality when combined with Delta m...
- Xist RNA is confined to the nuclear territory of the silenced X chromosome throughout the cell cycle
[作者:Jonkers, I; Monkhorst, K; Rentmeester, E; Grootegoed, JA; Grosveld, F; Gribnau, J,期刊:Molecular and Cellular Biology, 页码:5583-5594 , 文章类型: Article,,卷期:2008年28-18]
- In mammalian female cells, one X chromosome is inactivated to prevent a dose difference in the expression of X-encoded proteins between males and females. Xist RNA, required for X chromosome inactivation, is transcribed ...
- Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development
[作者:McCall, CM; de Marval, PLM; Chastain, PD; Jackson, SC; He, YJ; Kotake, Y; Cook, JG; Xiong, Y,期刊:Molecular and Cellular Biology, 页码:5621-5633 , 文章类型: Article,,卷期:2008年28-18]
- Damaged DNA binding protein 1, DDB1, bridges an estimated 90 or more WD40 repeats (DDB1-binding WD40, or DWD proteins) to the CUL4-ROC1 catalytic core to constitute a potentially large number of E3 ligase complexes. Amon...
- Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism
[作者:Oriente, F; Diaz, LCF; Miele, C; Iovino, S; Mori, S; Diaz, VM; Troncone, G; Cassese, A; Formisano, P; Blasi, F; Beguinot, F,期刊:Molecular and Cellular Biology, 页码:5634-5645 , 文章类型: Article,,卷期:2008年28-18]
- We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucos...
- A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response
[作者:Seidel, JJ; Anderson, CM; Blackburn, EH,期刊:Molecular and Cellular Biology, 页码:5736-5746 , 文章类型: Article,,卷期:2008年28-18]
- Tel1/ATM, a conserved phosphatidylinositol 3-kinase-related kinase (PIKK), acts in the response to DNA damage and regulates telomere maintenance. PIKK family members share an extended N-terminal region of low sequence ho...
- Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes
[作者:Lu, TC; Wang, ZH; Feng, XB; Chuang, P; Fang, W; Chen, YB; Neves, S; Maayan, A; Xiong, HB; Liu, YS; Iyengar, R; Klotman, PE; He, JC,期刊:Molecular and Cellular Biology, 页码:5785-5794 , 文章类型: Article,,卷期:2008年28-18]
- Nef-induced podocyte proliferation and dedifferentiation via mitogen-activated protein kinase 1,2 (MAPK1,2) activation plays a role in human immunodeficiency virus (HIV) nephropathy pathogenesis. All-trans retinoic acid ...
- Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
[作者:Wang, SE; Xian, B; Guix, M; Olivares, MG; Parker, J; Chung, CH; Pandiella, A; Arteaga, CL,期刊:Molecular and Cellular Biology, 页码:5605-5620 , 文章类型: Article,,卷期:2008年28-18]
- In HER2-overexpressing mammary epithelial cells, transforming growth factor beta (TGF-beta) activated phosphatidylinositol-3 kinase (PI3K)/Akt and enhanced survival and migration. Treatment with TGF-beta or expression of...
- Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation
[作者:Gao, CZ; Ho, CC; Reineke, E; Lam, M; Cheng, XW; Stanya, KJ; Liu, Y; Chakraborty, S; Shih, HM; Kao, HY,期刊:Molecular and Cellular Biology, 页码:5658-5667 , 文章类型: Article,,卷期:2008年28-18]
- Promyelocytic leukemia protein (PML) sumoylation has been proposed to control the formation of PML nuclear bodies (NBs) and is crucial for PML-dependent cellular processes, including apoptosis and transcriptional regulat...
- Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells
[作者:Martinsson-Ahlzen, HS; Liberal, V; Grunenfelder, B; Chaves, SR; Spruck, CH; Reed, SI,期刊:Molecular and Cellular Biology, 页码:5698-5709 , 文章类型: Article,,卷期:2008年28-18]
- Cks proteins associate with cyclin-dependent kinases and have therefore been assumed to play a direct role in cell cycle regulation. Mammals have two paralogs, Cks1 and Cks2, and individually deleting the gene encoding e...
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