- Insulin teaches a new lesson in tolerance
[作者：Kay, TWH; Krishnamurthy, B; Brodnicki, TC; Mannering, SI,期刊：EMBO journal, 页码：2687-2688 , 文章类型： Editorial Material，,卷期：2009年28-18]
- The immune system must be educated to discriminate between the body's own tissues ('self') and foreign pathogenic microorganisms (non-self). This ability is acquired by T lymphocytes in the thymus (central tolerance) and...
- 36 degrees step size of proton-driven c-ring rotation in FoF1-ATP synthase
[作者：Duser, MG; Zarrabi, N; Cipriano, DJ; Ernst, S; Glick, GD; Dunn, SD; Borsch, M,期刊：EMBO journal, 页码：2689-2696 , 文章类型： Article，,卷期：2009年28-18]
- Synthesis of adenosine triphosphate ATP, the 'biological energy currency', is accomplished by FoF1-ATP synthase. In the plasma membrane of Escherichia coli, proton-driven rotation of a ring of 10 c subunits in the F-o mo...
- Cargo surface hydrophobicity is sufficient to overcome the nuclear pore complex selectivity barrier
[作者：Naim, B; Zbaida, D; Dagan, S; Kapon, R; Reich, Z,期刊：EMBO journal, 页码：2697-2705 , 文章类型： Article，,卷期：2009年28-18]
- To fulfil their function, nuclear pore complexes (NPCs) must discriminate between inert proteins and nuclear transport receptors (NTRs), admitting only the latter. This specific permeation is thought to depend on interac...
- beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling
[作者：Barthet, G; Carrat, G; Cassier, E; Barker, B; Gaven, F; Pillot, M; Framery, B; Pellissier, LP; Augier, J; Kang, DS; Claeysen, S; Reiter, E; Baneres, JL; Benovic, JL; Marin, P; Bockaert, J; Dumuis, A,期刊：EMBO journal, 页码：2706-2718 , 文章类型： Article，,卷期：2009年28-18]
- G protein-coupled receptors (GPCRs) have been found to trigger G protein-independent signalling. However, the regulation of G protein-independent pathways, especially their desensitization, is poorly characterized. Here,...
- SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
[作者：Huang, C; Han, Y; Wang, YM; Sun, XX; Yan, S; Yeh, ETH; Chen, YY; Cang, H; Li, H; Shi, GY; Cheng, JK; Tang, XM; Yi, J,期刊：EMBO journal, 页码：2748-2762 , 文章类型： Article，,卷期：2009年28-18]
- The physiological function of Sentrin/SUMO-specific proteases (SENPs) remains largely unexplored, and little is known about the regulation of SENPs themselves. Here, we show that a modest increase of reactive oxygen spec...
- ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis
[作者：Li, RF; Zhang, H; Yu, WH; Chen, YP; Gui, B; Liang, J; Wang, Y; Sun, LY; Yang, XH; Zhang, Y; Shi, L; Li, YY; Shang, YF,期刊：EMBO journal, 页码：2763-2776 , 文章类型： Article，,卷期：2009年28-18]
- Despite the importance of epidermal growth factor receptor (EGFR) in animal development and malignant transformation, surprisingly little is known about the regulation of its expression. Here, we report a novel zinc fing...
- Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
[作者：Mochida, S; Ikeo, S; Gannon, J; Hunt, T,期刊：EMBO journal, 页码：2777-2785 , 文章类型： Article，,卷期：2009年28-18]
- Entry into mitosis depends on the activity of cyclin-dependent kinases (CDKs). Conversely, exit from mitosis occurs when mitotic cyclins are degraded, thereby extinguishing CDK activity. Exit from mitosis must also requi...
- Greatwall maintains mitosis through regulation of PP2A
[作者：Vigneron, S; Brioudes, E; Burgess, A; Labbe, JC; Lorca, T; Castro, A,期刊：EMBO journal, 页码：2786-2793 , 文章类型： Article，,卷期：2009年28-18]
- Greatwall (GW) is a new kinase that has an important function in the activation and the maintenance of cyclin B-Cdc2 activity. Although the mechanism by which it induces this effect is unknown, it has been suggested that...
- Proofreading dynamics of a processive DNA polymerase
[作者：Ibarra, B; Chemla, YR; Plyasunov, S; Smith, SB; Lazaro, JM; Salas, M; Bustamante, C,期刊：EMBO journal, 页码：2794-2802 , 文章类型： Article，,卷期：2009年28-18]
- Replicative DNA polymerases present an intrinsic proofreading activity during which the DNA primer chain is transferred between the polymerization and exonuclease sites of the protein. The dynamics of this primer transfe...
- A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres
[作者：Germe, T; Miller, K; Cooper, JP,期刊：EMBO journal, 页码：2803-2811 , 文章类型： Article，,卷期：2009年28-18]
- The decatenation activity of topoisomerase II (Top2), which is widely conserved within the eukaryotic domain, is essential for chromosomal segregation in mitosis. It is less clear, however, whether Top2 performs the same...
- Thymus-specific deletion of insulin induces autoimmune diabetes
[作者：Fan, Y; Rudert, WA; Grupillo, M; He, J; Sisino, G; Trucco, M,期刊：EMBO journal, 页码：2812-2824 , 文章类型： Article，,卷期：2009年28-18]
- Insulin expression in the thymus has been implicated in regulating the negative selection of autoreactive T cells and in mediating the central immune tolerance towards pancreatic beta-cells. To further explore the functi...
- Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity
[作者：Ader, C; Schneider, R; Hornig, S; Velisetty, P; Vardanyan, V; Giller, K; Ohmert, I; Becker, S; Pongs, O; Baldus, M,期刊：EMBO journal, 页码：2825-2834 , 文章类型： Article，,卷期：2009年28-18]
- Potassium (K+)-channel gating is choreographed by a complex interplay between external stimuli, K+ concentration and lipidic environment. We combined solid-state NMR and electrophysiological experiments on a chimeric Kcs...
- The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4
[作者：Isabet, T; Montagnac, G; Regazzoni, K; Raynal, B; El Khadali, F; England, P; Franco, M; Chavrier, P; Houdusse, A; Menetrey, J,期刊：EMBO journal, 页码：2835-2845 , 文章类型： Article，,卷期：2009年28-18]
The JNK-interacting proteins, JIP3 and JIP4, are specific effectors of the small GTP-binding protein ARF6. The interaction of ARF6-GTP with the second leucine zipper (LZII) domains of JIP3/JIP4 regulates the binding o...
- Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins
[作者：Bonsor, DA; Hecht, O; Vankemmelbeke, M; Sharma, A; Krachler, AM; Housden, NG; Lilly, KJ; James, R; Moore, GR; Kleanthous, C,期刊：EMBO journal, 页码：2846-2857 , 文章类型： Article，,卷期：2009年28-18]
- The Tol system is a five-protein assembly parasitized by colicins and bacteriophages that helps stabilize the Gram-negative outer membrane (OM). We show that allosteric signalling through the six-bladed beta-propeller pr...
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