- Antineoplastic Agents. 578. Synthesis of Stilstatins 1 and 2 and Their Water-Soluble Prodrugs
[作者:Pettit, GR; Thornhill, A; Melody, N; Knight, JC,期刊:Journal of natural products, 页码:380-388 , 文章类型: Article,,卷期:2009年72-3]
- Efficient syntheses of 3,4-methylenedioxy-4',5-dimethoxy-2',3'-dihydroxy-Z-stilbene (stilstatin 1, 2), 3,4,4'-trimethoxy2',3',5-trihydroxy-Z-stilbene (stilstatin 2, 5), and respective phosphate prodrugs have been summari...
- Rapid Cloning and Heterologous Expression of the Meridamycin Biosynthetic Gene Cluster Using a Versatile Escherichia coli-Streptomyces Artificial Chromosome Vector, pSBAC
[作者:Liu, H; Jiang, H; Haltli, B; Kulowski, K; Muszynska, E; Feng, XD; Summers, M; Young, M; Graziani, E; Koehn, F; Carter, GT; He, M,期刊:Journal of natural products, 页码:389-395 , 文章类型: Article,,卷期:2009年72-3]
- Expression of biosynthetic pathways in heterologous hosts is an emerging approach to expedite production improvement and biosynthetic modification of natural products derived from microbial secondary metabolites. Herein ...
- Arenamides A-C, Cytotoxic NF kappa B Inhibitors from the Marine Actinomycete Salinispora arenicola
[作者:Asolkar, RN; Freel, KC; Jensen, PR; Fenical, W; Kondratyuk, TP; Park, EJ; Pezzuto, JM,期刊:Journal of natural products, 页码:396-402 , 文章类型: Article,,卷期:2009年72-3]
- Three new cyclohexadepsipeptides, arenamides A-C (1-3), were isolated from the fermentation broth of a marine bacterial strain identified as Salinispora arenicola. The planar structures of these compounds were assigned b...
- Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species
[作者:Cristians, S; Guerrero-Analco, JA; Perez-Vasquez, A; Palacios-Espinosa, F; Ciangherotti, C; Bye, R; Mata, R,期刊:Journal of natural products, 页码:408-413 , 文章类型: Article,,卷期:2009年72-3]
- The CH2Cl2-MeOH (1:1) extract of the leaves of Hintonia standleyana and H. latiflora caused significant decrease in blood glucose levels in both normal and streptozotozin (STZ)-induced diabetic rats when compared with ve...
- Development of Synthetic Methodology Suitable for the Radiosynthesis of Combretastatin A-1 (CA1) and Its Corresponding Prodrug CA1P
[作者:Shirali, A; Sriram, M; Hall, JJ; Nguyen, BL; Guddneppanavar, R; Hadimani, MB; Ackley, JF; Siles, R; Jelinek, CJ; Arthasery, P; Brown, RC; Murrell, VL; MeMordie, A; Sharma, S; Chaplin, DJ; Pinney, KG,期刊:Journal of natural products, 页码:414-421 , 文章类型: Article,,卷期:2009年72-3]
- Synthetic methodology has been established suitable for the preparation of combretastatin A-1 (CA1) and its corresponding phosphate prodrug salt (CA1P) in high specific activity radiolabeled form. Judicious selection of ...
- NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers
[作者:Calcul, L; Chow, R; Oliver, AG; Tenney, K; White, KN; Wood, AW; Fiorilla, C; Crews, P,期刊:Journal of natural products, 页码:443-449 , 文章类型: Article,,卷期:2009年72-3]
- The overexpression of the Mcl-1 protein in cancerous cells results in the sequestering of Bak, a key component in the regulation of normal cell apoptosis. Our investigation of the ability of marine-derived small-molecule...
- Absolute Configuration of Actinophyllic Acid As Determined through Chiroptical Data
[作者:Taniguchi, T; Martin, CL; Monde, K; Nakanishi, K; Berova, N; Overman, LE,期刊:Journal of natural products, 页码:430-432 , 文章类型: Article,,卷期:2009年72-3]
- The absolute configuration of actinophyllic acid (-)-1, an alkaloid with an unprecedented 2,3,6,7,9,13c-hexahydro-1H-1,7,8-(methanetriyloxymethano)pyrrolo[1',2':1,2]azacino[4,3-b]indole-8(5H)-carboxylic acid skeleton iso...
- Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa)
[作者:Godecke, T; Lankin, DC; Nikolic, D; Chen, SN; van Breemen, RB; Farnsworth, NR; Pauli, GF,期刊:Journal of natural products, 页码:433-437 , 文章类型: Article,,卷期:2009年72-3]
- As an extension of work on the recently discovered nitrogenous metabolites from Cimicifuga/Actaea species, three new guanidine alkaloids have been isolated and characterized from C. racemosa (syn. A. racemosa) roots. Of ...
- Inhibitors of the NF-kappa B Activation Pathway from Cryptocarya rugulosa
[作者:Meragelman, TL; Scudiero, DA; Davis, RE; Staudt, LM; McCloud, TG; Cardellina, JH; Shoemaker, RH,期刊:Journal of natural products, 页码:336-339 , 文章类型: Article,,卷期:2009年72-3]
- The nuclear factor-kappa B (NF-kappa B) signaling pathway is constitutively active in many types of cancers and is a potential therapeutic target. Using a cell-based assay for stability of inhibitor of kappa B (I kappa B...
- Genepolide, a Sesterpene gamma-Lactone with a Novel Carbon Skeleton from Mountain Wormwood (Artemisia umbelliformis)
[作者:Appendino, G; Taglialatela-Scafati, O; Romano, A; Pollastro, F; Avonto, C; Rubiolo, P,期刊:Journal of natural products, 页码:340-344 , 文章类型: Article,,卷期:2009年72-3]
- The sesterpene gamma-lactone genepolide (5) has been isolated from a Swiss horticultural variety of mountain wormwood (Artemisia umbelliformis) developed as a thujones-free alternative to native Western Alps wormwoods fo...
- Isolation, Structure, and Antibacterial Activities of Lucensimycins D-G, Discovered from Streptomyces lucensis MA7349 Using an Antisense Strategy
[作者:Singh, SB; Zink, DL; Dorso, K; Motyl, M; Salazar, O; Basilio, A; Vicente, F; Byrne, KM; Ha, S; Genilloud, O,期刊:Journal of natural products, 页码:345-352 , 文章类型: Article,,卷期:2009年72-3]
- Bacterial resistance to existing antibiotics continues to grow, necessitating the discovery of new compounds of this type. Antisense-based whole-cell target-based screening is a new and highly sensitive antibiotic discov...
- Absolute Configuration of the alpha,omega-Bifunctionalized Sphingolipid Leucettamol A from Leucetta microrhaphis by Deconvoluted Exciton Coupled CD
[作者:Dalisay, DS; Tsukamoto, S; Molinski, TF,期刊:Journal of natural products, 页码:353-359 , 文章类型: Article,,卷期:2009年72-3]
- The configuration of leucettamol A (1), a known long-chain "two-headed" sphingolipid (dimeric sphingolipid) from the marine sponge Leucetta microrhaphis, was determined by conversion to an N,N',O,O'-tetrabenzoyl derivati...
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