- An efficient chemical approach to bispecific antibodies and antibodies of high valency
[作者:Gavrilyuk, JI; Wuellner, U; Salahuddin, S; Goswami, RK; Sinha, SC; Barbas, CF,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3716-3720 , 文章类型: Article,,卷期:2009年19-14]
- Irreversible chemical programming of monoclonal aldolase antibody (mAb) 38C2 has been accomplished with beta-lactam equipped mono-and bifunctional targeting modules, including a cyclic-RGD peptide linked to either the pe...
- Potential scorpionate antibiotics: Targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions
[作者:Albada, HB; Arnusch, CJ; Branderhorst, HM; Verel, AM; Janssen, WTM; Breukink, E; de Kruijff, B; Pieters, RJ; Liskamp, RMJ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3721-3724 , 文章类型: Article,,卷期:2009年19-14]
- The antibiotic vancomycin-that binds lipid II in the bacterial cell membrane-was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate w...
- Dynamic kinetic asymmetric transfer hydrogenation of racemic 2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines catalyzed by chiral phosphoric acids
[作者:Han, ZY; Xiao, H; Gong, LZ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3729-3732 , 文章类型: Article,,卷期:2009年19-14]
- Dynamic kinetic Transfer hydrogenation reaction of 2-methyl-2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines, using phosphoric acids as catalysts and Hantzsch ester as hydride source, has been studied. A 3,3'-H8-binol deriv...
- Identification of a beta(3)-peptide HIV fusion inhibitor with improved potency in live cells
[作者:Bautista, AD; Stephens, OM; Wang, LG; Domaoal, RA; Anderson, KS; Schepartz, A,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3736-3738 , 文章类型: Article,,卷期:2009年19-14]
- We recently reported a beta(3)-decapeptide, beta WWI-1, that binds a validated gp41 model in vitro and inhibits gp41-mediated fusion in cell culture. Here we report six analogs of beta WWI-1 containing a variety of non-n...
- Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA
[作者:Furman, JL; Badran, AH; Shen, SY; Stains, CI; Hannallah, J; Segal, DJ; Ghosh, I,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3748-3751 , 文章类型: Article,,卷期:2009年19-14]
- In order to directly detect nucleic acid polymers, we have designed biosensors comprising sequence-specific DNA binding proteins tethered to split-reporter proteins, which generate signal upon binding a predetermined nuc...
- Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking
[作者:Lawrence, HR; Li, ZY; Yip, MLR; Sung, SS; Lawrence, NJ; McLaughlin, ML; McManus, GJ; Zaworotko, MJ; Sebti, SM; Chen, JD; Guida, WC,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3756-3759 , 文章类型: Article,,卷期:2009年19-14]
- NSC 333003 has been identified from the NCI Diversity Set as an inhibitor of the MDM2-p53 protein-protein interaction by in silico docking (virtual screening). Its potency and chemical characteristics render it well suit...
- Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A
[作者:Pfeiffer, B; Hauenstein, K; Merz, P; Gertsch, J; Altmann, KH,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3760-3763 , 文章类型: Article,,卷期:2009年19-14]
- The SAR of a series of new epothilone A derivatives with a 2-substituted-1,3-oxazoline moiety trans-fused to the C12-C13 bond of the deoxy macrocycle have been investigated with regard to tubulin polymerization induction...
- Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs
[作者:Simon, G; Bouzon, M; Charmantray, F; Helaine, V; Legeret, B; Marliere, P; Hecquet, L,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3767-3770 , 文章类型: Article,,卷期:2009年19-14]
- Probes were developed for the in vivo detection of transketolase activity by the use of a complementation assay in Escherichia coli auxotrophs They combine the D-threo ketose moiety recognised by transketolase and the si...
- Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis
[作者:Whitby, LR; Lee, AM; Kunz, S; Oldstone, MBA; Boger, DL,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3771-3774 , 文章类型: Article,,卷期:2009年19-14]
- The comparative characterization of a series of 4-acyl-1,6-dialkylpiperazin-2-ones as potent cell entry inhibitors of the hemorrhagic fever arenavirus Lassa (LASV) is disclosed. The resolution and examination of the indi...
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