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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共38条记录   Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice [作者：Yang, ES; Wang, H; Jiang, GC; Nowsheen, S; Fu, A; Hallahan, DE; Xia, F,期刊：Journal of clinical investigation, 页码：1124-1135 , 文章类型： Article，,卷期：2009年119-5] Long-term neurological deficiencies resulting from hippocampal cytotoxicity induced by cranial irradiation (IR) present a challenge in the treatment of primary and metastatic brain cancers, especially in children. Previo... Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39 [作者：Hyman, MC; Petrovic-Djergovic, D; Visovatti, SH; Liao, H; Yanamadala, S; Bouis, D; Su, EMJ; Lawrence, DA; Broekman, MJ; Marcus, AJ; Pinsky, DJ,期刊：Journal of clinical investigation, 页码：1136-1149 , 文章类型： Article，,卷期：2009年119-5] Leukocyte and platelet accumulation at sites of cerebral ischemia exacerbate cerebral damage. The ectoenzyme CD39 on the plasmalemma of endothelial cells metabolizes ADP to suppress platelet accumulation in the ischemic ... Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats [作者：Novak, KR; Nardelli, P; Cope, TC; Filatov, G; Glass, JD; Khan, J; Rich, MM,期刊：Journal of clinical investigation, 页码：1150-1158 , 文章类型： Article，,卷期：2009年119-5] Neuropathy and myopathy can cause weakness during critical illness. To determine whether reduced excitability of peripheral nerves, rather than degeneration, is the mechanism underlying acute neuropathy in critically ill... HIF-2 alpha, but not HIF-1 alpha, promotes iron absorption in mice [作者：Mastrogiannaki, M; Matak, P; Keith, B; Simon, MC; Vaulont, S; Peyssonnaux, C,期刊：Journal of clinical investigation, 页码：1159-1166 , 文章类型： Article，,卷期：2009年119-5] HIF transcription factors (HIF-1 and HIF-2) are central mediators of cellular adaptation to hypoxia. Because the resting partial pressure of oxygen is low in the intestinal lumen, epithelial cells are believed to be mild... Anti-TNF immunotherapy reduces CD8(+) T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans [作者：Bruns, H; Meinken, C; Schauenberg, P; Harter, G; Kern, P; Modlin, RL; Antoni, C; Stenger, S,期刊：Journal of clinical investigation, 页码：1167-1177 , 文章类型： Article，,卷期：2009年119-5] The incidence of tuberculosis is increased during treatment of autoimmune diseases with anti-TNF antibodies. This is a significant clinical complication, but also provides a unique model to study immune mechanisms in hum... Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression [作者：Papeta, N; Chan, KT; Prakash, S; Martino, J; Kiryluk, K; Ballard, D; Bruggeman, LA; Frankel, R; Zheng, ZY; Klotman, PE; Zhao, HY; D'Agati, VD; Lifton, RP; Gharavi, AG,期刊：Journal of clinical investigation, 页码：1178-1188 , 文章类型： Article，,卷期：2009年119-5] Multiple studies have linked podocyte gene variants to diverse sporadic nephropathies, including HIV-1-associated nephropathy (HIVAN). We previously used linkage analysis to identify a major HIVAN susceptibility locus in... Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process [作者：Choi, JY; Khansaheb, M; Joo, NS; Krouse, ME; Robbins, RC; Weill, D; Wine, JJ,期刊：Journal of clinical investigation, 页码：1189-1200 , 文章类型： Article，,卷期：2009年119-5] Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF). Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by sensory neurons that release substanc... GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice [作者：Kammoun, HL; Chabanon, H; Hainault, I; Luquet, S; Magnan, C; Koike, T; Ferre, P; Foufelle, F,期刊：Journal of clinical investigation, 页码：1201-1215 , 文章类型： Article，,卷期：2009年119-5] Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the transcription factor SREBP-1c. Despite prev... Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [作者：Qing, J; Du, XN; Chen, YM; Chan, P; Li, H; Wu, P; Marsters, S; Stawicki, S; Tien, J; Totpal, K; Ross, S; Stinson, S; Dornan, D; French, D; Wang, QR; Stephan, JP; Wu, Y; Wiesmann, C; Ashkenazi, A,期刊：Journal of clinical investigation, 页码：1216-1229 , 文章类型： Article，,卷期：2009年119-5] Overexpression of FGF receptor 3 (FGFR3) is implicated in the development of t(4;14)-positive multiple myeloma. While FGFR3 is frequently overexpressed and/or activated through mutations in bladder cancer, the functional... Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice [作者：Ling, HY; Zhang, T; Pereira, L; Means, CK; Cheng, HQ; Gu, YS; Dalton, ND; Peterson, KL; Chen, J; Bers, D; Brown, JH,期刊：Journal of clinical investigation, 页码：1230-1240 , 文章类型： Article，,卷期：2009年119-5] Ca2+/calmodulin-dependent kinase II (CaMKII) has been implicated in cardiac hypertrophy and heart failure. We generated mice in which the predominant cardiac isoform, CaMKII delta, was genetically deleted (KO mice), and ... Cd1d-dependent regulation of bacterial colonization in the intestine of mice [作者：Nieuwenhuis, EES; Matsumoto, T; Lindenbergh, D; Willemsen, R; Kaser, A; Simons-Oosterhuis, Y; Brugman, S; Yamaguchi, K; Ishikawa, H; Aiba, Y; Koga, Y; Samsom, JN; Oshima, K; Kikuchi, M; Escher, JC; Hattori, M; Onderdonk, AB; Blumberg, RS,期刊：Journal of clinical investigation, 页码：1241-1250 , 文章类型： Article，,卷期：2009年119-5] The accumulation of certain species of bacteria in the intestine is involved in both tissue homeostasis and immune-mediated pathologies. The host mechanisms involved in controlling intestinal colonization with commensal ... NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo [作者：Lakshmikanth, T; Burke, S; Ali, TH; Kimpfler, S; Ursini, F; Ruggeri, L; Capanni, M; Umansky, V; Paschen, A; Sucker, A; Pende, D; Groh, V; Biassoni, R; Hoglund, P; Kato, M; Shibuya, K; Schadendorf, D; Anichini, A; Ferrone, S; Velardi, A; Karre, K; Shibuya, A; Carbone, E; Colucci, F,期刊：Journal of clinical investigation, 页码：1251-1263 , 文章类型： Article，,卷期：2009年119-5] NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be determined what specific molecular interactions are involved and whe... Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells [作者：Bao, LH; Haas, M; Pippin, J; Wang, Y; Miwa, T; Chang, A; Minto, AW; Petkova, M; Qiao, GL; Song, WC; Alpers, CE; Zhang, J; Shankland, SJ; Quigg, RJ,期刊：Journal of clinical investigation, 页码：1264-1274 , 文章类型： Article，,卷期：2009年119-5] Heritable and acquired diseases of podocytes can result in focal and segmental glomerulosclerosis (FSGS). We modeled FSGS by passively transferring mouse podocyte-specific sheep Abs into BALB/c mice. BALB/c mice deficien... Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models [作者：Brooks, C; Wei, Q; Cho, SG; Dong, Z,期刊：Journal of clinical investigation, 页码：1275-1285 , 文章类型： Article，,卷期：2009年119-5] The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during acute kidney injury, remains largely unknown. Here, we have demonstrated a striking morphological change of mitochondria in expe... Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury [作者：Heymann, F; Meyer-Schwesinger, C; Hamilton-Williams, EE; Hammerich, L; Panzer, U; Kaden, S; Quaggin, SE; Floege, J; Grone, HJ; Kurts, C,期刊：Journal of clinical investigation, 页码：1286-1297 , 文章类型： Article，,卷期：2009年119-5] The progression of kidney disease to renal failure correlates with infiltration of mononuclear immune cells into the tubulointerstitium. These infiltrates contain macrophages, DCs, and T cells, but the role of each cell ... VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats [作者：Farkas, L; Farkas, D; Ask, K; Moller, A; Gauldie, J; Margetts, P; Inman, M; Kolb, M,期刊：Journal of clinical investigation, 页码：1298-1311 , 文章类型： Article，,卷期：2009年119-5] Idiopathic pulmonary fibrosis (IPF) can lead to the development of secondary pulmonary hypertension (PH) and ultimately death. Despite this known association, the precise mechanism of disease remains unknown. Using a rat...