- Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons
[作者:Shimizu, H; Shimoda, M; Yamaguchi, T; Seong, KH; Okamura, T; Ishii, S,期刊:Molecular and Cellular Biology, 页码:6278-6289 , 文章类型: Article,,卷期:2008年28-20]
- Stress-activated protein kinases such as p38 regulate the activity of transcription factor ATF-2. However, the physiological role of ATF-2, especially in the brain, is unknown. Here, we found that Drosophila melanogaster...
- SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
[作者:Sundaresan, NR; Samant, SA; Pillai, VB; Rajamohan, SB; Gupta, MP,期刊:Molecular and Cellular Biology, 页码:6384-6401 , 文章类型: Article,,卷期:2008年28-20]
- There are seven SIRT isoforms in mammals, with diverse biological functions including gene regulation, metabolism, and apoptosis. Among them, SIRT3 is the only sirtuin whose increased expression has been shown to correla...
- Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host
[作者:Mikolajczak, SA; Silva-Rivera, H; Peng, XX; Tarun, AS; Camargo, N; Jacobs-Lorena, V; Daly, TM; Bergman, LW; de la Vega, P; Williams, J; Aly, ASI; Kappe, SHI,期刊:Molecular and Cellular Biology, 页码:6196-6207 , 文章类型: Article,,卷期:2008年28-20]
- The malaria parasite sporozoite transmission stage develops and differentiates within parasite oocysts on the Anopheles mosquito midgut. Successful inoculation of the parasite into a mammalian host is critically dependen...
- CSIG inhibits PTEN translation in replicative senescence
[作者:Ma, LW; Chang, N; Guo, SZ; Li, Q; Zhang, ZY; Wang, WG; Tong, TJ,期刊:Molecular and Cellular Biology, 页码:6290-6301 , 文章类型: Article,,卷期:2008年28-20]
- Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) that was abundant in young human diploid fibroblast cells but declined upon replicative senesc...
- Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization
[作者:Muehlich, S; Wang, RG; Lee, SM; Lewis, TC; Dai, C; Prywes, R,期刊:Molecular and Cellular Biology, 页码:6302-6313 , 文章类型: Article,,卷期:2008年28-20]
- Megakaryoblastic leukemia 1 (MKL1) is a myocardin-related coactivator of the serum response factor (SRF) transcription factor, which has an integral role in differentiation, migration, and proliferation. Serum induces Rh...
- The association of Notch2 and NF-kappa B accelerates RANKL-induced osteoclastogenesis
[作者:Fukushima, H; Nakao, A; Okamoto, F; Shin, M; Kajiya, H; Sakano, S; Bigas, A; Jimi, E; Okabe, K,期刊:Molecular and Cellular Biology, 页码:6402-6412 , 文章类型: Article,,卷期:2008年28-20]
- Notch signaling plays a key role in various cell differentiation processes including bone homeostasis. However, the specific involvement of Notch in regulating osteoclastogenesis is still controversial. In the present st...
- Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages
[作者:Achuthan, A; Masendycz, P; Lopez, JA; Nguyen, T; James, DE; Sweet, MJ; Hamilton, JA; Scholz, GM,期刊:Molecular and Cellular Biology, 页码:6149-6159 , 文章类型: Article,,卷期:2008年28-20]
- Colony-stimulating factor 1 (CSF-1) is the main growth factor controlling the development of macrophages from myeloid progenitor cells. However, CSF-1 also regulates some of the key effector functions of macrophages (e. ...
- CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappa B and of NF-kappa B-mediated de novo synthesis of IRF-1
[作者:Moschonas, A; Kouraki, M; Knox, PG; Thymiakou, E; Kardassis, D; Eliopoulos, AG,期刊:Molecular and Cellular Biology, 页码:6208-6222 , 文章类型: Article,,卷期:2008年28-20]
- Cancer cells may evade immune surveillance as a result of defective antigen processing and presentation. In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transc...
- Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability
[作者:McKenna, ES; Sansam, CG; Cho, YJ; Greulich, H; Evans, JA; Thom, CS; Moreau, LA; Biegel, JA; Pomeroy, SL; Roberts, CWM,期刊:Molecular and Cellular Biology, 页码:6223-6233 , 文章类型: Article,,卷期:2008年28-20]
- There is a growing appreciation of the role that epigenetic alterations can play in oncogenesis. However, given the large number of genetic anomalies present in most cancers, it has been difficult to evaluate the extent ...
- Tissue-specific role of glycogen synthase kinase 3 beta in glucose homeostasis and insulin action
[作者:Patel, S; Doble, BW; MacAulay, K; Sinclair, EM; Drucker, DJ; Woodgett, JR,期刊:Molecular and Cellular Biology, 页码:6314-6328 , 文章类型: Article,,卷期:2008年28-20]
- Dysregulation of the protein kinase glycogen synthase kinase 3 (GSK-3) has been implicated in the development of type 2 diabetes mellitus. GSK-3 protein expression and kinase activity are elevated in diabetes, while sele...
- Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells
[作者:Card, DAG; Hebbar, PB; Li, LP; Trotter, KW; Komatsu, Y; Mishina, Y; Archer, TK,期刊:Molecular and Cellular Biology, 页码:6426-6438 , 文章类型: Article,,卷期:2008年28-20]
- Oct4 and Sox2 are transcription factors required for pluripotency during early embryogenesis and for the maintenance of embryonic stem cell (ESC) identity. Functional mechanisms contributing to pluripotency are expected ...
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