- Oncogene and tumour suppressor: the two faces of SnoN
[作者：Lamouille, S; Derynck, R,期刊：EMBO journal, 页码：3459-3460 , 文章类型： Editorial Material，,卷期：2009年28-22]
- SnoN was first identified based on its homology with the proto-oncogene c-Ski, and has since been implicated as a promoter of oncogenic transformation and cancer progression. Consistent with a role as proto-oncogene, Sno...
- Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
[作者：Liu, NS; Loo, LS; Loh, E; Seet, LF; Hong, WJ,期刊：EMBO journal, 页码：3485-3499 , 文章类型： Article，,卷期：2009年28-22]
- Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. W...
- RNase Y, a novel endoribonuclease, initiates riboswitch turnover in Bacillus subtilis
[作者：Shahbabian, K; Jamalli, A; Zig, L; Putzer, H,期刊：EMBO journal, 页码：3523-3533 , 文章类型： Article，,卷期：2009年28-22]
- In contrast to Escherichia coli, initiation of mRNA decay in Gram-positive organisms is poorly understood. We studied the fate of the highly structured RNAs generated by premature transcription termination of S-adenosylm...
- PARP-1 transcriptional activity is regulated by sumoylation upon heat shock
[作者：Martin, N; Schwamborn, K; Schreiber, V; Werner, A; Guillier, C; Zhang, XD; Bischof, O; Seeler, JS; Dejean, A,期刊：EMBO journal, 页码：3534-3548 , 文章类型： Article，,卷期：2009年28-22]
- Heat shock and other environmental stresses rapidly induce transcriptional responses subject to regulation by a variety of post-translational modifications. Among these, poly(ADP-ribosyl)ation and sumoylation have receiv...
- The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans
[作者：Meier, B; Barber, LJ; Liu, Y; Shtessel, L; Boulton, SJ; Gartner, A; Ahmed, S,期刊：EMBO journal, 页码：3549-3563 , 文章类型： Article，,卷期：2009年28-22]
- The telomerase reverse transcriptase adds de novo DNA repeats to chromosome termini. Here we define Caenorhabditis elegans MRT-1 as a novel factor required for telomerase-mediated telomere replication and the DNA-damage ...
- Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn
[作者：Lim, SH; Kwon, SK; Lee, MK; Moon, J; Jeong, DG; Park, E; Kim, SJ; Park, BC; Lee, SC; Ryu, SE; Yu, DY; Chung, BH; Kim, E; Myung, PK; Lee, JR,期刊：EMBO journal, 页码：3564-3578 , 文章类型： Article，,卷期：2009年28-22]
- The receptor-type protein tyrosine phosphatases (RPTPs) have been linked to signal transduction, cell adhesion, and neurite extension. PTPRT/RPTPq is exclusively expressed in the central nervous system and regulates syna...
- Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands
[作者：Florence, WC; Xia, CF; Gordy, LE; Chen, WL; Zhang, YL; Scott-Browne, J; Kinjo, Y; Yu, KOA; Keshipeddy, S; Pellicci, DG; Patel, O; Kjer-Nielsen, L; McCluskey, J; Godfrey, DI; Rossjohn, J; Richardson, SK; Porcelli, SA; Howell, AR; Hayakawa, K; Gapin, L; Zajonc, DM; Wang, PG; Joyce, S,期刊：EMBO journal, 页码：3579-3590 , 文章类型： Article，,卷期：2009年28-22]
- The semi-invariant natural killer (NK) T-cell receptor (NKTcr) recognises structurally diverse glycolipid antigens presented by the monomorphic CD1d molecule. While the alpha-chain of the NKTcr is invariant, the beta-cha...
- AP-2 gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene
[作者：Williams, CMJ; Scibetta, AG; Friedrich, JK; Canosa, M; Berlato, C; Moss, CH; Hurst, HC,期刊：EMBO journal, 页码：3591-3601 , 文章类型： Article，,卷期：2009年28-22]
- Overexpression of the activator protein (AP)-2 gamma transcription factor in breast tumours has been identified as an independent predictor of poor outcome and failure of hormone therapy. To understand further the functi...
- Mg2+-dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis
[作者：Hattori, M; Iwase, N; Furuya, N; Tanaka, Y; Tsukazaki, T; Ishitani, R; Maguire, ME; Ito, K; Maturana, A; Nureki, O,期刊：EMBO journal, 页码：3602-3612 , 文章类型： Article，,卷期：2009年28-22]
- The MgtE family of Mg2+ transporters is ubiquitously distributed in all phylogenetic domains. Recent crystal structures of the full-length MgtE and of its cytosolic domain in the presence and absence of Mg2+ suggested a ...
- Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
[作者：Barren, B; Gakhar, L; Muradov, H; Boyd, KK; Ramaswamy, S; Artemyev, NO,期刊：EMBO journal, 页码：3613-3622 , 文章类型： Article，,卷期：2009年28-22]
- The inhibitory interaction of phosphodiesterase-6 (PDE6) with its gamma-subunit (P gamma) is pivotal in vertebrate phototransduction. Here, crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexe...
- The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
[作者：Anthis, NJ; Wegener, KL; Ye, F; Kim, C; Goult, BT; Lowe, ED; Vakonakis, I; Bate, N; Critchley, DR; Ginsberg, MH; Campbell, ID,期刊：EMBO journal, 页码：3623-3632 , 文章类型： Article，,卷期：2009年28-22]
Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from with...
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