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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共45条记录   Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification [作者：Schopf, E; Fischer, NO; Chen, Y; Tok, JBH,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5871-5874 , 文章类型： Article，,卷期：2008年18-22] We report a sensitive and efficient magnetic bead-based assay for viral DNA identification using isothermal amplification of a reporting probe. (C) 2008 Elsevier Ltd. All rights reserved. Synthesis and characterization of BODIPY-labeled colchicine [作者：Arnold, LA; Ranaivo, P; Guy, RK,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5867-5870 , 文章类型： Article，,卷期：2008年18-22] Two BODIPY-labeled colchicine derivatives were synthesized and shown to bind to tubulin but only partially inhibit tubulin polymerization in the presence of GTP. Cytotoxicity studies were carried out in HeLa, HepG2, Raji... Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels [作者：Nomura, DK; Hudak, CSS; Ward, AM; Burston, JJ; Issa, RS; Fisher, KJ; Abood, ME; Wiley, JL; Lichtman, AH; Casida, JE,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5875-5878 , 文章类型： Article，,卷期：2008年18-22] The structure-activity relationships of organophosphorus (OP) and organosulfur compounds were examined in vitro and in vivo as inhibitors of mouse brain monoacylglycerol lipase (MAGL) hydrolysis of 2-arachidonoylglycerol... Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide [作者：Lebreton, S; Jaunbergs, J; Roth, MG; Ferguson, DA; De Brabander, JK,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5879-5883 , 文章类型： Article，,卷期：2008年18-22] The natural product salicylihalamide is a potent inhibitor of the Vacuolar ATPase (V-ATPase), a potential target for antitumor chemotherapy. We generated salicylihalamide- resistant tumor cell lines typified by an overex... Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells [作者：Palchaudhuri, R; Hergenrother, PJ,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5888-5891 , 文章类型： Article，,卷期：2008年18-22] Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of... Conformational analysis of a covalently cross-linked Watson-Crick base pair model [作者：Jensen, EA; Allen, BD; Kishi, Y; O'Leary, DJ,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5884-5887 , 文章类型： Article，,卷期：2008年18-22] Low-temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Cri... The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues [作者：Udugamasooriya, DG; Dunham, G; Ritchie, C; Brekken, RA; Kodadek, T,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5892-5894 , 文章类型： Article，,卷期：2008年18-22] Here we identify the pharmacophore in a peptoid that antagonizes Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) in vitro and in vivo. Only three of the side chains in the peptoid are required for activity. Surpri... Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design [作者：Tully, DC; Vidal, A; Chatterjee, AK; Williams, JA; Roberts, MJ; Petrassi, HM; Spraggon, G; Bursulaya, B; Pacoma, R; Shipway, A; Schumacher, AM; Danahay, H; Harris, JL,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5895-5899 , 文章类型： Article，,卷期：2008年18-22] Structure-based design was utilized to guide the early stage optimization of a substrate-like inhibitor to afford potent peptidomimetic inhibitors of the channel-activating protease prostasin. The first X-ray crystal str... Immucillins in custom catalytic-site cavities [作者：Murkin, AS; Clinch, K; Mason, JM; Tyler, PC; Schramm, VL,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5900-5903 , 文章类型： Article，,卷期：2008年18-22] Neighboring-group participation in the reaction catalyzed by purine nucleoside phosphorylase involves a compression mode between the 5'- and 4'-ribosyl oxygens, facilitated by His257. The His257Gly mutant opens a space i... Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics [作者：Schneekloth, AR; Pucheault, M; Tae, HS; Crews, CM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5904-5908 , 文章类型： Article，,卷期：2008年18-22] We have developed a heterobifunctional all-small molecule PROTAC (PROteolysis TArgeting Chimera) capable of inducing proteasomal degradation of the androgen receptor. This cell permeable PROTAC consists of a non-steroida... Synthesis of alpha-helix mimetics with four side-chains [作者：Restorp, P; Rebek, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5909-5911 , 文章类型： Article，,卷期：2008年18-22] The synthesis of a heterocyclic piperazine-based scaffold that mimics the i, i + 4, i + 8, i + 11 side-chain projections of an alpha-helix is described. The synthesis is designed to be modular to allow the targeting of a... Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase [作者：Hur, W; Velentza, A; Kim, S; Flatauer, L; Jiang, XN; Valente, D; Mason, DE; Suzuki, M; Larson, B; Zhang, JM; Zagorska, A; DiDonato, M; Nagle, A; Warmuth, M; Balk, SP; Peters, EC; Gray, NS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5916-5919 , 文章类型： Article，,卷期：2008年18-22] Irreversible HER/erbB inhibitors selectively inhibit HER-family kinases by targeting a unique cysteine residue located within the ATP-binding pocket. Sequence alignment reveals that this rare cysteine is also present in ... Development of novel tail-modified anandamide analogs [作者：Yao, FM; Li, C; Vadivel, SK; Bowman, AL; Makriyannis, A,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5912-5915 , 文章类型： Article，,卷期：2008年18-22] To explore the hydrophobic groove subsite within the CB1 cannabinoid receptor we have designed and synthesized a group of tail-substituted anandamide analogs. Our design involves the introduction of aryl or heterocyclic ... Trace amine-associated receptor 1 (TAAR(1)) is activated by amiodarone metabolites [作者：Snead, AN; Miyakawa, M; Tan, ES; Scanlan, TS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5920-5922 , 文章类型： Article，,卷期：2008年18-22] Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodaron... Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking [作者：Hassan, AQ; Stubbe, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5923-5925 , 文章类型： Article，,卷期：2008年18-22] Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside 5'-diphosphates to deoxynucleoside 5'-diphosphates and is a 1: 1 complex of two homodimeric subunits: alpha 2 and beta 2. As a first ... Development of bestatin-based activity-based probes for metallo-aminopeptidases [作者：Harbut, MB; Velmourougane, G; Reiss, G; Chandramohanadas, R; Greenbaum, DC,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5932-5936 , 文章类型： Article，,卷期：2008年18-22] A novel set of activity-based probes (ABPs) for functionally pro. ling metallo-aminopeptidases was synthesized based on the bestatin inhibitor scaffold, the first synthesis of bestatin analogues using solid-phase techniq...