- Ligation of TLR9 induced on human IL-10-secreting Tregs by 1 alpha,25-dihydroxyvitamin D3 abrogates regulatory function
[作者：Urry, Z; Xystrakis, E; Richards, DF; McDonald, J; Sattar, Z; Cousins, DJ; Corrigan, CJ; Hickman, E; Brown, Z; Hawrylowicz, CM,期刊：Journal of clinical investigation, 页码：387-398 , 文章类型： Article，,卷期：2009年119-2]
- Signaling through the TLR family of molecular pattern recognition receptors has been implicated in the induction of innate and adaptive immune responses. A role for TLR signaling in the maintenance and/or regulation of T...
- PKC alpha regulates platelet granule secretion and thrombus formation in mice
[作者：Konopatskaya, O; Gilio, K; Harper, MT; Zhao, Y; Cosemans, JMEM; Karim, ZA; Whiteheart, SW; Molkentin, JD; Verkade, P; Watson, SP; Heemskerk, JWM; Poole, AW,期刊：Journal of clinical investigation, 页码：399-407 , 文章类型： Article，,卷期：2009年119-2]
- Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members...
- Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
[作者：Takimoto, E; Koitabashi, N; Hsu, S; Ketner, EA; Zhang, M; Nagayarna, T; Bedja, D; Gabrielson, KL; Blanton, R; Siderovski, DP; Mendelsohn, ME; Kass, DA,期刊：Journal of clinical investigation, 页码：408-420 , 文章类型： Article，,卷期：2009年119-2]
- The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. G(q) protein-coupled receptor pathways become activated and can ...
- Loss of PIP5KI gamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes (vol 119, pg 421, 2009)
[作者：Wang, YF; Litvinov, RI; Chen, XS; Bach, TL; Lian, LR; Petrich, BG; Monkley, SJ; Kanaho, Y; Critchley, DR; Sasaki, T; Birnbaum, MJ; Weisel, JW; Hartwig, J; Abrams, CS,期刊：Journal of clinical investigation, 页码：421-421 , 文章类型： Correction，,卷期：2009年119-2]
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- Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake (vol 119, pg 421, 2009)
[作者：Loeffler, M; Kruger, JA; Niethammer, AG; Reisfeld, RA,期刊：Journal of clinical investigation, 页码：421-421 , 文章类型： Correction，,卷期：2009年119-2]
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- Endogenous prolactin-releasing peptide regulates food intake in rodents (vol 119, pg 422, 2009)
[作者：Takayanagi, Y; Matsumoto, H; Nakara, M; Mera, T; Fukusumi, S; Hinuma, S; Ueta, Y; Yada, T; Leng, G; Onaka, T,期刊：Journal of clinical investigation, 页码：422-422 , 文章类型： Correction，,卷期：2009年119-2]
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- DAMPs ramp up drug toxicity
[作者：Maher, JJ,期刊：Journal of clinical investigation, 页码：246-249 , 文章类型： Editorial Material，,卷期：2009年119-2]
- The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of the JCI, Imaeda and c...
- Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling
[作者：Pylayeva, Y; Gillen, KM; Gerald, W; Beggs, HE; Reichardt, LF; Giancotti, FG,期刊：Journal of clinical investigation, 页码：252-266 , 文章类型： Article，,卷期：2009年119-2]
- Cancer cells require sustained oncogenic signaling in order to maintain their malignant properties. It is, however, unclear whether they possess other dependencies that can be exploited therapeutically. We report here th...
- Immune cell-derived opioids protect against neuropathic pain in mice
[作者：Labuz, D; Schmidt, Y; Schreiter, A; Rittner, HL; Mousa, SA; Machelska, H,期刊：Journal of clinical investigation, 页码：278-286 , 文章类型： Article，,卷期：2009年119-2]
- The analgesic effects of leakocyte-derived opioids have been exclusively demonstrated for somatic inflammatory pain, for example, the pain associated with surgery and arthritis. Neuropathic pain results from injury to ne...
- COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice
[作者：Vardeh, D; Wang, DR; Costigan, M; Lazarus, M; Saper, CB; Woolf, CJ; FitzGerald, GA; Samad, TA,期刊：Journal of clinical investigation, 页码：287-294 , 文章类型： Article，,卷期：2009年119-2]
- A cardinal feature of peripheral inflammation is pain. The most common way of managing inflammatory pain is to use nonsteroidal antiinflammatory agents (NSAIDs) that reduce prostanoid production, for example, selective i...
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