- Transcription factor C/EBP beta isoform ratio regulates osteoclastogenesis through MafB
[作者：Smink, JJ; Begay, V; Schoenmaker, T; Sterneck, E; de Vries, TJ; Leutz, A,期刊：EMBO journal, 页码：1769-1781 , 文章类型： Article，,卷期：2009年28-12]
- Disequilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts is central to many bone diseases. Here, we show that dysregulated expression of translationally controlled isoforms of CCAAT/enhancer-binding...
- Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA
[作者：Dunham, TD; Xu, WJ; Funnell, BE; Schumacher, MA,期刊：EMBO journal, 页码：1792-1802 , 文章类型： Article，,卷期：2009年28-12]
- The accurate segregation of DNA is essential for the faithful inheritance of genetic information. Segregation of the prototypical P1 plasmid par system requires two proteins, ParA and ParB, and a centromere. When bound t...
- Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase
[作者：Sugiyama, K; Obayashi, E; Kawaguchi, A; Suzuki, Y; Tame, JRH; Nagata, K; Park, SY,期刊：EMBO journal, 页码：1803-1811 , 文章类型： Article，,卷期：2009年28-12]
- Influenza virus RNA-dependent RNA polymerase is a multi-functional heterotrimer, which uses a 'cap-snatching' mechanism to produce viral mRNA. Host cell mRNA is cleaved to yield a cap-bearing oligonucleotide, which can b...
- Crystal structure and association behaviour of the GluR2 amino-terminal domain
[作者：Jin, RS; Singh, SK; Gu, SY; Furukawa, H; Sobolevsky, AI; Zhou, J; Jin, Y; Gouaux, E,期刊：EMBO journal, 页码：1812-1823 , 文章类型： Article，,卷期：2009年28-12]
Fast excitatory neurotransmission is mediated largely by ionotropic glutamate receptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three subfamilies, AMPA, kainate and NMDA receptors, with ea...
- ncRNA transcription makes its mark
[作者：Hartzog, GA; Martens, JA,期刊：EMBO journal, 页码：1679-1680 , 文章类型： Article，,卷期：2009年28-12]
- A recently recognized strategy for gene regulation involves transcription of a non-coding RNA (ncRNA) transcript that overlaps the gene targeted for regulation. In many cases, it seems that it is the act of transcription...
- Super DksAs: substitutions in DksA enhancing its effects on transcription initiation
[作者：Blankschien, MD; Lee, JH; Grace, ED; Lennon, CW; Halliday, JA; Ross, W; Gourse, RL; Herman, C,期刊：EMBO journal, 页码：1720-1731 , 文章类型： Article，,卷期：2009年28-12]
- At specific times during bacterial growth, the transcription factor DksA and the unusual nucleotide regulator ppGpp work synergistically to inhibit some Escherichia coli promoters (e.g. rRNA promoters) and to stimulate o...
- Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli
[作者：Ninnis, RL; Spall, SK; Talbo, GH; Truscott, KN; Dougan, DA,期刊：EMBO journal, 页码：1732-1744 , 文章类型： Article，,卷期：2009年28-12]
- The N-end rule pathway is conserved from bacteria to man and determines the half-life of a protein based on its N-terminal amino acid. In Escherichia coli, model substrates bearing an N-degron are recognised by ClpS and ...
- Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination
[作者：Ma, CH; Rowley, PA; Macieszak, A; Guga, P; Jayaram, M,期刊：EMBO journal, 页码：1745-1756 , 文章类型： Article，,卷期：2009年28-12]
- Water, acting as a rogue nucleophile, can disrupt transesterification steps of important phosphoryl transfer reactions in DNA and RNA. We have unveiled this risk, and identified safeguards instituted against it, during s...
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