- Altered uric acid levels and disease states
[作者:Kutzing, MK; Firestein, BL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1-7 , 文章类型: Article,,卷期:2008年324-1]
Altered serum uric acid concentrations, both above and below normal levels, have been linked to a number of disease states. An abnormally high uric acid level has been correlated with gout, hypertension, cardiovascula...
- Calcium-activated potassium channels in insect pacemaker neurons as unexpected target site for the novel fumigant dimethyl disulfide
[作者:Gautier, H; Auger, J; Legros, C; Lapied, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:149-159 , 文章类型: Article,,卷期:2008年324-1]
Dimethyl disulfide (DMDS), a plant-derived insecticide, is a promising fumigant as a substitute for methyl bromide. To further understand the mode of action of DMDS, we examined its effect on cockroach octopaminergic ...
- The A(3) adenosine receptor agonist CP-532,903 [N-6-( 2,5-dichlorobenzyl)-3 '-aminoadenosine-5 '-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel
[作者:Wan, TC; Ge, ZD; Tampo, A; Mio, Y; Bienengraeber, MW; Tracey, WR; Gross, GJ; Kwok, WM; Auchampach, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:234-243 , 文章类型: Article,,卷期:2008年324-1]
We examined the cardioprotective profile of the new A(3) adenosine receptor (AR) agonist CP-532,903 [N-6-(2,5-dichlorobenzyl)-3 '-aminoadenosine-5 '-N-methylcarboxamide] in an in vivo mouse model of infarction and an ...
- Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells
[作者:Shen, F; Chu, S; Bence, AK; Bailey, B; Xue, X; Erickson, PA; Montrose, MH; Beck, WT; Erickson, LC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:95-102 , 文章类型: Article,,卷期:2008年324-1]
P-glycoprotein (Pgp), a membrane transporter encoded by the MDR1 gene in human cells, mediates drug efflux from cells, and it plays a major role in causing multidrug resistance (MDR). Confocal microscopy was used to s...
- Tachykinin NK2 receptor and functional mechanisms in human colon: Changes with indomethacin and in diverticular disease and ulcerative colitis
[作者:Burcher, E; Shang, F; Warner, FJ; Du, Q; Lubowski, DZ; King, DW; Liu, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:170-178 , 文章类型: Article,,卷期:2008年324-1]
Neurokinin A (NKA) is an important spasmogen in human colon. We examined inflammatory disease-related changes in the tachykinin NK2 receptor system in human sigmoid colon circular muscle, using functional, radioligand...
- Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages
[作者:Du, T; Filiz, G; Caragounis, A; Crouch, PJ; White, AR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:360-367 , 文章类型: Article,,卷期:2008年324-1]
Copper has an important role in cancer growth, angiogenesis, and metastasis. Previous studies have shown that cell-permeable metal ligands, including clioquinol (CQ) and pyrrolidine dithiocarbamate, inhibit cancer cel...
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