Despite important innovations in the pharmacotherapy of schizophrenia in the last few decades, most notably the introduction of a number of dual-acting dopamine D2/5-HT2A antagonists, there remains a need for more eff...

MGCD-0103 is an orally active isoform-selective histone deacetylase (HDAC) inhibitor under development by MethylGene in cooperation with Pharmion. Histone acetylation represents an attractive target in cancer therapy ...

Plants have been one of the major sources of medicines since the dawn of human civilization. The contribution of plant-derived drugs in modern times is still significant and much interest has been focused on exploitin...

Tetrahydrofolate is derived from folate and serves as a backbone for single-carbon transfer reactions. The donation of one-carbon units, such as methyl and methylene, is crucial for nucleotide synthesis and consequent...

The mGluR(5) subtype of metabotropic glutamate receptor (mGluR) plays an important role in the modulation of neuronal excitability and synaptic transmission in a number of brain circuits. These slow synaptic responses...

Recently, extensive research has been done in the area of bio-oncology. Bio-oncology focuses on four targets in particular: angiogenesis, signal transduction, B-cell biology and apoptosis. Monoclonal antibodies (mAbs)...

Chronic obstructive pulmonary disease (COPD) is a common, chronic inflammatory lung disease associated with progressive airflow obstruction. It has become apparent that, unlike asthma, antiinflammatory therapies are i...

Currently available anticoagulants include heparin, low-molecular-weight heparin, fondaparinux and warfarin. Despite advances, currently available agents have limitations that have provided the impetus for the develop...

Ceftaroline fosamil (PPI-0903, TAK-599) is a novel N-phosphono prodrug of PPI-0903M (ceftaroline, T-91825), a broad-spectrum cephalosporin antibiotic with potent activity against methicillin-resistant Staphylococcus a...

Elesclomol (STA-4783) is a small molecule that induces apoptosis via the mitochondrial apoptotic pathway in cancer cells by increasing oxidative stress, while having little or no effect on normal cells. The agent acts...