- Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm
[作者:Hashimoto, M; Morales, J; Fukai, Y; Suzuki, S; Takamiya, S; Tsubouchi, A; Inoue, S; Inoue, M; Kita, K; Harada, S; Tanaka, A; Aoki, T; Nara, T,期刊:Biochemical and Biophysical Research Communications, 页码:1002-1006 , 文章类型: Article,,卷期:2012年417-3]
- The intracellular parasitic protist Trypanosoma cruzi is the causative agent of Chagas disease in Latin America. In general, pyrimidine nucleotides are supplied by both de novo biosynthesis and salvage pathways. While ep...
- Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation
[作者:Kidani, Y; Ohshima, K; Sakai, H; Kohno, T; Baba, A; Hattori, M,期刊:Biochemical and Biophysical Research Communications, 页码:1014-1017 , 文章类型: Article,,卷期:2012年417-3]
- Sphingomyelin (SM) plays important roles in regulating structure and function of plasma membrane, but how intracellular localization of SM is regulated in neuronal cells is not understood. Here we show that two isoforms ...
- Regulation of enzyme activity of alcohol dehydrogenase through its interactions with pyruvate-ferredoxin oxidoreductase in Thermoanaerobacter tengcongensis
[作者:Wang, Q; Wang, QH; Tong, W; Bai, X; Chen, Z; Zhao, JJ; Zhang, JY; Liu, SQ,期刊:Biochemical and Biophysical Research Communications, 页码:1018-1023 , 文章类型: Article,,卷期:2012年417-3]
- Alcohol dehydrogenases (ADHs) from thermophilic microorganisms are interesting enzymes that have their potential applications in biotechnology and potentially provide insight into the mechanisms of action of thermo-toler...
- Anti-inflammatory effects of Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma
[作者:Lee, SH; Kim, DW; Kim, HR; Woo, SJ; Kim, SM; Jo, HS; Jeon, SG; Cho, SW; Park, JH; Won, MH; Park, J; Eum, WS; Choi, SY,期刊:Biochemical and Biophysical Research Communications, 页码:1024-1029 , 文章类型: Article,,卷期:2012年417-3]
- Chronic airway inflammation is a key feature of bronchial asthma. Annexin-1 (ANX1) is an anti-inflammatory protein that is an important modulator and plays a key role in inflammation. Although the precise action of ANX1 ...
- Reduction of nuclear encoded enzymes of mitochondrial energy metabolism in cells devoid of mitochondrial DNA
[作者:Mueller, EE; Mayr, JA; Zimmermann, FA; Feichtinger, RG; Stanger, O; Sperl, W; Kofler, B,期刊:Biochemical and Biophysical Research Communications, 页码:1052-1057 , 文章类型: Article,,卷期:2012年417-3]
- Mitochondrial DNA (mtDNA) depletion syndromes are generally associated with reduced activities of oxidative phosphorylation (OXPHOS) enzymes that contain subunits encoded by mtDNA. Conversely, entirely nuclear encoded mi...
- RAS oncogenic signal upregulates EZH2 in pancreatic cancer
[作者:Fujii, S; Fukamachi, K; Tsuda, H; Ito, K; Ito, Y; Ochiai, A,期刊:Biochemical and Biophysical Research Communications, 页码:1074-1079 , 文章类型: Article,,卷期:2012年417-3]
- The neoplastic transformation by mutant RAS is thought to require remodeling of expression of an entire set of genes. However, the underlying mechanism for initiation of gene expression remodeling in tumorigenesis remain...
- Software for precise tracking of cell proliferation
[作者:Kurokawa, H; Noda, H; Sugiyama, M; Sakaue-Sawano, A; Fukami, K; Miyawaki, A,期刊:Biochemical and Biophysical Research Communications, 页码:1080-1085 , 文章类型: Article,,卷期:2012年417-3]
- We have developed a multi-target cell tracking program TADOR, which we applied to a series of fluorescence images. TADOR is based on an active contour model that is modified in order to be free of the problem of locally ...
- miR-30 inhibits TGF-beta 1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1
[作者:Zhang, JC; Zhang, HY; Liu, JY; Tu, XL; Zang, YH; Zhu, J; Chen, JN; Dong, L; Zhang, JF,期刊:Biochemical and Biophysical Research Communications, 页码:1100-1105 , 文章类型: Article,,卷期:2012年417-3]
- Epithelial-to-mesenchymal transition (EMT) has been implicated in embryonic development and various pathological events. Snail1 is a well-known E-cadherin-transcriptional repressor that is significantly upregulated durin...
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