- Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart
[作者：Zhou, B; Ma, Q; Kong, SW; Hu, YW; Campbell, PH; McGowan, FX; Ackerman, KG; Wu, BR; Zhou, B; Tevosian, SG; Pu, WT,期刊：Journal of clinical investigation, 页码：1462-1476 , 文章类型： Article，,卷期：2009年119-6]
- Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of heart disease. While the transcriptional regulator friend of Gata 2 (FOG2) is known to be essential for heart morp...
- Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD(2) biosynthesis
[作者：Tokudome, S; Sano, M; Shinmura, K; Matsuhashi, T; Morizane, S; Moriyama, H; Tamaki, K; Hayashida, K; Nakanishi, H; Yoshikawa, N; Shimizu, N; Endo, J; Katayama, T; Murata, M; Yuasa, S; Kaneda, R; Tomita, K; Eguchi, N; Urade, Y; Asano, K; Utsunomiya, Y; Suzuki, T; Taguchi, R; Tanaka, H; Fukuda, K,期刊：Journal of clinical investigation, 页码：1477-1488 , 文章类型： Article，,卷期：2009年119-6]
Lipocalin-type prostaglandin D synthase (L-PGDS), which was originally identified as an enzyme responsible for PGD(2) biosynthesis in the brain, is highly expressed in the myocardium, including in cardiomyocytes. Howe...
- TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans
[作者：Washington, AV; Gibot, S; Acevedo, I; Gattis, J; Quigley, L; Feltz, R; De La Mota, A; Schubert, RL; Gomez-Rodriguez, J; Cheng, J; Dutra, A; Pak, E; Chertov, O; Rivera, L; Morales, J; Lubkowski, J; Hunter, R; Schwartzberg, PL; McVicar, DW,期刊：Journal of clinical investigation, 页码：1489-1501 , 文章类型： Article，,卷期：2009年119-6]
- Triggering receptor expressed on myeloid cells-like (TREM-like) transcript-1 (TLT-1), a type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte a-granules, relocates to the platelet surface upon pl...
- A partial form of recessive STAT1 deficiency in humans
[作者：Chapgier, A; Kong, XF; Boisson-Dupuis, S; Jouanguy, E; Averbuch, D; Feinberg, J; Zhang, SY; Bustamante, J; Vogt, G; Lejeune, J; Mayola, E; de Beaucoudrey, L; Abel, L; Engelhard, D; Casanova, JL,期刊：Journal of clinical investigation, 页码：1502-1514 , 文章类型： Article，,卷期：2009年119-6]
- Complete STAT1 deficiency is an autosomal recessive primary immunodeficiency caused by null mutations that abolish STAT1-dependent cellular responses to both IFN-alpha/beta and IFN-gamma. Affected children suffer from le...
- V alpha 24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages
[作者：Song, LP; Asgharzadeh, S; Salo, J; Engell, K; Wu, HW; Sposto, R; Ara, T; Silverman, AM; DeClerck, YA; Seeger, RC; Metelitsa, LS,期刊：Journal of clinical investigation, 页码：1524-1536 , 文章类型： Article，,卷期：2009年119-6]
- Tumor infiltration with V alpha 24-invariant NKT cells (NKTs) associates with favorable outcome in neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d(+) cells, the majority of human tum...
- Foxa1 and Foxa2 regulate bile duct development in mice
[作者：Li, ZY; White, P; Tuteja, G; Rubins, N; Sackett, S; Kaestner, KH,期刊：Journal of clinical investigation, 页码：1537-1545 , 文章类型： Article，,卷期：2009年119-6]
- The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental competence of the foregut endoderm and in initiating liver specification. Using condit...
- Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine
[作者：Hanczko, R; Fernandez, DR; Doherty, E; Qian, YM; Vas, G; Niland, B; Telarico, T; Garba, A; Banerjee, S; Middleton, FA; Barrett, D; Barcza, M; Banki, K; Landas, SK; Perl, A,期刊：Journal of clinical investigation, 页码：1546-1557 , 文章类型： Article，,卷期：2009年119-6]
- Although oxidative stress has been implicated in acute acetaminophen-induced liver failure and in chronic liver cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic pathway has been identified. Re...
- JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma
[作者：Durbin, AD; Somers, GR; Forrester, M; Pienkowska, M; Hannigan, GE; Malkin, D,期刊：Journal of clinical investigation, 页码：1558-1570 , 文章类型： Article，,卷期：2009年119-6]
- Although most reports describe the protein kinase integrin-linked kinase (ILK) as a proto-oncogene, occasional studies detail opposing functions in the regulation of normal and transformed cell proliferation, differentia...
- Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer
[作者：Bierie, B; Chung, CH; Parker, JS; Stover, DG; Cheng, N; Chytil, A; Aakre, M; Shyr, Y; Moses, HL,期刊：Journal of clinical investigation, 页码：1571-1582 , 文章类型： Article，,卷期：2009年119-6]
- In human breast cancer, loss of carcinoma cell-specific response to TGF-beta signaling has been linked to poor patient prognosis. However, the mechanisms through which TGF-beta regulates these processes remain largely un...
- Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta
[作者：Vetrone, SA; Montecino-Rodriguez, E; Kudryashova, E; Kramerova, I; Hoffman, EP; Liu, SD; Miceli, MC; Spencer, MJ,期刊：Journal of clinical investigation, 页码：1583-1594 , 文章类型： Article，,卷期：2009年119-6]
- Duchenne muscular dystrophy (DMD) is an X-linked, degenerative muscle disease that is exacerbated by secondary inflammation. Here, we characterized the immunological milieu of dystrophic muscle in mdx mice, a model of DM...
- Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia
[作者：Kurian, MA; Zhen, J; Cheng, SY; Li, Y; Mordekar, SR; Jardine, P; Morgan, NV; Meyer, E; Tee, L; Pasha, S; Wassmer, E; Heales, SJR; Gissen, P; Reith, MEA; Maher, ER,期刊：Journal of clinical investigation, 页码：1595-1603 , 文章类型： Article，,卷期：2009年119-6]
- Genetic variants of the SLC6A3 gene that encodes the human dopamine transporter (DAT) have been linked to a variety of neuropsychiatric disorders, particularly attention deficit hyperactivity disorder. In addition, the h...
- CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells
[作者：Wang, YH; Gangeswaran, R; Zhao, XB; Wang, PJ; Tysome, J; Bhakta, V; Yuan, M; Chikkanna-Gowda, CP; Jiang, GZ; Gao, DL; Cao, FY; Francis, J; Yu, JX; Liu, KD; Yang, HY; Zhang, YH; Zang, WD; Chelala, C; Dong, ZM; Lemoine, N,期刊：Journal of clinical investigation, 页码：1604-1615 , 文章类型： Article，,卷期：2009年119-6]
- The changes in cancer cell surface molecules and intracellular signaling pathways during tumorigenesis make delivery of adenovirus-based cancer therapies inefficient. Here we have identified carcinoembryonic antigen-rela...
- The growth factor midkine regulates the renin-angiotensin system in mice
[作者：Hobo, A; Yuzawa, Y; Kosugi, T; Kato, N; Asai, N; Sato, W; Maruyama, S; Ito, Y; Kobori, H; Ikematsu, S; Nishiyama, A; Matsuo, S; Kadomatsu, K,期刊：Journal of clinical investigation, 页码：1616-1625 , 文章类型： Article，,卷期：2009年119-6]
- The renin-angiotensin system plays a pivotal role in regulating blood pressure and is involved in the pathogenesis of kidney disorders and other diseases. Here, we report that the growth factor midkine is what we believe...
- Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
[作者：Korf, H; Vander Beken, S; Romano, M; Steffensen, KR; Stijlemans, B; Gustafsson, JA; Grooten, J; Huygen, K,期刊：Journal of clinical investigation, 页码：1626-1637 , 文章类型： Article，,卷期：2009年119-6]
- Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. However, exactly how LXRs modulate inflammation during infection re...
- Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models
[作者：Orihuela, CJ; Mahdavi, J; Thornton, J; Mann, B; Wooldridge, KG; Abouseada, N; Oldfield, NJ; Self, T; Ala'Aldeen, DAA; Tuomaneni, EI,期刊：Journal of clinical investigation, 页码：1638-1646 , 文章类型： Article，,卷期：2009年119-6]
- A diverse array of infectious agents, including prions and certain neurotropic viruses, bind to the laminin receptor (LR), and this determines tropism to the CNS. Bacterial meningitis in childhood is almost exclusively c...
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