- Alendronate Inhibits Growth of High-grade Chondrosarcoma Cells
[作者:Susa, M; Morii, T; Yabe, H; Horiuchi, K; Toyama, Y; Weissbach, L; Hornicek, FJ; Morioka, H,期刊:Anticancer Research, 页码:1879-1888 , 文章类型: Article,,卷期:2009年29-6]
- Background: Conventional chemotherapy is ineffective for high-grade chondrosarcomas, highlighting the need for improved chemotherapies. Various clinical trials have been initiated using antiapoptotic agents and perifosin...
- Atrial Natriuretic Peptide and Long-acting Natriuretic Peptide Inhibit Ras in Human Prostate Cancer Cells
[作者:Sun, Y; Eichelbaum, EJ; Lenz, A; Skelton, WP; Wang, H; Vesely, DL,期刊:Anticancer Research, 页码:1889-1893 , 文章类型: Article,,卷期:2009年29-6]
- Background: Atrial natriuretic peptide and long-acting natriuretic peptide have anticancer effects in human prostate adenocarcinoma. Materials and Methods: The effects of atrial natriuretic peptide and long-acting natriu...
- Differentially Regulated Genes in MEN1-transfected BON Cells Using RT-differential Display and Oligonucleotide Microarrays
[作者:Lopez-Egido, JR; Wang, Y; Gronberg, M; Grimfjard, P; Wang, S; Stalberg, P; Skogseid, B,期刊:Anticancer Research, 页码:1859-1866 , 文章类型: Article,,卷期:2009年29-6]
- Background: Apart from inactivation of the MEN1 gene, the molecular mechanisms involved in tumorigenesis of the endocrine organs and MEN1-associated non-endocrine lesions remain unknown. Materials and Methods: In order t...
- Combination of PI3K/mTOR Inhibition Demonstrates Efficacy in Human Chordoma
[作者:Schwab, J; Antonescu, C; Boland, P; Healey, J; Rosenberg, A; Nielsen, P; Iafrate, J; Delaney, T; Yoon, S; Choy, E; Harmon, D; Raskin, K; Yang, C; Mankin, H; Springfield, D; Hornicek, F; Duan, ZF,期刊:Anticancer Research, 页码:1867-1871 , 文章类型: Article,,卷期:2009年29-6]
- Background: Chordomas are rare tumors of the axial skeleton for which surgical resection remains the most reliable means of cure. PI-103 is a inhibitor of PI3K/AKT and mTOR activation. This study aims to determine whethe...
- Efficacy of a Genetically-modified Salmonella typhimurium in an Orthotopic Human Pancreatic Cancer in Nude Mice
[作者:Nagakura, C; Hayashi, K; Zhao, M; Yamauchi, K; Yamamoto, N; Tsuchiya, H; Tomita, K; Bouvet, M; Hoffman, RM,期刊:Anticancer Research, 页码:1873-1878 , 文章类型: Article,,卷期:2009年29-6]
- We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires the amino acids arginine and leuci...
- Osteopontin Modulates Malignant Pleural Mesothelioma Cell Functions In Vitro
[作者:Ohashi, R; Tajima, K; Takahashi, F; Cui, R; Gu, T; Shimizu, K; Nishio, K; Fukuoka, K; Nakano, T; Takahashi, K,期刊:Anticancer Research, 页码:2205-2214 , 文章类型: Article,,卷期:2009年29-6]
- Background: Although serum osteopontin (OPN) concentration is elevated in patients with malignant pleural mesothelioma (MPM), the role of OPN in the pathogenesis and development of MPM remains unknown. Materials and Meth...
- Demethylation of the CDH3 Gene Is Frequently Detected in Advanced Colorectal Cancer
[作者:Hibi, K; Goto, T; Mizukami, H; Kitamura, YH; Sakuraba, K; Sakata, M; Saito, M; Ishibashi, K; Kigawa, G; Nemoto, H; Sanada, Y,期刊:Anticancer Research, 页码:2215-2217 , 文章类型: Article,,卷期:2009年29-6]
- Background: Recently, it has been proven that the CDH3 promoter was hypomethylated in colonic aberrant foci and colorectal cancer. The hypomethylation was also associated with induction of CDH3 expression in colorectal c...
- Expression of Bone Morphogenetic Proteins in Giant Cell Tumor of Bone
[作者:Kudo, N; Ogose, A; Ariizumi, T; Kawashima, H; Hotta, T; Hatano, H; Morita, T; Nagata, M; Siki, Y; Kawai, A; Hotta, Y; Hoshino, M; Endo, N,期刊:Anticancer Research, 页码:2219-2225 , 文章类型: Article,,卷期:2009年29-6]
- Background: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence. A characteristic pattern of peripheral bone formation has been described in GCT recurrence in soft tissue...
- Determination of Minimum Effective Dose and Optimal Dosing Schedule for Liposomal Curcumin in a Xenograft Human Pancreatic Cancer Model
[作者:Mach, CM; Mathew, L; Mosley, SA; Kurzrock, R; Smith, JA,期刊:Anticancer Research, 页码:1895-1899 , 文章类型: Article,,卷期:2009年29-6]
- Background: Curcumin is a food chemical present in tumeric (Curcuma longa) that has pharmacological activity to suppress carcinogenesis and inhibits multiple signaling pathways such as nuclear factor kappaB (NF-kappa B),...
- Cleavage of the Ewing Tumour-specific EWSR1-FLI1 mRNA by Hammerhead Ribozymes
[作者:Huhn, R; Staege, MS; Hesse, M; Liebig, B; Burdach, SEG,期刊:Anticancer Research, 页码:1901-1908 , 文章类型: Article,,卷期:2009年29-6]
- Background: Ewing family tumours (EFT) are the second most common bone tumours in children and adolescents. In the majority of EFT, EWSR1-FLI1 (Ewing sarcoma breakpoint region 1-Friend leukaemia virus integration 1) fusi...
- 5-Hydroxymethylfurfural and 5-Sulfooxymethylfurfural Increase Adenoma and Flat ACF Number in the Intestine of Min/ plus Mice
[作者:Svendsen, C; Husoy, T; Glatt, H; Paulsen, JE; Alexander, J,期刊:Anticancer Research, 页码:1921-1926 , 文章类型: Article,,卷期:2009年29-6]
- Background: 5-Hydroxymethylfurfural (HMF) is produced in large quantities during the processing of food containing carbohydrates and can be metabolised to 5-sulfooxymethylfurfural (SMF), a reactive intermediate that can ...
- Conversion from Calcineurin Inhibitors to Sirolimus Reduces Vascularization and Thickness of Post-transplant Cutaneous Squamous Cell Carcinomas
[作者:Rival-Tringali, AL; Euvrard, S; Decullier, E; Claudy, A; Faure, M; Kanitakis, J,期刊:Anticancer Research, 页码:1927-1932 , 文章类型: Article,,卷期:2009年29-6]
- Background: Immunosuppression favors the development of skin cancer. Experimental data suggest that sirolimus (SRL) has antitumoral and antiangiogenic properties. An investigation was undertaken into the effects of SRL o...
- Spontaneous Regression of Human Cancer Cells In Vitro: Potential Role of Disruption of Cdk1/Cdk4 Co-expression
[作者:Warenius, H; Kyritsi, L; Grierson, I; Howarth, A; Seabra, L; Jones, M; Thomas, C; Browning, P; White, R,期刊:Anticancer Research, 页码:1933-1941 , 文章类型: Article,,卷期:2009年29-6]
- Background: Although well-acknowledged in vivo, spontaneous death of cancer cells in vitro is less widely appreciated. Materials and Methods: Colony formation was studied in untreated control plates of standard clonogeni...
- Establishment and Characterization of Three Novel Cell Lines - P-STS, L-STS, H-STS - Derived from a Human Metastatic Midgut Carcinoid
[作者:Pfragner, R; Behmel, A; Hoger, H; Beham, A; Ingolic, E; Stelzer, I; Svejda, B; Moser, VA; Obenauf, AC; Siegl, V; Haas, O; Niederle, B,期刊:Anticancer Research, 页码:1951-1961 , 文章类型: Article,,卷期:2009年29-6]
- Carcinoids are rare tumors derived from enterochromaffin (EC) cells of the embryonic neural crest. They have malignant potential and their incidence is steadily increasing. The only curative treatment option is surgery. ...
- A Novel lodomethylene-dimethyl-dihydropyranone Induces G(2)/M Arrest and Apoptosis in Human Cancer Cells
[作者:Bignon, J; Benechie, M; Herlem, D; Liu, JM; Pinault, A; Khuong-Huu, F; Wdzieczak-Bakala, J,期刊:Anticancer Research, 页码:1963-1969 , 文章类型: Article,,卷期:2009年29-6]
- Background: The putative pharmacophore of a naturally cytotoxic limonoid haperforin B1, E-5-iodomethylene-6,6-dimethyl-5,6-dihydropyran-2-one (IDDP) was synthesized and its biological activity was investigated. Materials...
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