- Predicting response to hepatitis C therapy
[作者：Oh, TS; Rice, CM,期刊：Journal of clinical investigation, 页码：5-7 , 文章类型： Editorial Material，,卷期：2009年119-1]
- Current treatment for chronic hepatitis C is expensive, is often accompanied by burdensome side effects, and, sadly, fails in almost half of cases. The ability to predict such failures prior to treatment could save a gre...
- Deciphering migraine
[作者：Takano, T; Nedergaard, M,期刊：Journal of clinical investigation, 页码：16-19 , 文章类型： Editorial Material，,卷期：2009年119-1]
- Migraine is an episodic headache disorder affecting as many as 10% of people worldwide. Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of severe migraine accompanied by visual disturbances known as a...
- Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
[作者：Bournazou, I; Pound, JD; Duffin, R; Bournazos, S; Melville, LA; Brown, SB; Rossi, AG; Gregory, CD,期刊：Journal of clinical investigation, 页码：20-32 , 文章类型： Article，,卷期：2009年119-1]
- Apoptosis is a noninflammatory, programmed form of cell death. One mechanism underlying the non-phlogistic nature of the apoptosis program is the swift phagocytosis of the dying cells. How apoptotic cells attract mononuc...
- TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4
[作者：Ito, T; Schaller, M; Hogaboam, CM; Standiford, TJ; Sandor, M; Lukacs, NW; Chensue, SW; Kunkel, SL,期刊：Journal of clinical investigation, 页码：33-46 , 文章类型： Article，,卷期：2009年119-1]
- TLR9 activation is important for the maintenance of mycobacteria-elicited pulmonary granulomatous responses, hallmarks of protective immune responses following mycobacterial infection. However, the mechanism or mechanism...
- IL-21 R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice
[作者：Jin, H; Oyoshi, MK; Le, Y; Bianchi, T; Koduru, S; Mathias, CB; Kumar, L; Le Bras, S; Young, D; Collins, M; Grusby, MJ; Wenzel, J; Bieber, T; Boes, M; Silberstein, LE; Oettgen, HC; Geha, RS,期刊：Journal of clinical investigation, 页码：47-60 , 文章类型： Article，,卷期：2009年119-1]
- Atopic dermatitis (AD) is a common allergic inflammatory skin disease caused by a combination of intense pruritus, scratching, and epicutaneous (e.c.) sensitization with allergens. To explore the roles of IL-21 and IL-21...
- IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
[作者：Haak, S; Croxford, AL; Kreymborg, K; Heppner, FL; Pouly, S; Becher, B; Waisman, A,期刊：Journal of clinical investigation, 页码：61-69 , 文章类型： Article，,卷期：2009年119-1]
- The clear association of Th17 cells with autoimmune pathogenicity implicates Th17 cytokines as critical mediators of chronic autoimmune diseases such as EAE. To study the impact of IL-17A on CNS inflammation, we generate...
- Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
[作者：Romeo, S; Yin, W; Kozlitina, J; Pennacchio, LA; Boerwinkle, E; Hobbs, HH; Cohen, JC,期刊：Journal of clinical investigation, 页码：70-79 , 文章类型： Article，,卷期：2009年119-1]
- The relative activity of lipoprotein lipase (LPL) in different tissues controls the partitioning of lipoprotein-derived fatty acids between sites of fat storage (adipose tissue) and oxidation (heart and skeletal muscle)....
- Expression of an activating mutation in the gene encoding the K-ATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes
[作者：Girard, CA; Wunderlich, FT; Shimomura, K; Collins, S; Kaizik, S; Proks, P; Abdulkader, F; Clark, A; Ball, V; Zubcevic, L; Bentley, L; Clark, R; Church, C; Hugill, A; Galvanovskis, J; Cox, R; Rorsman, P; Bruning, JC; Ashcroft, FM,期刊：Journal of clinical investigation, 页码：80-90 , 文章类型： Article，,卷期：2009年119-1]
- Neonatal diabetes is a rare monogenic form of diabetes that usually presents within the first six months of life. It is commonly caused by gain-of-function mutations in the genes encoding the Kir6.2 and SUR1 subunits of ...
- A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining
[作者：van der Burg, M; IJspeert, H; Verkaik, NS; Turul, T; Wiegant, WW; Morotomi-Yano, K; Mari, PO; Tezcan, I; Chen, DJ; Zdzienicka, MZ; van Dongen, JJM; van Gent, DC,期刊：Journal of clinical investigation, 页码：91-98 , 文章类型： Article，,卷期：2009年119-1]
- Radiosensitive T-B- severe combined immunodeficiency (RS-SCID) is caused by defects in the nonhomologous end-joining (NHEJ) DNA repair pathway, which results in failure of functional V(D)J recombination. Here we have ide...
- Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1
[作者：Eikermann-Haerter, K; Dilekoz, E; Kudo, C; Savitz, SI; Waeber, C; Baum, MJ; Ferrari, MD; van den Maagdenberg, AMJM; Moskowitz, MA; Ayata, C,期刊：Journal of clinical investigation, 页码：99-109 , 文章类型： Article，,卷期：2009年119-1]
- Familial hemiplegic migraine type 1 (FHM1) is an autosomal dominant subtype of migraine with aura that is associated with hemiparesis. As with other types of migraine, it affects women more frequently than men. FHM1 is c...
- PPAR gamma in the endothelium regulates metabolic responses to high-fat diet in mice
[作者：Kanda, T; Brown, JD; Orasanu, G; Vogel, S; Gonzalez, FJ; Sartoretto, J; Michel, T; Plutzky, J,期刊：Journal of clinical investigation, 页码：110-124 , 文章类型： Article，,卷期：2009年119-1]
- Although endothelial dysfunction, defined as abnormal vasoreactivity, is a common early finding in individuals with type 2 diabetes, the endothelium has not been known to regulate metabolism. As PPAR gamma, a transcripti...
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