- Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
[作者:Dibble, CC; Asara, JM; Manning, BD,期刊:Molecular and Cellular Biology, 页码:5657-5670 , 文章类型: Article,,卷期:2009年29-21]
- The mammalian target of rapamycin (mTOR) functions within two distinct complexes (mTORC1 and mTORC2) to control cell growth, proliferation, survival, and metabolism. While there has been great progress in our understandi...
- Regulation of Protein Synthesis by Ionizing Radiation
[作者:Braunstein, S; Badura, ML; Xi, QR; Formenti, SC; Schneider, RJ,期刊:Molecular and Cellular Biology, 页码:5645-5656 , 文章类型: Article,,卷期:2009年29-21]
- Ionizing radiation (IR) is a physiologically important stress to which cells respond by the activation of multiple signaling pathways. Using a panel of immortalized and transformed breast epithelial cell lines, we demons...
- Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 To Facilitate the First Catalytic Reaction
[作者:Chiu, YF; Liu, YC; Chiang, TW; Yeh, TC; Tseng, CK; Wu, NY; Cheng, SC,期刊:Molecular and Cellular Biology, 页码:5671-5678 , 文章类型: Article,,卷期:2009年29-21]
- Cwc25 has previously been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (nineteen complex, or NTC) involved in spliceosome activation. We show here that Cwc...
- Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis, and a Block in c-Raf Activation
[作者:El-Naggar, S; Liu, YQ; Dean, DC,期刊:Molecular and Cellular Biology, 页码:5710-5717 , 文章类型: Article,,卷期:2009年29-21]
- Atk can be activated by two independent phosphorylation events. Growth factor-dependent phosphorylation of threonine 308 (Akt-308) by phosphatidylinositol 3-kinase-dependent PDK1 leads to activation of mammalian target o...
- Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress
[作者:Feng, JJ; Wakeman, T; Yong, SL; Wu, XH; Kornbluth, S; Wang, XF,期刊:Molecular and Cellular Biology, 页码:5696-5709 , 文章类型: Article,,卷期:2009年29-21]
- Eukaryotic genomic integrity is safeguarded by cell cycle checkpoints and DNA repair pathways, collectively known as the DNA damage response, wherein replication protein A (RPA) is a key regulator playing multiple critic...
- A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo
[作者:Minamishima, YA; Moslehi, J; Padera, RF; Bronson, RT; Liao, R; Kaelin, WG,期刊:Molecular and Cellular Biology, 页码:5729-5741 , 文章类型: Article,,卷期:2009年29-21]
- Hypoxia-inducible factor (HIF), consisting of a labile alpha subunit and a stable beta subunit, is a master regulator of hypoxia-responsive mRNAs. HIF alpha undergoes oxygen-dependent prolyl hydroxylation, which marks it...
- Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses
[作者:Cunnick, JM; Schmidhuber, S; Chen, G; Yu, M; Yi, SJ; Cho, YJ; Kaartinen, V; Minoo, P; Warburton, D; Groffen, J; Heisterkamp, N,期刊:Molecular and Cellular Biology, 页码:5742-5750 , 文章类型: Article,,卷期:2009年29-21]
- Bcr and Abr are GTPase-activating proteins for the small GTPase Rac. Both proteins are expressed in cells of the innate immune system, including neutrophils and macrophages. The function of Bcr has been linked to the neg...
- Mrd1p Is Required for Release of Base-Paired U3 snoRNA within the Preribosomal Complex
[作者:Lundkvist, P; Jupiter, S; Segerstolpe, A; Osheim, YN; Beyer, AL; Wieslander, L,期刊:Molecular and Cellular Biology, 页码:5763-5774 , 文章类型: Article,,卷期:2009年29-21]
- In eukaryotes, ribosomes are made from precursor rRNA (pre-rRNA) and ribosomal proteins in a maturation process that requires a large number of snoRNPs and processing factors. A fundamental problem is how the coordinated...
- HOXD13 Binds DNA Replication Origins To Promote Origin Licensing and Is Inhibited by Geminin
[作者:Salsi, V; Ferrari, S; Ferraresi, R; Cossarizza, A; Grande, A; Zappavigna, V,期刊:Molecular and Cellular Biology, 页码:5775-5788 , 文章类型: Article,,卷期:2009年29-21]
- HOX DNA-binding proteins control patterning during development by regulating processes such as cell aggregation and proliferation. Recently, a possible involvement of HOX proteins in replication origin activity was sugge...
- Human UPF1 Participates in Small RNA-Induced mRNA Downregulation
[作者:Jin, H; Suh, MR; Han, J; Yeom, KH; Lee, Y; Heo, I; Ha, M; Hyun, S; Kim, VN,期刊:Molecular and Cellular Biology, 页码:5789-5799 , 文章类型: Article,,卷期:2009年29-21]
- MicroRNAs (miRNAs) are endogenous antisense regulators that trigger endonucleolytic mRNA cleavage, translational repression, and/or mRNA decay. miRNA-mediated gene regulation is important for numerous biological pathways...
- Regulation of Myoblast Differentiation by the Nuclear Envelope Protein NET39
[作者:Liu, GH; Guan, T; Datta, K; Coppinger, J; Yates, J; Gerace, L,期刊:Molecular and Cellular Biology, 页码:5800-5812 , 文章类型: Article,,卷期:2009年29-21]
- Recently, several transmembrane proteins of the nuclear envelope have been implicated in regulation of signaling and gene expression. Here we demonstrate that the nuclear lamina-associated nuclear envelope transmembrane ...
- Blimp-1/Prdm1 Alternative Promoter Usage during Mouse Development and Plasma Cell Differentiation
[作者:Morgan, MAJ; Magnusdottir, E; Kuo, TC; Tunyaplin, C; Harper, J; Arnold, SJ; Calame, K; Robertson, EJ; Bikoff, EK,期刊:Molecular and Cellular Biology, 页码:5813-5827 , 文章类型: Article,,卷期:2009年29-21]
The zinc-finger PR domain transcriptional repressor Blimp-1/Prdm1 plays essential roles in primordial germ cell specification, placental, heart, and forelimb development, plasma cell differentiation, and T-cell homeos...
- Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis
[作者:Matsushita, T; Chan, YY; Kawanami, A; Balmes, G; Landreth, GE; Murakami, S,期刊:Molecular and Cellular Biology, 页码:5843-5857 , 文章类型: Article,,卷期:2009年29-21]
- Osteoblasts and chondrocytes arise from common osteo-chondroprogenitor cells. We show here that inactivation of ERK1 and ERK2 in osteo-chondroprogenitor cells causes a block in osteoblast differentiation and leads to ect...
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