- Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics
[作者:Liu, XG; Weaver, D; Shirihai, O; Hajnoczky, G,期刊:EMBO journal, 页码:3074-3089 , 文章类型: Article,,卷期:2009年28-20]
- Visualizing mitochondrial fusion in real time, we identified two classes of fusion events in mammalian cells. In addition to complete fusion, we observed transient fusion events, wherein two mitochondria came into close ...
- Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation
[作者:Reider, A; Barker, SL; Mishra, SK; Im, YJ; Maldonado-Baez, L; Hurley, JH; Traub, LM; Wendland, B,期刊:EMBO journal, 页码:3103-3116 , 文章类型: Article,,卷期:2009年28-20]
- Internalization of diverse transmembrane cargos from the plasma membrane requires a similarly diverse array of specialized adaptors, yet only a few adaptors have been characterized. We report the identification of the mu...
- alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
[作者:Montanez, E; Wickstrom, SA; Altstatter, J; Chu, HY; Fassler, R,期刊:EMBO journal, 页码:3132-3144 , 文章类型: Article,,卷期:2009年28-20]
- During blood vessel development, vascular smooth muscle cells (vSMCs) and pericytes (PCs) are recruited to nascent vessels to stabilize them and to guide further vessel remodelling. Here, we show that loss of the focal a...
- Editing independent effects of ADARs on the miRNA/siRNA pathways
[作者:Heale, BSE; Keegan, LP; McGurk, L; Michlewski, G; Brindle, J; Stanton, CM; Caceres, JF; O'Connell, MA,期刊:EMBO journal, 页码:3145-3156 , 文章类型: Article,,卷期:2009年28-20]
- Adenosine deaminases acting on RNA (ADARs) are best known for altering the coding sequences of mRNA through RNA editing, as in the GluR-B Q/R site. ADARs have also been shown to affect RNA interference (RNAi) and microRN...
- A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiation
[作者:Thiebeauld, O; Schepetilnikov, M; Park, HS; Geldreich, A; Kobayashi, K; Keller, M; Hohn, T; Ryabova, LA,期刊:EMBO journal, 页码:3171-3184 , 文章类型: Article,,卷期:2009年28-20]
- The plant viral re-initiation factor transactivator viroplasmin (TAV) activates translation of polycistronic mRNA by a re-initiation mechanism involving translation initiation factor 3 (eIF3) and the 60S ribosomal subuni...
- Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression
[作者:Lindqvist, A; de Bruijn, M; Macurek, L; Bras, A; Mensinga, A; Bruinsma, W; Voets, O; Kranenburg, O; Medema, RH,期刊:EMBO journal, 页码:3196-3206 , 文章类型: Article,,卷期:2009年28-20]
- Activation of the DNA damage checkpoint causes a cell-cycle arrest through inhibition of cyclin-dependent kinases (cdks). To successfully recover from the arrest, a cell should somehow be maintained in its proper cell-cy...
- Ubiquitin ligase ARF-BP1/Mule modulates base excision repair
[作者:Parsons, JL; Tait, PS; Finch, D; Dianova, II; Edelmann, MJ; Khoronenkova, SV; Kessler, BM; Sharma, RA; McKenna, WG; Dianov, GL,期刊:EMBO journal, 页码:3207-3215 , 文章类型: Article,,卷期:2009年28-20]
- Base excision repair (BER) is the major cellular pathway involved in removal of endogenous/spontaneous DNA lesions. Here, we study the mechanism that controls the steady-state levels of BER enzymes in human cells. By fra...
- Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
[作者:Andersen, JL; Johnson, CE; Freel, CD; Parrish, AB; Day, JL; Buchakjian, MR; Nutt, LK; Thompson, JW; Moseley, MA; Kornbluth, S,期刊:EMBO journal, 页码:3216-3227 , 文章类型: Article,,卷期:2009年28-20]
- The apoptotic initiator caspase-2 has been implicated in oocyte death, in DNA damage-and heat shock-induced death, and in mitotic catastrophe. We show here that the mitosis-promoting kinase, cdk1-cyclin B1, suppresses ap...
- Zfh1 promotes survival of a peripheral glia subtype by antagonizing a Jun N-terminal kinase-dependent apoptotic pathway
[作者:Ohayon, D; Pattyn, A; Venteo, S; Valmier, J; Carroll, P; Garces, A,期刊:EMBO journal, 页码:3228-3243 , 文章类型: Article,,卷期:2009年28-20]
- In Drosophila subperineurial glia (SPG) ensheath and insulate the nerve. SPG is under strict cell cycle and survival control because cell division or death of such a cell type would compromise the integrity of the blood-...
- Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation
[作者:Ko, J; Zhang, C; Arac, D; Boucard, AA; Brunger, AT; Sudhof, TC,期刊:EMBO journal, 页码:3244-3255 , 文章类型: Article,,卷期:2009年28-20]
- Postsynaptic neuroligins are thought to perform essential functions in synapse validation and synaptic transmission by binding to, and dimerizing, presynaptic alpha- and beta-neurexins. To test this hypothesis, we examin...
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