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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Measuring ubiquitin chain linkage: Rap80 uses a molecular ruler mechanism for ubiquitin linkage specificity [作者：Walters, KJ; Chen, X,期刊：EMBO journal, 页码：2307-2308 , 文章类型： Article，,卷期：2009年28-16] DNA double-stranded breaks lead to the recruitment of the Rnf8-Ubc13 complex to the damage site where they catalyse K63-linked ubiquitination. Receptor-associated protein 80 (Rap80) subsequently binds the K63-linked chai... Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase [作者：Shore, D; Bianchi, A,期刊：EMBO journal, 页码：2309-2322 , 文章类型： Review，,卷期：2009年28-16] The conventional DNA polymerase machinery is unable to fully replicate the ends of linear chromosomes. To surmount this problem, nearly all eukaryotes use the telomerase enzyme, a specialized reverse transcriptase that u... A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs [作者：Schoeftner, S; Blasco, MA,期刊：EMBO journal, 页码：2323-2336 , 文章类型： Review，,卷期：2009年28-16] Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeri... Focus on the centre: the role of chromatin on the regulation of centromere identity and function [作者：Torras-Llort, M; Moreno-Moreno, O; Azorin, F,期刊：EMBO journal, 页码：2337-2348 , 文章类型： Review，,卷期：2009年28-16] The centromere is a specialised chromosomal structure that regulates faithful chromosome segregation during cell division, as it dictates the site of assembly of the kinetochore, a critical structure that mediates bindin... A conserved haem redox and trafficking pathway for cofactor attachment [作者：Richard-Fogal, CL; Frawley, ER; Bonner, ER; Zhu, HF; Francisco, BS; Kranz, RG,期刊：EMBO journal, 页码：2349-2359 , 文章类型： Article，,卷期：2009年28-16] A pathway for cytochrome c maturation (Ccm) in bacteria, archaea and eukaryotes (mitochondria) requires the genes encoding eight membrane proteins (CcmABCDEFGH). The CcmABCDE proteins are proposed to traffic haem to the ... Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling [作者：Wang, ZZ; Sandiford, S; Wu, CG; Li, SSC,期刊：EMBO journal, 页码：2360-2373 , 文章类型： Article，,卷期：2009年28-16] Epithelial-mesenchymal transition (EMT), which can be caused by aberrant tyrosine kinase signalling, marks epithelial tumour progression and metastasis, yet the underlying molecular mechanism is not fully understood. Her... Intrakinetochore localization and essential functional domains of Drosophila Spc105 [作者：Schittenhelm, RB; Chaleckis, R; Lehner, CF,期刊：EMBO journal, 页码：2374-2386 , 文章类型： Article，,卷期：2009年28-16] The kinetochore is assembled during mitotic and meiotic divisions within the centromeric region of chromosomes. It is composed of more than eighty different proteins. Spc105 (also designated as Spc7, KNL-1 or Blinkin in ... Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein [作者：Camenisch, U; Trautlein, D; Clement, FC; Fei, J; Leitenstorfer, A; Ferrando-May, E; Naegeli, H,期刊：EMBO journal, 页码：2387-2399 , 文章类型： Article，,卷期：2009年28-16] Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix-distorting base lesions. To understand how this versatile subunit searches for aberrant sites within the vast background of normal ge... MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair [作者：Roques, C; Coulombe, Y; Delannoy, M; Vignard, J; Grossi, S; Brodeur, I; Rodrigue, A; Gautier, J; Stasiak, AZ; Stasiak, A; Constantinou, A; Masson, JY,期刊：EMBO journal, 页码：2400-2413 , 文章类型： Article，,卷期：2009年28-16] Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. It was reported earlier that FANCD2 co-localizes with NBS1. However, the functional connection between... Novel roles for A-type lamins in telomere biology and the DNA damage response pathway [作者：Gonzalez-Suarez, I; Redwood, AB; Perkins, SM; Vermolen, B; Lichtensztejin, D; Grotsky, DA; Morgado-Palacin, L; Gapud, EJ; Sleckman, BP; Sullivan, T; Sage, J; Stewart, CL; Mai, S; Gonzalo, S,期刊：EMBO journal, 页码：2414-2427 , 文章类型： Article，,卷期：2009年28-16] A-type lamins are intermediate filament proteins that provide a scaffold for protein complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked to a variety of degenerative disorders terme... Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF [作者：Ottaviani, A; Schluth-Bolard, C; Rival-Gervier, S; Boussouar, A; Rondier, D; Foerster, AM; Morere, J; Bauwens, S; Gazzo, S; Callet-Bauchu, E; Gilson, E; Magdinier, F,期刊：EMBO journal, 页码：2428-2436 , 文章类型： Article，,卷期：2009年28-16] The localization of genes within the nuclear space is of paramount importance for proper genome functions. However, very little is known on the cis-acting elements determining subnuclear positioning of chromosome segment... Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans [作者：Suo, S; Culotti, JG; Van Tol, HHM,期刊：EMBO journal, 页码：2437-2448 , 文章类型： Article，,卷期：2009年28-16] Animals assess food availability in their environment by sensory perception and respond to the absence of food by changing hormone and neurotransmitter signals. However, it is largely unknown how the absence of food is p... The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice [作者：Marchetti, S; Gamas, P; Belhacene, N; Grosso, S; Pradelli, LA; Colosetti, P; Johansen, C; Iversen, L; Deckert, M; Luciano, F; Hofman, P; Ortonne, N; Khemis, A; Mari, B; Ortonne, JP; Ricci, JE; Auberger, P,期刊：EMBO journal, 页码：2449-2460 , 文章类型： Article，,卷期：2009年28-16] We showed previously that Lyn is a substrate for caspases, a family of cysteine proteases, involved in the regulation of apoptosis and inflammation. Here, we report that expression of the caspase-cleaved form of Lyn (Lyn... Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80 [作者：Sato, Y; Yoshikawa, A; Mimura, H; Yamashita, M; Yamagata, A; Fukai, S,期刊：EMBO journal, 页码：2461-2468 , 文章类型： Article，,卷期：2009年28-16] RAP80 has a key role in the recruitment of the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interac... Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex [作者：Janssen, BJC; Gomes, L; Koning, RI; Svergun, DI; Koster, AJ; Fritzinger, DC; Vogel, CW; Gros, P,期刊：EMBO journal, 页码：2469-2478 , 文章类型： Article，,卷期：2009年28-16] Immune protection by the complement system critically depends on assembly of C3 convertases on the surface of pathogens and altered host cells. These short-lived protease complexes are formed through pro-convertases, whi... Structure and function of a novel endonuclease acting on branched DNA substrates [作者：Ren, B; Kuhn, J; Meslet-Cladiere, L; Briffotaux, J; Norais, C; Lavigne, R; Flament, D; Ladenstein, R; Myllykallio, H,期刊：EMBO journal, 页码：2479-2489 , 文章类型： Article，,卷期：2009年28-16] We show that Pyrococcus abyssi PAB2263 (dubbed NucS (nuclease for ss DNA) is a novel archaeal endonuclease that interacts with the replication clamp PCNA. Structural determination of P. abyssi NucS revealed a two-domain ...