- Fussy mitochondria fuse in response to stress
[作者:van der Bliek, AM,期刊:EMBO journal, 页码:1533-1534 , 文章类型: Article,,卷期:2009年28-11]
- When cells become committed to apoptosis, they shatter their mitochondrial networks through the actions of the mitochondrial fission protein DRP1. Massive fragmentation of mitochondria facilitates simultaneous release of...
- One way for the gastric proton pump
[作者:Nissen, P,期刊:EMBO journal, 页码:1535-1536 , 文章类型: Article,,卷期:2009年28-11]
- We are occasionally reminded of the gastric proton pump (H+, K+-ATPase) acidifying the gastric juice as an unpleasant symptom of heartburn. A paper by Abe et al in this issue of the EMBO Journal (Abe et al (2009)) provid...
- Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity
[作者:Schwappacher, R; Weiske, J; Heining, E; Ezerski, V; Marom, B; Henis, YI; Huber, O; Knaus, P,期刊:EMBO journal, 页码:1537-1550 , 文章类型: Article,,卷期:2009年28-11]
- Integration of multiple signals into the canonical BMP/Smad pathway poses a big challenge during the course of embryogenesis and tissue homeostasis. Here, we show that cyclic guanosine 3',5'-monophosphate (cGMP)-dependen...
- Small RNA-induced differential degradation of the polycistronic mRNA iscRSUA
[作者:Desnoyers, G; Morissette, A; Prevost, K; Masse, E,期刊:EMBO journal, 页码:1551-1561 , 文章类型: Article,,卷期:2009年28-11]
- Most polycistronic genes are expressed in a single transcript, in which each cistron produces a fixed amount of protein. In this report, we show the first example of differential degradation of a polycistronic gene induc...
- Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression
[作者:Varela, E; Shimada, K; Laroche, T; Leroy, D; Gasser, SM,期刊:EMBO journal, 页码:1562-1575 , 文章类型: Article,,卷期:2009年28-11]
- The mechanism of chromatin compaction in mitosis has been well studied, while little is known about what controls chromatin decompaction in early G1 phase. We have localized the Condensin subunit Brn1 to a compact spiral...
- The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation
[作者:Rigou, P; Piddubnyak, V; Faye, A; Rain, JC; Michel, L; Calvo, F; Poyet, JL,期刊:EMBO journal, 页码:1576-1588 , 文章类型: Article,,卷期:2009年28-11]
- The nuclear factor Acinus has been suggested to mediate apoptotic chromatin condensation after caspase cleavage. However, this role has been challenged by recent observations suggesting a contribution of Acinus in apopto...
- SLP-2 is required for stress-induced mitochondrial hyperfusion
[作者:Tondera, D; Grandemange, S; Jourdain, A; Karbowski, M; Mattenberger, Y; Herzig, S; Da Cruz, S; Clerc, P; Raschke, I; Merkwirth, C; Ehses, S; Krause, F; Chan, DC; Alexander, C; Bauer, C; Youle, R; Langer, T; Martinou, JC,期刊:EMBO journal, 页码:1589-1600 , 文章类型: Article,,卷期:2009年28-11]
- Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial fusion relies on dynamin-related GTPases, the mitofusins (MFN1 an...
- Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning
[作者:Cai, SQ; Wang, Y; Park, KH; Tong, X; Pan, Z; Sesti, F,期刊:EMBO journal, 页码:1601-1611 , 文章类型: Article,,卷期:2009年28-11]
- Here, we characterize a new K+ channel-kinase complex that operates in the metazoan Caenorhabditis elegans to control learning behaviour. This channel is composed of a pore-forming subunit, dubbed KHT-1 (73% homology to ...
- XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
[作者:Hu, CCA; Dougan, SK; McGehee, AM; Love, JC; Ploegh, HL,期刊:EMBO journal, 页码:1624-1636 , 文章类型: Article,,卷期:2009年28-11]
XBP-1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity to secrete IgM has been...
- Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle
[作者:Abe, K; Tani, K; Nishizawa, T; Fujiyoshi, Y,期刊:EMBO journal, 页码:1637-1643 , 文章类型: Article,,卷期:2009年28-11]
- The gastric H+,K+-ATPase is an ATP-driven proton pump responsible for generating a million-fold proton gradient across the gastric membrane. We present the structure of gastric H+,K+-ATPase at 6.5 angstrom resolution as ...
- Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains
[作者:Boer, DR; Ruiz-Maso, JA; Lopez-Blanco, JR; Blanco, AG; Vives-Llacer, M; Chacon, P; Uson, I; Gomis-Ruth, FX; Espinosa, M; Llorca, O; del Solar, G; Coll, M,期刊:EMBO journal, 页码:1666-1678 , 文章类型: Article,,卷期:2009年28-11]
- RepB initiates plasmid rolling-circle replication by binding to a triple 11-bp direct repeat (bind locus) and cleaving the DNA at a specific distant site located in a hairpin loop within the nic locus of the origin. The ...
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